Výsledky vyhledávání - "Erin E Henninger"

Telomere-driven mutational processes in yeast

Autor: Erin E. Henninger, Maria Teresa Teixeira

Publikováno v: Current Opinion in Genetics and Development
Current Opinion in Genetics and Development, Elsevier, 2020, 60, pp.99-106. ⟨10.1016/j.gde.2020.02.018⟩

International audience; Telomeres are part of the system that guards genome integrity in eukaryotes, protecting linear chromosomes from fusions and degradations. The protective functions of telomeres are put at risk in physiological situations where

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f073f92e769cde117717a0f214ab56c
https://hal.archives-ouvertes.fr/hal-03015050

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Author response: Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

Autor: Kimberly G. LeCompte, Bruce A. Bunnell, Karl P. Hodel, Richard de Borja, Adam Shlien, Erin E. Henninger, Zachary F. Pursell, A. Yasemin Göksenin, Tong Wu, Nathan Ungerleider, Nicholas Light, Uri Tabori, Brittany Campbell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c818e4daaf66e783373043a0519b44c
https://doi.org/10.7554/elife.32692.034

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Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

Autor: Tong Wu, Richard de Borja, Brittany Campbell, A. Yasemin Göksenin, Adam Shlien, Erin E. Henninger, Zachary F. Pursell, Karl P. Hodel, Kimberly G. LeCompte, Nicholas Light, Bruce A. Bunnell, Nathan Ungerleider, Uri Tabori

Publikováno v: eLife
eLife, eLife Sciences Publication, 2018, 7, pp.e32692. ⟨10.7554/eLife.32692⟩
eLife, Vol 7 (2018)

Tumors defective for DNA polymerase (Pol) ε proofreading have the highest tumor mutation burden identified. A major unanswered question is whether loss of Pol ε proofreading by itself is sufficient to drive this mutagenesis, or whether additional f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99f1cec74a31e230bbe621b2a8a3f4b
https://hal.sorbonne-universite.fr/hal-01737948/document

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Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

Autor: Adam, Shlien, Brittany B, Campbell, Richard, de Borja, Ludmil B, Alexandrov, Daniele, Merico, David, Wedge, Peter, Van Loo, Patrick S, Tarpey, Paul, Coupland, Sam, Behjati, Aaron, Pollett, Tatiana, Lipman, Abolfazl, Heidari, Shriya, Deshmukh, Na'ama, Avitzur, Bettina, Meier, Moritz, Gerstung, Ye, Hong, Diana M, Merino, Manasa, Ramakrishna, Marc, Remke, Roland, Arnold, Gagan B, Panigrahi, Neha P, Thakkar, Karl P, Hodel, Erin E, Henninger, A Yasemin, Göksenin, Doua, Bakry, George S, Charames, Harriet, Druker, Jordan, Lerner-Ellis, Matthew, Mistry, Rina, Dvir, Ronald, Grant, Ronit, Elhasid, Roula, Farah, Glenn P, Taylor, Paul C, Nathan, Sarah, Alexander, Shay, Ben-Shachar, Simon C, Ling, Steven, Gallinger, Shlomi, Constantini, Peter, Dirks, Annie, Huang, Stephen W, Scherer, Richard G, Grundy, Carol, Durno, Melyssa, Aronson, Anton, Gartner, M Stephen, Meyn, Michael D, Taylor, Zachary F, Pursell, Christopher E, Pearson, David, Malkin, P Andrew, Futreal, Michael R, Stratton, Eric, Bouffet, Cynthia, Hawkins, Peter J, Campbell, Uri, Tabori

Publikováno v: Nature Genetics. 47:257-262

DNA replication-associated mutations are repaired by two components: polymerase proofreading and mismatch repair. The mutation consequences of disruption to both repair components in humans are not well studied. We sequenced cancer genomes from child

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2872d9f4b6d4f6a48ba693ff41bee84f
https://doi.org/10.1038/ng.3202

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DNA polymerase ε and its roles in genome stability

Autor: Erin E. Henninger, Zachary F. Pursell

Publikováno v: IUBMB Life. 66:339-351

DNA Polymerase Epsilon (Pol e) is one of three DNA Polymerases (along with Pol δ and Pol α) required for nuclear DNA replication in eukaryotes. Pol e is comprised of four subunits, the largest of which is encoded by the POLE gene and contains the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49142dfa53b9286f20c9a7290b3f6003
https://doi.org/10.1002/iub.1276

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Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA

Autor: Robert L. Eoff, Sarah Eddy, Maroof K. Zafar, Leena Maddukuri, Erin E. Henninger, Zachary F. Pursell, Amit Ketkar

Publikováno v: Biochemistry. 54(20)

We have investigated the action of the human DNA polymerase epsilon (hpol ε) and eta (hpol η) catalytic cores on G-quadruplex (G4) DNA substrates derived from the promoter of the c-MYC proto-oncogene. The translesion enzyme hpol η exhibits a 6.2-f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c59893e381fc5364a7352dbf13865e
https://pubmed.ncbi.nlm.nih.gov/25903680

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