Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Erin D Lew"'
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Akademický článek
Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities
Autor: Erin D Lew, Jennifer Oh, Patrick G Burrola, Irit Lax, Anna Zagórska, Paqui G Través, Joseph Schlessinger, Greg Lemke
Publikováno v: eLife, Vol 3 (2014)
The TAM receptor tyrosine kinases Tyro3, Axl, and Mer regulate key features of cellular physiology, yet the differential activities of the TAM ligands Gas6 and Protein S are poorly understood. We have used biochemical and genetic analyses to delineat
Externí odkaz: https://doaj.org/article/5fea7649da76453ba6611429febbdc74
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Immuno-oncological Efficacy of RXDX-106, a Novel TAM (TYRO3, AXL, MER) Family Small-Molecule Kinase Inhibitor
Autor: Marissa Chen, Jack Y. Lee, Yumi Yokoyama, Colin Walsh, Heather Vaaler, Patrick Fagan, Amy Diliberto, Jack D. Bui, Elizabeth A. Tindall, Joanne Oh, Amanda Albert, Robin Nevarez, Erin D. Lew, Ruth Seelige, Kathleen D. Tucker, Gary Li, Kristen M. Smith
Publikováno v: Cancer Research. 79:1996-2008
Expression of the TAM (TYRO3, AXL, MER) family of receptor tyrosine kinases (RTK) has been associated with cancer progression, metastasis, and drug resistance. In immune cells, TAM RTKs can dampen inflammation in favor of homeostatic wound-healing re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f1598638fc5b63bf285de1be86090d
https://doi.org/10.1158/0008-5472.can-18-2022
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5
Abstract 2672: ERAS-007 is a selective ERK1/2 inhibitor with preclinical activity across RAS/MAPK pathway-driven CRC models
Autor: Erin D. Lew, Joanne Oh, Taylor Congdon, Jingchuan Zhang, Robert F. Shoemaker
Publikováno v: Cancer Research. 82:2672-2672
Colorectal cancer (CRC) remains an unmet medical need where more than 50% off patients have tumors that are driven by somatic mutations in the RAS/MAPK signaling pathway. Targeted therapies, such as anti-EGFR inhibitors for patients with BRAFwt/RASwt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3449c5f620b7f5adda03d89d616c95e9
https://doi.org/10.1158/1538-7445.am2022-2672
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6
Abstract 2675: Discovery of potent CNS-penetrant covalent KRAS G12C inhibitors
Autor: Jae Hyun Bae, Erin D. Lew, Jun Feng, Marcos Gonzalez-Lopez, Joanne Oh, Patrick Fagan, Matt Salie, Nick Isley, Richard Lam, Adriana Irimia, Robin Nevarez, Bingzhen Lin, Taylor Congdon, Jingchuan Zhang, Dawei Xuan, Ping Chen, Jean-Michel Vernier, Robert Shoemaker
Publikováno v: Cancer Research. 82:2675-2675
The RAS family of GTPases, which include KRAS, NRAS, and HRAS, are key regulators of cellular signaling, acting as molecular switches downstream of receptor tyrosine kinases (RTKs) and as key regulators of the RAS/MAPK pathway. RAS cycles between ina
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33d4b3a75528e31caf66d2f6c649312d
https://doi.org/10.1158/1538-7445.am2022-2675
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7
Abstract 2669: ERAS-007 (ERK inhibitor) + ERAS-601 (SHP2 inhibitor) exhibit nonclinical combination activity across KRAS mutated NSCLC, CRC, and PDAC tumor models
Autor: Leenus Martin, Erin D. Lew, Roopal Patel, Joanne Oh, Jingchuan Zhang, Robin Nevarez, Taylor Congdon, Wei Lin, Les Brail, Robert Shoemaker
Publikováno v: Cancer Research. 82:2669-2669
KRAS mutations occur in about 25% of all cancers and promote oncogenesis via constitutive activation of the RAS/MAPK pathway. Targeting KRAS mutant tumors by inhibiting individual nodes in the RAS/MAPK pathway, including SHP2, SOS1, KRAS, RAF, MEK, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60b038ca8f5fed99c0184034f96168a6
https://doi.org/10.1158/1538-7445.am2022-2669
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8
TAM receptors regulate multiple features of microglial physiology
Autor: Greg Lemke, Yusuf Tufail, Humberto Leal-Bailey, Lawrence Fourgeaud, Patrick Burrola, Axel Nimmerjahn, Carla V. Rothlin, Paqui G. Través, Perri Callaway, Erin D. Lew, Anna Zagórska
Publikováno v: Nature. 532:240-244
Microglia are damage sensors for the central nervous system (CNS), and the phagocytes responsible for routine non-inflammatory clearance of dead brain cells. Here we show that the TAM receptor tyrosine kinases Mer and Axl regulate these microglial fu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957e009ac4fe003fb9a1b6e23706786c
https://doi.org/10.1038/nature17630
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9
The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity
Autor: Helen M. Lazear, Matthew J. Gorman, Greg Lemke, Erin D. Lew, Robyn S. Klein, Michael S. Diamond, Bimmi Shrestha, Jonathan J. Miner, José Luiz Proença-Módena, Brian P. Daniels
Publikováno v: Nature medicine
The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen host innate immune responses following engagement with their ligands Gas6 and Protein S, which recognize phosphatidylserine on apoptotic cells. In a form of apoptotic mi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120d7a816b9716000ea7df466fa83c57
https://doi.org/10.1038/nm.3974
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10
Diversification of TAM receptor tyrosine kinase function
Autor: Ian Dransfield, Greg Lemke, Paqui G. Través, Erin D. Lew, Anna Zagórska
Publikováno v: Nature immunology
Apoptotic cell clearance is critical for both tissue homeostasis and the resolution of inflammation. We found that the TAM receptor tyrosine kinases Axl and Mer played distinct roles as phagocytic receptors in these two settings, where they exhibited
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77b14e54a36f90a7652c8bebf597291
https://doi.org/10.1038/ni.2986
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