Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

Autor: Polina Kosillo, Kamran M Ahmed, Erin E Aisenberg, Vasiliki Karalis, Bradley M Roberts, Stephanie J Cragg, Helen S Bateup

Publikováno v: eLife, Vol 11 (2022)

The mTOR pathway is an essential regulator of cell growth and metabolism. Midbrain dopamine neurons are particularly sensitive to mTOR signaling status as activation or inhibition of mTOR alters their morphology and physiology. mTOR exists in two dis

Externí odkaz: https://doaj.org/article/7be27d522af2436c8c1b4b13a65c9cf5

Molecular recording of calcium concentration via calcium-dependent protein proximity labeling

Autor: J. Wren Kim, Adeline J. H. Yong, Erin E. Aisenberg, Wei Wang, Ted M. Dawson, Valina L. Dawson, Ruixuan Gao, Helen S. Bateup, Yuh Nung Jan, Nicholas T. Ingolia

Calcium ions serve as key intracellular signals. Local, transient increases in calcium concentrations can activate calcium sensor proteins that in turn trigger downstream effectors. In neurons, calcium transients play a central role in regulating neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57d9a41884a211638d9c5d6fc85fabff
https://doi.org/10.1101/2022.07.14.500122

Probing Neuropeptide Volume Transmission In Vivo by Simultaneous Near-Infrared Light-Triggered Release and Optical Sensing.

Autor: Xiong H; Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX 75080, USA., Lacin E; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029-5674, USA., Ouyang H; Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX 75080, USA., Naik A; Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA., Xu X; Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX 75080, USA., Xie C; Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX 75080, USA., Youn J; Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX 75080, USA., Wilson BA; Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX 75080, USA., Kumar K; School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA., Kern T; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029-5674, USA., Aisenberg E; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029-5674, USA., Kircher D; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029-5674, USA., Li X; Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX 75080, USA., Zasadzinski JA; Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA., Mateo C; Department of Physics, University of California at San Diego, La Jolla, CA 92093, USA., Kleinfeld D; Department of Physics, University of California at San Diego, La Jolla, CA 92093, USA., Hrabetova S; Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA., Slesinger PA; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029-5674, USA., Qin Z; Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX 75080, USA.; Department of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA.; Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Center for Advanced Pain Studies, The University of Texas at Dallas, Richardson, TX 75080, USA.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 Aug 22; Vol. 61 (34), pp. e202206122. Date of Electronic Publication: 2022 Jul 08.