Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Erin E. Grundy"'
Autor:
Erin E. Grundy, Lauren C. Shaw, Loretta Wang, Abigail V. Lee, James Castro Argueta, Daniel J. Powell, Mario Ostrowski, R. Brad Jones, C. Russell Y. Cruz, Heather Gordish-Dressman, Nicole P. Chappell, Catherine M. Bollard, Katherine B. Chiappinelli
Publikováno v:
Mobile DNA, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Transposable elements (TEs) are often expressed at higher levels in tumor cells than normal cells, implicating these genomic regions as an untapped pool of tumor-associated antigens. In ovarian cancer (OC), protein from the TE ERV-K is frequ
Externí odkaz:
https://doaj.org/article/ae60226c036b4df8a06919f4dc2441a1
Autor:
Dae Joong Kim, Swetha Anandh, Jamie L. Null, Piotr Przanowski, Sanchita Bhatnagar, Pankaj Kumar, Sarah E. Shelton, Erin E. Grundy, Katherine B. Chiappinelli, Roger D. Kamm, David A. Barbie, Andrew C. Dudley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Targeting DNA methyltransferase 1 (DNMT1) has immunomodulatory and anti-neoplastic activity, especially when paired with cancer immunotherapies. Here we explore the immunoregulatory functions of DNMT1 in the tumor vasculature of female mice.
Externí odkaz:
https://doaj.org/article/5ba899d284fd457f8d38e9095d8fd28e
Autor:
Katherine B. Chiappinelli, Stephen B. Baylin, Ting Wang, Reiner Strick, Pamela L. Strissel, Xiaoyun Xing, Michael J. Topper, Olivia Cox, Erin E. Grundy, Angela Yu, Stephanie Gomez, Uzma Rentia, Tomas Kanholm, Melissa Hadley, Elisa Arthofer, Noor Diab, James I. McDonald
Epithelial ovarian carcinomas are particularly deadly due to intratumoral heterogeneity, resistance to standard-of-care therapies, and poor response to alternative treatments such as immunotherapy. Targeting the ovarian carcinoma epigenome with DNA m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d898d23e497f1395dbbac63ffe031166
https://doi.org/10.1158/0008-5472.c.6513453.v1
https://doi.org/10.1158/0008-5472.c.6513453.v1
Autor:
Katherine B. Chiappinelli, Stephen B. Baylin, Ting Wang, Reiner Strick, Pamela L. Strissel, Xiaoyun Xing, Michael J. Topper, Olivia Cox, Erin E. Grundy, Angela Yu, Stephanie Gomez, Uzma Rentia, Tomas Kanholm, Melissa Hadley, Elisa Arthofer, Noor Diab, James I. McDonald
Supplementary Figure from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e34a195a2aed3778aaabda60767c09
https://doi.org/10.1158/0008-5472.22429785.v1
https://doi.org/10.1158/0008-5472.22429785.v1
Autor:
Katherine B. Chiappinelli, Stephen B. Baylin, Ting Wang, Reiner Strick, Pamela L. Strissel, Xiaoyun Xing, Michael J. Topper, Olivia Cox, Erin E. Grundy, Angela Yu, Stephanie Gomez, Uzma Rentia, Tomas Kanholm, Melissa Hadley, Elisa Arthofer, Noor Diab, James I. McDonald
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b6cac7a09216980d7200774c50a439
https://doi.org/10.1158/0008-5472.22429788.v1
https://doi.org/10.1158/0008-5472.22429788.v1
Autor:
Katherine B. Chiappinelli, Stephen B. Baylin, Ting Wang, Reiner Strick, Pamela L. Strissel, Xiaoyun Xing, Michael J. Topper, Olivia Cox, Erin E. Grundy, Angela Yu, Stephanie Gomez, Uzma Rentia, Tomas Kanholm, Melissa Hadley, Elisa Arthofer, Noor Diab, James I. McDonald
Supplementary Table from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818ab8fad5d90b63257bf5c83608134d
https://doi.org/10.1158/0008-5472.22429779
https://doi.org/10.1158/0008-5472.22429779
Autor:
Tomas Kanholm, Melissa Hadley, Reiner Strick, Erin E. Grundy, Ting Wang, Pamela L. Strissel, Stephanie Gomez, Angela Yu, Uzma Rentia, Noor Diab, Michael J. Topper, Stephen B. Baylin, James I. McDonald, Xiaoyun Xing, Katherine B. Chiappinelli, Olivia Cox, Elisa Arthofer
Publikováno v:
Cancer Research. 81:5176-5189
Epithelial ovarian carcinomas are particularly deadly due to intratumoral heterogeneity, resistance to standard-of-care therapies, and poor response to alternative treatments such as immunotherapy. Targeting the ovarian carcinoma epigenome with DNA m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff92c7a02b46f22144ea83787cf5a312
https://doi.org/10.1158/0008-5472.can-20-4243
https://doi.org/10.1158/0008-5472.can-20-4243
Publikováno v:
Cancer Research. 83:6020-6020
The purpose of this study was to understand the effect of p53 mutation status in ovarian cancer cells on the expression of repetitive elements (REs) following epigenetic treatment. High-grade serous ovarian carcinoma is the most aggressive subtype of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a493e3d8c0af087ddf826f04ff07319
https://doi.org/10.1158/1538-7445.am2023-6020
https://doi.org/10.1158/1538-7445.am2023-6020
Publikováno v:
The FEBS Journal. 289:1160-1179
Approximately 45% of the human genome is composed of transposable elements (TEs). Expression of these elements is tightly regulated during normal development. TEs may be expressed at high levels in embryonic stem cells but are epigenetically silenced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ae07eb93869dc463f8fef4909dbb58
https://doi.org/10.1111/febs.15722
https://doi.org/10.1111/febs.15722
Autor:
Stephanie Gomez, Olivia L Cox, Reddick R Walker, Uzma Rentia, Melissa Hadley, Elisa Arthofer, Noor Diab, Erin E Grundy, Tomas Kanholm, James I McDonald, Julie Kobyra, Erica Palmer, Satish Noonepalle, Alejandro Villagra, David Leitenberg, Catherine M Bollard, Yogen Saunthararajah, Katherine B Chiappinelli
Publikováno v:
Journal for ImmunoTherapy of Cancer. 10:e004974
BackgroundNovel therapies are urgently needed for ovarian cancer (OC), the fifth deadliest cancer in women. Preclinical work has shown that DNA methyltransferase inhibitors (DNMTis) can reverse the immunosuppressive tumor microenvironment in OC. Inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c8cc2a9f87f7c2a807e61e705834c0
https://doi.org/10.1136/jitc-2022-004974
https://doi.org/10.1136/jitc-2022-004974