Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Erin Flaherty"'
Autor:
Lorna A. Farrelly, Shuangping Zheng, Nadine Schrode, Aaron Topol, Natarajan V. Bhanu, Ryan M. Bastle, Aarthi Ramakrishnan, Jennifer C Chan, Bulent Cetin, Erin Flaherty, Li Shen, Kelly Gleason, Carol A. Tamminga, Benjamin A. Garcia, Haitao Li, Kristen J. Brennand, Ian Maze
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Schizophrenia (SZ) is a severe psychiatric disorder; unfortunately, only ~1/3 of patients respond favorably to treatment. Here, the authors reveal hyperacetylation of histone H2A.Z in SZ neurons and postmortem SZ human brain tissues. They further sho
Externí odkaz:
https://doaj.org/article/82c68feb169f4133ac1edea10af43af7
Autor:
Gabriel E. Hoffman, Brigham J. Hartley, Erin Flaherty, Ian Ladran, Peter Gochman, Douglas M. Ruderfer, Eli A. Stahl, Judith Rapoport, Pamela Sklar, Kristen J. Brennand
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Induced pluripotent stem cell (hiPSC)-based models have inherent variations in their cellular and molecular output and readouts. Here, Hoffman and colleagues devise a method to account for gene expression variations in hiPSC-derived neurons from pati
Externí odkaz:
https://doaj.org/article/99c9b01d94b044f2bf2ad26960baaf9f
Autor:
Seok-Man Ho, Brigham J. Hartley, Erin Flaherty, Prashanth Rajarajan, Rawan Abdelaal, Ifeanyi Obiorah, Natalie Barretto, Hamza Muhammad, Hemali P. Phatnani, Schahram Akbarian, Kristen J. Brennand
Publikováno v:
Stem Cell Reports, Vol 9, Iss 2, Pp 615-628 (2017)
Summary: Modulation of transcription, either synthetic activation or repression, via dCas9-fusion proteins is a relatively new methodology with the potential to facilitate high-throughput up- or downregulation studies of gene function. Genetic studie
Externí odkaz:
https://doaj.org/article/2772a37d93fb404291498f59170646ce
Autor:
Derek Khorsand, MD, Jack Porrino, MD, Erin Flaherty, MD, Anshu Bandhlish, MD, Darin Davidson, MD
Publikováno v:
Radiology Case Reports, Vol 11, Iss 2, Pp 93-97 (2016)
We present a case of a solitary neurofibroma involving the right posterior shoulder of a 69-year-old man with degeneration into a massive, malignant peripheral nerve sheath tumor measuring more than 3 times the average reported size. The radiographic
Externí odkaz:
https://doaj.org/article/743db524971b4796bc396c513d4003d2
Publikováno v:
Journal of Plastic, Reconstructive & Aesthetic Surgery. 75:1497-1520
Autor:
Tom Maniatis, Erin Flaherty
Publikováno v:
Curr Opin Genet Dev
During development, individual neurons extend highly branched arbors that innervate the surrounding territory, enabling the formation of appropriate synaptic connections. The clustered protocadherins (cPCDH), a family of diverse cell-surface homophil
Publikováno v:
Schizophr Res
As expanding genetic and genomic studies continue to implicate a growing list of variants contributing risk to neuropsychiatric disease, an important next step is to understand the functional impact and points of convergence of these risk factors. He
Autor:
Esther Cheng, Erin Flaherty, Gabriel E. Hoffman, Marliette R. Matos, Amanda Dobbyn, Vineeta Singh, Deeptha Girish, Eli A. Stahl, Hirofumi Morishita, Laura M. Huckins, Seok-Man Ho, Emily Hoelzli, Sonya Abadali, Robert E. McCullumsmith, Pamela Sklar, Kazuhiko Yamamuro, Aaron Topol, Hemali Phatnani, Khaled Alganem, P J Michael Deans, Nadine Schrode, Bruce J. Aronow, James Gardner Gregory, Natalie Barretto, Kristen J. Brennand
Publikováno v:
Nature genetics
The mechanisms by which common risk variants of small effect interact to contribute to complex genetic disorders remain unclear. Here, we apply a genetic approach, using isogenic human induced pluripotent stem cells (hiPSCs), to evaluate the effects
Autor:
Lorraine N. Clark, Tom Maniatis, Harry Ostrer, Raiyan R. Khan, Nir Barzilai, Shai Carmi, Joseph Vijai, Laurie J. Ozelius, Max Lam, Danny Ben-Avraham, Susan B. Bressman, Anil K. Malhotra, Judy H. Cho, Ariel Darvasi, Erin Flaherty, Kenneth Offit, Steven M. Lipkin, Jin Yu, Robert J. Klein, Todd Lencz, Itsik Pe'er, Zeynep H. Gümüş, Gil Atzmon, Inga Peter
IMPORTANCE Schizophrenia is a serious mental illness with high heritability. While common genetic variants account for a portion of the heritability, identification of rare variants associated with the disorder has proven challenging. OBJECTIVE To id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23aefb1891776e69c84332fec4abb3ce
https://doi.org/10.1101/2020.05.29.20115352
https://doi.org/10.1101/2020.05.29.20115352
Autor:
Lorna A. Farrelly, Shuangping Zheng, Nadine Schrode, Aaron Topol, Natarajan V. Bhanu, Ryan M. Bastle, Aarthi Ramakrishnan, Jennifer C Chan, Bulent Cetin, Erin Flaherty, Li Shen, Kelly Gleason, Carol A. Tamminga, Benjamin A. Garcia, Haitao Li, Kristen J. Brennand, Ian Maze
Publikováno v:
Nature communications. 13(1)
Schizophrenia (SZ) is a psychiatric disorder with complex genetic risk dictated by interactions between hundreds of risk variants. Epigenetic factors, such as histone posttranslational modifications (PTMs), have been shown to play critical roles in m