Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Erin C. Connolly"'
Autor:
Waaqo Daddacha, Allyson E. Koyen, Amanda J. Bastien, PamelaSara E. Head, Vishal R. Dhere, Geraldine N. Nabeta, Erin C. Connolly, Erica Werner, Matthew Z. Madden, Michele B. Daly, Elizabeth V. Minten, Donna R. Whelan, Ashley J. Schlafstein, Hui Zhang, Roopesh Anand, Christine Doronio, Allison E. Withers, Caitlin Shepard, Ranjini K. Sundaram, Xingming Deng, William S. Dynan, Ya Wang, Ranjit S. Bindra, Petr Cejka, Eli Rothenberg, Paul W. Doetsch, Baek Kim, David S. Yu
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1921-1935 (2017)
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associate
Externí odkaz:
https://doaj.org/article/0fff215953bf4b47a57af665f31bccaf
Publikováno v:
International Journal of Biological Sciences, Vol 8, Iss 7, Pp 964-978 (2012)
Many advanced tumors produce excessive amounts of Transforming Growth Factor-β (TGF-β) which, in normal epithelial cells, is a potent growth inhibitor. However, in oncogenically activated cells, the homeostatic action of TGF-β is often diverted al
Externí odkaz:
https://doaj.org/article/ff4489081a8a448a9dc638d2c6d62a72
Autor:
Matthew C. Woodruff, Richard P. Ramonell, Natalie S. Haddad, Fabliha A. Anam, Mark E. Rudolph, Tiffany A. Walker, Alexander D. Truong, Adviteeya N. Dixit, Jenny E. Han, Monica Cabrera-Mora, Martin C. Runnstrom, Regina Bugrovsky, Jennifer Hom, Erin C. Connolly, Igor Albizua, Vidhi Javia, Kevin S. Cashman, Doan C. Nguyen, Shuya Kyu, Ankur Singh Saini, Michael Piazza, Christopher M. Tipton, Arezou Khosroshahi, Greg Gibson, Greg S. Martin, Cheryl L. Maier, Annette Esper, Scott A. Jenks, F. Eun-Hyung Lee, Ignacio Sanz
Publikováno v:
medRxiv
Severe SARS-CoV-2 infection1 has been associated with highly inflammatory immune activation since the earliest days of the COVID-19 pandemic2–5. More recently, these responses have been associated with the emergence of self-reactive antibodies with
Metastasis is a multistep process that involves the deregulation of oncogenes and tumor suppressors beyond changes required for primary tumor formation. RHOB is known to have tumor suppressor activity, and its knockdown is associated with more aggres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327c863ebe93910282616187dc91339d
https://doi.org/10.1158/1541-7786.c.6542070
https://doi.org/10.1158/1541-7786.c.6542070
Supplementary Data from Overexpression of miR-21 Promotes an In vitro Metastatic Phenotype by Targeting the Tumor Suppressor RHOB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fced6e170ef5ff8d183e94c295418f
https://doi.org/10.1158/1541-7786.22518681.v1
https://doi.org/10.1158/1541-7786.22518681.v1
Autor:
Rosemary J. Akhurst, Jonathan M. Yingling, Byron Hann, Angela De Sapio, Minh Thu Luu, David Quigley, Elise F. Saunier, Erin C. Connolly
TGF-β is produced excessively by many solid tumors and can drive malignant progression through multiple effects on the tumor cell and microenvironment. TGF-β signaling pathway inhibitors have shown efficacy in preclinical models of metastatic cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da301134f8d9b0d8816d6197601967e7
https://doi.org/10.1158/0008-5472.c.6502956.v1
https://doi.org/10.1158/0008-5472.c.6502956.v1
Autor:
Rosemary J. Akhurst, Jonathan M. Yingling, Byron Hann, Angela De Sapio, Minh Thu Luu, David Quigley, Elise F. Saunier, Erin C. Connolly
Supplementary Figures 1-6, Tables 1-5 from Outgrowth of Drug-Resistant Carcinomas Expressing Markers of Tumor Aggression after Long-term TβRI/II Kinase Inhibition with LY2109761
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d829168a130122fca924dd248525229
https://doi.org/10.1158/0008-5472.22390449.v1
https://doi.org/10.1158/0008-5472.22390449.v1
Autor:
Rosemary J. Akhurst, Jonathan M. Yingling, Byron Hann, Angela De Sapio, Minh Thu Luu, David Quigley, Elise F. Saunier, Erin C. Connolly
Supplementary Figure Legends 1-6, Table Legends 1-5 from Outgrowth of Drug-Resistant Carcinomas Expressing Markers of Tumor Aggression after Long-term TβRI/II Kinase Inhibition with LY2109761
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38354950e295551cdaeb6a1b460c1041
https://doi.org/10.1158/0008-5472.22390452.v1
https://doi.org/10.1158/0008-5472.22390452.v1
Autor:
James M. Cook, Stewart Neil, Mohammad K. Khan, Brent D. Weinberg, Manali Rupji, Lindsey Lowder, Walter J. Curran, Andre J. Burnham, Tahseen H. Nasti, David H. Lawson, Erin C. Connolly, Milota Kaluzova, Daniel Pomeranz Krummel, Benjamin Izar, Havi Rosen, Guanguan Li, Andrew Jenkins, Laura Kallay, Matthew Schniederjan, Jeanne Kowalski, Jing Su, Havva Keskin, Jeffrey J. Olson, Soma Sengupta, Mark Thomas, Ragini R. Kudchadkar, Maxwell Xu, Taukir Ahmed, Robert H. Press
Publikováno v:
Neuro Oncol
Melanoma brain metastases (MBM) occur in ~50% of advanced melanoma patients. It is unclear if systemic therapies synergize with radiotherapy (RT) and what the impact of RT timing has on efficacy. We find that RT followed by ICI (immune checkpoint inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ec9a7333b86c2994fe6ca5cee54edd
https://europepmc.org/articles/PMC6847525/
https://europepmc.org/articles/PMC6847525/
Autor:
Waaqo Daddacha, Hui Zhang, Ashley J. Schlafstein, Michele B. Daly, Baek Kim, Petr Cejka, Vishal R. Dhere, Ya Wang, Geraldine N. Nabeta, William S. Dynan, PamelaSara E. Head, Allison E. Withers, Paul W. Doetsch, Ranjini K. Sundaram, Elizabeth V. Minten, Donna R. Whelan, Allyson E. Koyen, Caitlin Shepard, Amanda J. Bastien, Ranjit S. Bindra, Erica Werner, David S. Yu, Matthew Z. Madden, Christine Doronio, Roopesh Anand, Xingming Deng, Erin C. Connolly, Eli Rothenberg
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1921-1935 (2017)
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84766c3ec7cb3d4b69a5881fe03a7d0c
http://doc.rero.ch/record/327163/files/Daddacha_CR_2017.pdf
http://doc.rero.ch/record/327163/files/Daddacha_CR_2017.pdf