Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Erin C. Tracy"'
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11081 (2022)
To enhance uptake of photosensitizers by epithelial tumor cells by targeting these to EGFR, pyropheophorbide derivatives were synthesized that had erlotinib attached to different positions on the macrocycle. Although the addition of erlotinib reduced
Externí odkaz:
https://doaj.org/article/0ab10b4a84b14650b1ac35f92eaa691a
Publikováno v:
Frontiers in Physics, Vol 3 (2015)
We have applied continuous blood flow dynamics, quantified with diffuse correlation spectroscopy (DCS), in investigating photodynamic therapy (PDT) induced local photoreaction in a head and neck tumor model. Photoclor (0.47 µmol/kg) was intravenousl
Externí odkaz:
https://doaj.org/article/e0e1fcc06fe444268a8e4b2b5ecb7998
Autor:
Erin C. Tracy, Penny Joshi, Mykhaylo Dukh, Farukh A. Durrani, Ravindra K. Pandey, Heinz Baumann
Publikováno v:
Journal of Porphyrins and Phthalocyanines. :A-M
Photosensitizers currently used for photodynamic therapy of cancer show enhanced accumulation in tumor tissue but lack cancer cell specificity. To augment cellular uptake, the targeting of pyropheophorbide-a to carbohydrate-binding components of canc
Publikováno v:
Journal of photochemistry and photobiology. B, Biology. 234
Pheophorbide-based photosensitizers have demonstrated tumor cell-specific retention. The lead compound 3-[1'-hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH) in a clinical trial for photodynamic therapy of head and neck cancer lesions indicated a co
Autor:
Courtney Saenz, Manivannan Ethirajan, Erin C. Tracy, Mary-Jo Bowman, Joseph Cacaccio, Tymish Ohulchanskyy, Heinz Baumann, Ravindra K. Pandey
Publikováno v:
J Photochem Photobiol B
This study investigated the impact of anionic and cationic substituents of the pyropheophorbide-based photosensitizers (PS) on uptake and retention by tumor epithelial cells and photodynamic therapy (PDT). A series of PSs were generated that bear car