Conversion of adult human fibroblasts into neural precursor cells using chemically modified mRNA

Autor: Bronwen Connor, Erin Firmin, Amy McCaughey-Chapman, Ruth Monk, Kevin Lee, Sophie Liot, Johannes Geiger, Carsten Rudolph, Kathryn Jones

Publikováno v: Heliyon, Vol 4, Iss 11, Pp e00918- (2018)

Direct reprogramming offers a unique approach by which to generate neural lineages for the study and treatment of neurological disorders. Our objective is to develop a clinically viable reprogramming strategy to generate neural precursor cells for th

Externí odkaz: https://doaj.org/article/a717b454f5db4da0bb215ebad3a89fc0

Non-Viral Generation of Neural Precursor-like Cells from Adult Human Fibroblasts

Autor: Mirella Dottori, Bronwen Connor, Charlotte Butler-Munro, Erin Firmin, Johanna M. Montgomery, Christof Maucksch

Publikováno v: Journal of Stem Cells & Regenerative Medicine
Scopus-Elsevier
Journal of Stem Cells and Regenerative Medicine, Vol 8, Iss 3, Pp 162-170 (2012)

Recent studies have reported direct reprogramming of human fibroblasts to mature neurons by the introduction of defined neural genes. This technology has potential use in the areas of neurological disease modeling and drug development. However, use o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6949941e855a51eabd057c8b7f7aa4
http://europepmc.org/articles/PMC3908292