Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Erin F. Boulanger"'
Autor:
Pankajavalli Thirugnanasambantham, Sravya Kovvali, Austin Cool, Yuan Gao, Anice Sabag-Daigle, Erin F. Boulanger, Mark Mitton-Fry, Angela Di Capua, Edward J. Behrman, Vicki H. Wysocki, Steffen Lindert, Brian M. M. Ahmer, Venkat Gopalan
Publikováno v:
Pathogens, Vol 11, Iss 10, p 1102 (2022)
Although salmonellosis, an infectious disease, is a significant global healthcare burden, there are no Salmonella-specific vaccines or therapeutics for humans. Motivated by our finding that FraB, a Salmonella deglycase responsible for fructose-aspara
Externí odkaz:
https://doaj.org/article/c280ab1c7e0c4598b514097154172a76
Identification of Small-Molecule Inhibitors of the Salmonella FraB Deglycase Using a Live-Cell Assay
Autor:
Anice Sabag-Daigle, Erin F. Boulanger, Pankajavalli Thirugnanasambantham, Jamison D. Law, Alex J. Bogard, Edward J. Behrman, Venkat Gopalan, Brian M. M. Ahmer
Publikováno v:
Microbiology Spectrum. 11
Nontyphoidal salmonellosis is a serious threat in the United States and globally. We have recently identified an enzyme, FraB, that when mutated renders Salmonella growth defective in vitro and unfit in mouse models of gastroenteritis.
Autor:
Brian M. M. Ahmer, Erin F Boulanger, Pankajavalli Thirugnanasambantham, Anice Sabag-Daigle, Venkat Gopalan
Publikováno v:
Microbiol Mol Biol Rev
Accumulation of phosphorylated intermediates during cellular metabolism can have wide-ranging toxic effects on many organisms, including humans and the pathogens that infect them. These toxicities can be induced by feeding an upstream metabolite (a s