Výsledky vyhledávání - "Erin A Kuether"

Thromboelastometry assessment of hemostatic properties in various murine models with coagulopathy and the effect of factor VIII therapeutics

Autor: Hartmut Weiler, Juan Fang, Qizhen Shi, Robert R. Montgomery, David A. Wilcox, Jocelyn A. Schroeder, Erin A Kuether, Weiqing Jing

Publikováno v: J Thromb Haemost

BACKGROUND: Rotational thromboelastometry (ROTEM) has been commonly used to assess the viscoelastic properties of the blood clotting process in the clinic for patients with a hemostatic or prothrombotic disorder. OBJECTIVE: To evaluate the capability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a4f2bb6666afac592f643dc292c337
https://doi.org/10.1111/jth.15456

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Platelet gene therapy corrects the hemophilic phenotype in immunocompromised hemophilia A mice transplanted with genetically manipulated human cord blood stem cells

Autor: Erin L. Kuether, Scot A. Fahs, Qizhen Shi, Robert R. Montgomery, Yingyu Chen, Jocelyn A. Schroeder

Publikováno v: Blood. 123:395-403

Our previous studies have demonstrated that platelet FVIII (2bF8) gene therapy can improve hemostasis in hemophilia A mice, even in the presence of inhibitory antibodies, but none of our studies has targeted human cells. Here, we evaluated the feasib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d266fafb883c1632eedeeb2858753f19
https://doi.org/10.1182/blood-2013-08-520478

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Platelet Gene Therapy by Lentiviral Gene Delivery to Hematopoietic Stem Cells Restores Hemostasis and Induces Humoral Immune Tolerance in FIXnull Mice

Autor: Yingyu Chen, Qizhen Shi, Jocelyn A. Schroeder, Guowei Zhang, Erin L. Kuether

Publikováno v: Molecular Therapy. 22:169-177

Here, we developed a clinically translatable platelet gene therapy approach for hemophilia B. Platelet-targeted FIX (2bF9) expression was introduced by transplantation of hematopoietic stem cells (HSCs) transduced with 2bF9 lentivirus (LV). Sustained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d57ce0affc531429033f144e0d814a
https://doi.org/10.1038/mt.2013.197

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Factor VIII inhibitors: von Willebrand factor makes a difference in vitro and in vivo

Autor: J. Cox Gill, Qizhen Shi, Erin L. Kuether, Jocelyn A. Schroeder, Robert R. Montgomery, Scot A. Fahs, C. L. Perry

Publikováno v: Journal of Thrombosis and Haemostasis. 10:2328-2337

Summary. Background: The important association between von Willebrand factor (VWF) and factor VIII (FVIII) has been investigated for decades, but the effect of VWF on the reactivity of FVIII inhibitory antibodies, referred to as inhibitors, is still

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7220dfbd15dd6d36dfcc7b42e29cd8ae
https://doi.org/10.1111/j.1538-7836.2012.04902.x

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Correction of Murine Bernard–Soulier Syndrome by Lentivirus-mediated Gene Therapy

Autor: Jocelyn A. Schroeder, Scot A. Fahs, Erin L. Kuether, Robert R. Montgomery, Jerry Ware, Sachiko Kanaji, Qizhen Shi

Publikováno v: Molecular Therapy. 20:625-632

Bernard-Soulier syndrome (BSS) is an inherited bleeding disorder caused by a defect in the platelet glycoprotein (GP) Ib-IX-V complex. The main treatment for BSS is platelet transfusion but it is often limited to severe bleeding episodes or surgical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555ab4a1d8b9e21f08eb9891ffaf0e6b
https://doi.org/10.1038/mt.2011.231

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Intravascular recovery of VWF and FVIII following intraperitoneal injection and differences from intravenous and subcutaneous injection in mice

Autor: Jocelyn A. Schroeder, Erin L. Kuether, Robert R. Montgomery, Scot A. Fahs, Qizhen Shi

Publikováno v: Haemophilia. 18:639-646

Intravenous infusion studies in humans suggest that both von Willebrand factor (VWF) and factor VIII (FVIII) remain intravascular in contrast to other coagulation proteins. We explored whether infusion of VWF and FVIII by either intraperitoneal (i.p.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0ebcc1274ce99452bd1a0b99e43ee85
https://doi.org/10.1111/j.1365-2516.2011.02735.x

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Targeting FVIII expression to endothelial cells regenerates a releasable pool of FVIII and restores hemostasis in a mouse model of hemophilia A

Autor: Erin L. Kuether, Qizhen Shi, Hartmut Weiler, Brian C. Cooley, Scot A. Fahs, Robert R. Montgomery

Publikováno v: Blood. 116:3049-3057

The natural cell type(s) that synthesize and release factor VIII (FVIII) into the circulation are still not known with certainty. In vitro studies indicate that artificial expression of FVIII in endothelial cells produces an intracellular pool of FVI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b983d4f0b225e646db37a9c46e8d601
https://doi.org/10.1182/blood-2010-03-272419

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Factor IX ectopically expressed in platelets can be stored in α-granules and corrects the phenotype of hemophilia B mice

Autor: Christopher E. Walsh, Qizhen Shi, Erin L. Kuether, Guowei Zhang, Scot A. Fahs, Robert R. Montgomery

Publikováno v: Blood. 116:1235-1243

We developed 2bF9 transgenic mice in a hemophilia B mouse model with the expression of human factor IX (FIX) under control of the platelet-specific integrin αIIb promoter, to determine whether ectopically expressing FIX in megakaryocytes can enable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdeb3b7794241779b7acc44d7297d8f5
https://doi.org/10.1182/blood-2009-11-255612

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Syngeneic transplantation of hematopoietic stem cells that are genetically modified to express factor VIII in platelets restores hemostasis to hemophilia A mice with preexisting FVIII immunity

Autor: Erin L. Kuether, David A. Wilcox, Scot A. Fahs, Patricia A. Morateck, Hartmut Weiler, Robert R. Montgomery, Nicole Mareno, Qizhen Shi

Publikováno v: Blood. 112(7)

Although genetic induction of factor VIII (FVIII) expression in platelets can restore hemostasis in hemophilia A mice, this approach has not been studied in the clinical setting of preexisting FVIII inhibitory antibodies to determine whether such ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffe3f50671b0176e38f0cd8ec311b7e
https://pubmed.ncbi.nlm.nih.gov/18809765

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Lentivirus-Mediated Platelet Gene Therapy Corrects Bleeding Diathesis and Induces Immune Tolerance in Murine Hemophilia B Mice

Autor: Erin L. Kuether, Jocelyn A. Schroeder, Robert R. Montgomery, Yingyu Chen, Guowei Zhang, Qizhen Shi

Publikováno v: Blood. 120:1101-1101

Abstract 1101 While data from the clinical trials using AAV vector expression FIX in hemophilia B gene therapy in humans are very encouraging, for individuals with severe liver disease or neutralizing antibodies to AAV, an alternative gene therapy ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bad4d84ef21d4722715dc1bdd81cd5da
https://doi.org/10.1182/blood.v120.21.1101.1101

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