The shape of pleomorphic virions determines resistance to cell-entry pressure

Autor: Meisui Liu, Tijana Ivanovic, Tian Li, Erin E Deans, Kartik Chandran, Eva Mittler, Zhenyu Li

Publikováno v: Nature Microbiology. 6:617-629

Many enveloped animal viruses produce a variety of particle shapes, ranging from small spherical to long filamentous types. Characterization of how the shape of the virion affects infectivity has been difficult because the shape is only partially gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35a7f64ed40d423b5892059f1977795
https://doi.org/10.1038/s41564-021-00877-0

Electrostatics Drive the Molecular Chaperone BiP to Preferentially Bind Oligomerized States of a Client Protein

Autor: Judy L.M. Kotler, Wei-Shao Wei, Erin E. Deans, Timothy Street

Publikováno v: J Mol Biol

Hsp70 chaperones bind short monomeric peptides with a weak characteristic affinity in the low micromolar range, but can also bind some aggregates, fibrils, and amyloids, with low nanomolar affinity. While this differential affinity enables Hsp70 to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8821666c5ae9451a2a6c470b7b956f8d
https://doi.org/10.1016/j.jmb.2022.167638

Structural cavities are critical to balancing stability and activity of a membrane-integral enzyme.

Autor: Guo R; Department of Chemistry, Michigan State University, East Lansing, MI 48824., Cang Z; Department of Mathematics, Michigan State University, East Lansing, MI 48824., Yao J; Department of Chemistry, Michigan State University, East Lansing, MI 48824., Kim M; Department of Chemistry, Michigan State University, East Lansing, MI 48824., Deans E; Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824., Wei G; Department of Mathematics, Michigan State University, East Lansing, MI 48824., Kang SG; Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598 sgkang@us.ibm.com honghd@msu.edu., Hong H; Department of Chemistry, Michigan State University, East Lansing, MI 48824; sgkang@us.ibm.com honghd@msu.edu.; Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 08; Vol. 117 (36), pp. 22146-22156. Date of Electronic Publication: 2020 Aug 26.