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Abstract 2998: MLN4924 inhibition of Cullin-Ring ligases activates a hypoxic response and secretion of tumor promoting factors in human MCF7 breast cancer cells

Autor: James J. Rivard, Kevin J. Reagan, Erin Eleria, Greta Wegner, Neal Lee, Kathy Brumbaugh, Amy James

Publikováno v: Cancer Research. 75:2998-2998

Hypoxia-inducible factors (HIFs) are the key transcription factors that mediate the cellular response to low oxygen tension. During normoxia, HIF activity is tightly controlled by its oxygen-dependent prolyl hydroxylation which allows polyubiquitinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81f18f34b3538a315c6b40cb8bd2e80c
https://doi.org/10.1158/1538-7445.am2015-2998

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Abstract 3461: Profiling the effects of MEK inhibition on kinase phosphorylation and protease secretion using antibody arrays

Autor: Dave Finkel, Erin Eleria, Wen-Chieh Liao, Greta Wegner, Amy James

Publikováno v: Cancer Research. 74:3461-3461

The frequent deregulation of ERK signaling in tumors has led to the development of MEK inhibitors, which have proven to be clinically relevant to malignancies harboring BRAF mutations. Since proliferation and invasion are intertwined aspects of metas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5033fd65ed33a66b97f29c48fb344e9e
https://doi.org/10.1158/1538-7445.am2014-3461

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