Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Erin C. Berthold"'
Autor:
Erin C. Berthold, Shyam H. Kamble, Siva Rama Raju Kanumuri, Michelle A. Kuntz, Alexandria S. Senetra, Yi-Hua Chiang, Sushobhan Mukhopadhyay, Christopher R. McCurdy, Abhisheak Sharma
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 318 (2024)
Kratom and cannabidiol products are used to self-treat a variety of conditions, including anxiety and pain, and to elevate mood. Research into the individual pharmacokinetic properties of commercially available kratom and cannabidiol products has bee
Externí odkaz:
https://doaj.org/article/1896d11b881d4b36b3b8b9220d43cfab
Autor:
Shyam H. Kamble, Samuel Obeng, Francisco León, Luis F. Restrepo, Tamara I. King, Erin C. Berthold, Siva Rama Raju Kanumuri, Lea R. Gamez-Jimenez, Victoria L.C. Pallares, Avi Patel, Nicholas P. Ho, Aidan Hampson, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson, Abhisheak Sharma, Takato Hiranita
Publikováno v:
J Pharmacol Exp Ther
Mitragynine, an opioidergic alkaloid present in Mitragyna speciosa (kratom), is metabolized by cytochrome P450 3A (CYP3A) to 7-hydroxymitragynine, a more potent opioid receptor agonist. The extent to which conversion to 7-hydroxymitragynine mediates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9288dd2b6b7ca7f4d59c89456a88b52
https://doi.org/10.1124/jpet.122.001525
https://doi.org/10.1124/jpet.122.001525
Autor:
Panayotis Thanos, Samantha Lane Penman, Erin C Berthold, Abrianna Mihalkovic, Nikki Hammond, Christopher R McCurdy, Rina D Eiden, Abhisheak Sharma
Publikováno v:
Current Pharmaceutical Design. 29
Background: Delta-9-tetrahydrocannabinol (THC) is the main psychoactive component of cannabis. Historically, rodent studies examining the effects of THC have used intraperitoneal injection as the route of administration, heavily focusing on male subj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20dc24466c265dff04aae1f9b7111baa
https://doi.org/10.2174/1381612829666230419093809
https://doi.org/10.2174/1381612829666230419093809
Autor:
Shyam H. Kamble, Erin C. Berthold, Siva Rama Raju Kanumuri, Tamara I. King, Michelle A. Kuntz, Francisco León, Marco Mottinelli, Lance R. McMahon, Christopher R. McCurdy, Abhisheak Sharma
Publikováno v:
The AAPS Journal. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccda6d4cc19c400bb1ffe6113bb47dde
https://doi.org/10.1208/s12248-022-00736-8
https://doi.org/10.1208/s12248-022-00736-8
Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy
Autor:
Abhisheak Sharma, Christopher R. McCurdy, Carolina Lopera-Londoño, Tamara I. King, Bonnie A. Avery, Shyam H. Kamble, Lance R. McMahon, Francisco León, Aidan J. Hampson, Kanumuri Siva Rama Raju, Erin C. Berthold
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Kratom is widely consumed in the United States for self-treatment of pain and opioid withdrawal symptoms. Mitragynine is the most abundant alkaloid in kratom and is a μ-opioid receptor agonist. 7-Hydroxymitragynine (7-HMG) is a mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c306b2f68f1c6ee8f03b1378212d38
https://doi.org/10.1021/acsptsci.0c00075
https://doi.org/10.1021/acsptsci.0c00075
Autor:
Kanumuri Siva Rama Raju, Erin C. Berthold, Elizabeth A. Maxwell, Francisco León, Abhisheak Sharma, Christopher R. McCurdy, Bonnie A. Avery, Tamara I. King, Lance R. McMahon, Shyam H. Kamble
Publikováno v:
Planta Med
Mitragynine is the most abundant psychoactive alkaloid derived from the leaves of Mitragyna speciosa (kratom), a tropical plant indigenous to regions of Southeast Asia. Mitragynine displays a moderate affinity to opioid receptors, and kratom is often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816a91eec47a9a981553301f0dee3ee3
https://doi.org/10.1055/a-1212-5475
https://doi.org/10.1055/a-1212-5475
Autor:
Rui Yang, Sarah da Silva Benevenute, Erin C. Berthold, Jim Freeman, Zachary T. Brym, Christopher R. McCurdy
Publikováno v:
Journal of Agricultural and Food Chemistry. 68:6058-6064
A field study was performed to investigate the development of cannabinoids in flowers of industrial hemp using three day-length-sensitive and two day-length-neutral varieties. Flower samples were analyzed for cannabinoids on a weekly basis from 2 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dcae08b366eb5771d96f0484ad8b7f8
https://doi.org/10.1021/acs.jafc.0c01211
https://doi.org/10.1021/acs.jafc.0c01211
Autor:
Luis F. Restrepo, Erin C. Berthold, Aidan J. Hampson, Avi Patel, Lance R. McMahon, Carolina Lopera-Londoño, Takato Hiranita, Shyam H. Kamble, Samuel Obeng, Abhisheak Sharma, Lea R. Gamez-Jimenez, Francisco León, Clinton E. Canal, Marco Mottinelli, Christopher R. McCurdy, Yiming Chen, Tamara I. King
Publikováno v:
J Med Chem
Kratom alkaloids have mostly been evaluated for their opioid activity but less at other targets that could contribute to their physiological effects. Here, we investigated the in vitro and in vivo activity of kratom alkaloids at serotonin receptors (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749b326c3ebef7e4aed6ae82cdd6614a
https://europepmc.org/articles/PMC9235362/
https://europepmc.org/articles/PMC9235362/
Autor:
Francisco León, Tamara I. King, Christopher R. McCurdy, Nelson Jeng Yeou Chear, Bonnie A. Avery, Surash Ramanathan, Abhisheak Sharma, Shyam H. Kamble, Erin C. Berthold
Publikováno v:
Drug Test Anal
Kratom (Mitragyna speciosa) is a psychoactive plant popular in the United States for the self-treatment of pain and opioid addiction. For standardization and quality control of raw and commercial kratom products, an ultra-performance liquid chromatog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc4e768f1ddbc86c388d234a32cddc6
https://doi.org/10.1002/dta.2604
https://doi.org/10.1002/dta.2604
Autor:
Abhisheak Sharma, Elizabeth A. Maxwell, Aidan J. Hampson, Francisco León, Kanumuri Siva Rama Raju, Lance R. McMahon, Tamara I. King, Shyam H. Kamble, Erin C. Berthold, Christopher R. McCurdy
Publikováno v:
Eur J Drug Metab Pharmacokinet
BACKGROUND AND OBJECTIVES: 7-Hydroxymitragynine (7-HMG) is an oxidative metabolite of mitragynine, the most abundant alkaloid in the leaves of Mitragyna speciosa (otherwise known as kratom). While mitragynine is a weak partial μ-opioid receptor (MOR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1555b6c43c5f6d42e3ecb78abb2a51
https://pubmed.ncbi.nlm.nih.gov/33847897
https://pubmed.ncbi.nlm.nih.gov/33847897