Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Autor: Paul Davies, Matthew J. Farrer, Eugenia Trushina, Liang Zhang, Bahareh Behrouz, Heather L. Melrose, Sarah Lincoln, Pamela J. McLean, T.A. Christenson, Andreas S. Schroeder, Mei Yue, John D. Fryer, Kelly M. Hinkle, Erin E. Bowles, Joel E. Beevers, Fabienne C. Fiesel, Aishe Kurti, Dennis W. Dickson, Austen J. Milnerwood, Wolfdieter Springer

Publikováno v: Neurobiology of Disease, Vol 78, Iss, Pp 172-195 (2015)

Mutations in the LRRK2 gene represent the most common genetic cause of late onset Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully determined but evidence points towards LRRK2 mutations causing a gain in kina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d73e694ee6a45a335775722f03599e
https://pubmed.ncbi.nlm.nih.gov/25836420

Digital Mammography and Breast Tomosynthesis Performance in Women with a Personal History of Breast Cancer, 2007-2016.

Autor: Lee JM; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.)., Ichikawa LE; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.)., Wernli KJ; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.)., Bowles E; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.)., Specht JM; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.)., Kerlikowske K; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.)., Miglioretti DL; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.)., Lowry KP; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.)., Tosteson ANA; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.)., Stout NK; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.)., Houssami N; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.)., Onega T; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.)., Buist DSM; From the Departments of Radiology (J.M.L., K.P.L.) and Medicine (J.M.S.), University of Washington School of Medicine, Seattle, Wash; Seattle Cancer Care Alliance, 1144 Eastlake Ave East, LG2-200, Seattle, WA 98109 (J.M.L., J.M.S., K.P.L.); Kaiser Permanente Washington Health Research Institute, Seattle, Wash (L.E.I., K.J.W., E.B., D.L.M., D.S.M.B.); Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif (K.J.W., D.S.M.B.); Department of Medicine, Division of General Internal Medicine, Department of Veterans Affairs, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif (K.K.); Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Davis, Calif (D.L.M.); Dartmouth Institute for Health Policy and Clinical Practice (A.N.A.T., T.O.) and Norris Cotton Cancer Center (A.N.A.T.), Geisel School of Medicine, Dartmouth College, Lebanon, NH; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard University, Boston, Mass (N.K.S.); Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, New South Wales, Australia (N.H.); and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (T.O.).

Publikováno v: Radiology [Radiology] 2021 Aug; Vol. 300 (2), pp. 290-300. Date of Electronic Publication: 2021 May 18.