Výsledky vyhledávání - "Erin G Schuetz"

Akademický článek

Vitamin D levels do not cause vitamin-drug interactions with dexamethasone or dasatinib in mice.

Autor: Kavya Annu, Kazuto Yasuda, William V Caufield, Burgess B Freeman, Erin G Schuetz

Publikováno v: PLoS ONE, Vol 16, Iss 10, p e0258579 (2021)

Vitamin D3 (VD3) induces intestinal CYP3A that metabolizes orally administered anti-leukemic chemotherapeutic substrates dexamethasone (DEX) and dasatinib potentially causing a vitamin-drug interaction. To determine the impact of VD3 status on system

Externí odkaz: https://doaj.org/article/2b256692a0f8435c85bc1753e5748a00

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Akademický článek

Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.

Autor: Samit Ganguly, David Finkelstein, Timothy I Shaw, Ryan D Michalek, Kimberly M Zorn, Sean Ekins, Kazuto Yasuda, Yu Fukuda, John D Schuetz, Kamalika Mukherjee, Erin G Schuetz

Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0253852 (2021)

Abcg2/Bcrp and Abcb1a/Pgp are xenobiotic efflux transporters limiting substrate permeability in the gastrointestinal system and brain, and increasing renal and hepatic drug clearance. The systemic impact of Bcrp and Pgp ablation on metabolic homeosta

Externí odkaz: https://doaj.org/article/b18f9e558107487fa2603259aa77bcbd

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Akademický článek

Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function

Autor: Alison E. Fohner, Rachel Dalton, Kasse Skagen, Konner Jackson, Katrina G. Claw, Scarlett E. Hopkins, Renee Robinson, Burhan A. Khan, Bhagwat Prasad, Erin G. Schuetz, Deborah A. Nickerson, Timothy A. Thornton, Denise A. Dillard, Bert B. Boyer, Kenneth E. Thummel, Erica L. Woodahl

Publikováno v: Clinical and Translational Science, Vol 14, Iss 4, Pp 1292-1302 (2021)

Abstract The frequencies of genetic variants in the CYP3A4 and CYP3A5 genes differ greatly across global populations, leading to profound differences in the metabolic activity of these enzymes and resulting drug metabolism rates, with important conse

Externí odkaz: https://doaj.org/article/18c815b78eaf46c482f67ddc2280dfe6

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Data from Ontogeny and Sorafenib Metabolism

Autor: Sharyn D. Baker, Hiroto Inaba, Jeffrey E. Rubnitz, Erin G. Schuetz, Amarjit S. Chaudhry, Alice Gibson, David Finkelstein, Lie Li, Justin L. Roberts, Eric I. Zimmerman

Purpose: To investigate the role of ontogeny in sorafenib metabolism to the equipotent active metabolite sorafenib N-oxide.Experimental Design: Steady-state pharmacokinetic studies of sorafenib and metabolites were conducted in 30 children and young

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0775a7349bf4b645daeaee5da04df2
https://doi.org/10.1158/1078-0432.c.6520551

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