Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Erin G Schuetz"'
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258579 (2021)
Vitamin D3 (VD3) induces intestinal CYP3A that metabolizes orally administered anti-leukemic chemotherapeutic substrates dexamethasone (DEX) and dasatinib potentially causing a vitamin-drug interaction. To determine the impact of VD3 status on system
Externí odkaz:
https://doaj.org/article/2b256692a0f8435c85bc1753e5748a00
Autor:
Samit Ganguly, David Finkelstein, Timothy I Shaw, Ryan D Michalek, Kimberly M Zorn, Sean Ekins, Kazuto Yasuda, Yu Fukuda, John D Schuetz, Kamalika Mukherjee, Erin G Schuetz
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253852 (2021)
Abcg2/Bcrp and Abcb1a/Pgp are xenobiotic efflux transporters limiting substrate permeability in the gastrointestinal system and brain, and increasing renal and hepatic drug clearance. The systemic impact of Bcrp and Pgp ablation on metabolic homeosta
Externí odkaz:
https://doaj.org/article/b18f9e558107487fa2603259aa77bcbd
Autor:
Sharyn D. Baker, Hiroto Inaba, Jeffrey E. Rubnitz, Erin G. Schuetz, Amarjit S. Chaudhry, Alice Gibson, David Finkelstein, Lie Li, Justin L. Roberts, Eric I. Zimmerman
Purpose: To investigate the role of ontogeny in sorafenib metabolism to the equipotent active metabolite sorafenib N-oxide.Experimental Design: Steady-state pharmacokinetic studies of sorafenib and metabolites were conducted in 30 children and young
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0775a7349bf4b645daeaee5da04df2
https://doi.org/10.1158/1078-0432.c.6520551
https://doi.org/10.1158/1078-0432.c.6520551
Autor:
Sharyn D. Baker, Hiroto Inaba, Jeffrey E. Rubnitz, Erin G. Schuetz, Amarjit S. Chaudhry, Alice Gibson, David Finkelstein, Lie Li, Justin L. Roberts, Eric I. Zimmerman
PDF file, 57K, Steady-state sorafenib metabolite ratios as a function of sex.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531994cf660aa1016578f1ea324beca5
https://doi.org/10.1158/1078-0432.22445760
https://doi.org/10.1158/1078-0432.22445760
Autor:
Sharyn D. Baker, Hiroto Inaba, Jeffrey E. Rubnitz, Erin G. Schuetz, Amarjit S. Chaudhry, Alice Gibson, David Finkelstein, Lie Li, Justin L. Roberts, Eric I. Zimmerman
PDF file, 104K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367d13eb3189e2bb050f7efa5a61771a
https://doi.org/10.1158/1078-0432.22445739.v1
https://doi.org/10.1158/1078-0432.22445739.v1
Autor:
Sharyn D. Baker, Hiroto Inaba, Jeffrey E. Rubnitz, Erin G. Schuetz, Amarjit S. Chaudhry, Alice Gibson, David Finkelstein, Lie Li, Justin L. Roberts, Eric I. Zimmerman
PDF file, 93K, Inhibition of CYP3A4-mediated sorafenib metabolism by azole compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fec18d1205dae67bc8e036ec52bd1b4
https://doi.org/10.1158/1078-0432.22445754.v1
https://doi.org/10.1158/1078-0432.22445754.v1
Autor:
Sharyn D. Baker, Hiroto Inaba, Jeffrey E. Rubnitz, Erin G. Schuetz, Amarjit S. Chaudhry, Alice Gibson, David Finkelstein, Lie Li, Justin L. Roberts, Eric I. Zimmerman
PDF file, 63K, Age- and sex-dependent sorafenib glucuronide formation and correlation with UGT1A9 mRNA expression in human liver samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a7cde2741e7c9ffb7789ca0458d5cc
https://doi.org/10.1158/1078-0432.22445748.v1
https://doi.org/10.1158/1078-0432.22445748.v1
Autor:
Sharyn D. Baker, Hiroto Inaba, Jeffrey E. Rubnitz, Erin G. Schuetz, Amarjit S. Chaudhry, Alice Gibson, David Finkelstein, Lie Li, Justin L. Roberts, Eric I. Zimmerman
PDF file, 76K, Identification of sorafenib glucuronide by high resolution mass spectrometry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf07a5dc1b5772b97f6edc4c6a8e722
https://doi.org/10.1158/1078-0432.22445745.v1
https://doi.org/10.1158/1078-0432.22445745.v1
Autor:
Sharyn D. Baker, Hiroto Inaba, Jeffrey E. Rubnitz, Erin G. Schuetz, Amarjit S. Chaudhry, Alice Gibson, David Finkelstein, Lie Li, Justin L. Roberts, Eric I. Zimmerman
PDF file, 53K, Patient demographics and steady-state pharmacokinetics of sorafenib and metabolites.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cb5c7059bf2e6c942e5885d68e9ecd
https://doi.org/10.1158/1078-0432.22445736.v1
https://doi.org/10.1158/1078-0432.22445736.v1
Autor:
Sharyn D. Baker, Hiroto Inaba, Jeffrey E. Rubnitz, Erin G. Schuetz, Amarjit S. Chaudhry, Alice Gibson, David Finkelstein, Lie Li, Justin L. Roberts, Eric I. Zimmerman
PDF file, 65K, Sorafenib metabolism by CYP and UGT enzymes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab13aaa3a25ba18ba55a9a2abf8940e
https://doi.org/10.1158/1078-0432.22445757.v1
https://doi.org/10.1158/1078-0432.22445757.v1