Výsledky vyhledávání - "Erin, Joseph"

Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

Autor: John S. Lazo, Robert A. Parise, Erin Joseph, Julie L. Eiseman, Jianxia Guo, Merrill J. Egorin, Edward V. Prochownik

Publikováno v: Cancer Chemotherapy and Pharmacology. 63:615-625

c-Myc is commonly activated in many human tumors and is functionally important in cellular proliferation, differentiation, apoptosis and cell cycle progression. The activity of c-Myc requires noncovalent interaction with its client protein Max. In vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526dcc229b74e5650b7a77b04d255d5e
https://doi.org/10.1007/s00280-008-0774-y

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Plasma and tissue disposition of non-liposomal DB-67 and liposomal DB-67 in C.B-17 SCID mice

Autor: Laura L. Jung, Julie L. Eiseman, William C. Zamboni, Sandra Strychor, Sarah A. Fetterman, Beth A. Zamboni, Erin Joseph, Dennis P. Curran, Thomas G. Burke, Brian Sidone

Publikováno v: Investigational New Drugs. 26:399-406

Purpose: DB-67 is a silatecan, 7-silyl-modified camptothecin, with enhanced lipophilicity and increased blood stability of the active-lactone ring. The generation of a liposomal formulation of DB-67 may be an attractive method of intravenous (IV) adm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9cb35ba99a81891661c73b2cc7159b9
https://doi.org/10.1007/s10637-007-9109-9

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Noninvasive and nondestructive optical spectroscopic measurement of motexafin gadolinium in mouse tissues: Comparison to high-performance liquid chromatography

Autor: Jianxia Guo, Stephen C. Kanick, Robert S. Parker, Julie L. Eiseman, Erin Joseph

Publikováno v: Journal of Photochemistry and Photobiology B: Biology. 88:90-104

Efficient design of anti-cancer treatments involving radiation- and photo-sensitizing therapeutics requires knowledge of tissue-specific drug concentrations. This study investigates the use of the optical pharmacokinetic system (OPS) to measure conce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e95cb7dcb782ca3493e508dfac232c
https://doi.org/10.1016/j.jphotobiol.2007.05.002

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Quantitative determination of the cytidine deaminase inhibitor tetrahydrouridine (THU) in mouse plasma by liquid chromatography/electrospray ionization tandem mass spectrometry

Autor: Robert A. Parise, Jan H. Beumer, Joseph M. Covey, Julie L. Eiseman, Erin Joseph, Merrill J. Egorin

Publikováno v: Rapid Communications in Mass Spectrometry. 21:1991-1997

A number of anticancer drugs are cytidine analogues that undergo metabolic deactivation catalyzed by cytidine deaminase (CD). 3,4,5,6-Tetrahydrouridine (THU) is a potent inhibitor of CD, by acting as a transition-state analogue of its natural substra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502a6258538623c90eb2d51ea7163d8d
https://doi.org/10.1002/rcm.3054

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A Mass Balance and Disposition Study of the DNA Methyltransferase Inhibitor Zebularine (NSC 309132) and Three of Its Metabolites in Mice

Autor: Joseph M. Covey, Robert S. Parker, Erin Joseph, Jan H. Beumer, Merrill J. Egorin, Julie L. Eiseman, David Z. D'Argenio

Publikováno v: Clinical Cancer Research. 12:5826-5833

Purpose: To elucidate the in vivo metabolic fate of zebularine (NSC 309132), a DNA methyltransferase inhibitor proposed for clinical evaluation in the treatment of cancer. Experimental Design: Male, CD2F1 mice were dosed i.v. with 100 mg/kg 2-[14C]ze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09340fd1b1d2aad8da9a26d3a0125558
https://doi.org/10.1158/1078-0432.ccr-06-1234

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Relationship between Plasma Exposure of 9-Nitrocamptothecin and Its 9-Aminocamptothecin Metabolite and Antitumor Response in Mice Bearing Human Colon Carcinoma Xenografts

Autor: Merrill J. Egorin, Sandra Strychor, Ramesh K. Ramanathan, William C. Zamboni, Julie L. Eiseman, Erin Joseph, Laura L. Jung, Deborah R. Hamburger, Ruzhi Jin

Publikováno v: Clinical Cancer Research. 11:4867-4874

9-Nitrocamptothecin has completed phase III studies in patients with newly diagnosed and refractory pancreatic cancer; however, the optimal 9-nitrocamptothecin treatment regimen is unclear. We used an intermittent schedule of 9-nitrocamptothecin to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eadfab5b9afc4bfceed86ee8a545289
https://doi.org/10.1158/1078-0432.ccr-05-0144

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Plasma Pharmacokinetics, Oral Bioavailability, and Interspecies Scaling of the DNA Methyltransferase Inhibitor, Zebularine

Autor: Alexander V. Lyubimov, Joseph M. Covey, Ya Fei Chen, Julie L. Eiseman, Julianne L. Holleran, Erin Joseph, Robert A. Parise, Merrill J. Egorin, Elizabeth R. Glaze, David Z. D'Argenio

Publikováno v: Clinical Cancer Research. 11:3862-3868

Purpose: Zebularine is a DNA methyltransferase inhibitor proposed for clinical evaluation. Experimental Design: We developed a liquid chromatography/mass spectrometry assay and did i.v. and oral studies in mice, rats, and rhesus monkeys. Results: In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948175a27d663a9f971dce2d8a9e7deb
https://doi.org/10.1158/1078-0432.ccr-04-2406

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N-(2-Hydroxypropyl)methacrylamide Copolymers of a Glutathione (GSH)-Activated Glyoxalase I Inhibitor and DNA Alkylating Agent: Synthesis, Reaction Kinetics with GSH, and in Vitro Antitumor Activities

Autor: Julie L. Eiseman, Guozhang Zhu, Donald J. Creighton, Erin Joseph, Heekyung Tak, Zhe-Bin Zheng

Publikováno v: Bioconjugate Chemistry. 16:598-607

The incorporation of anticancer prodrugs into polyacrylamide conjugates has been shown to improve tumor targeting via the so-called "enhanced permeability and retention" effect. This strategy has now been expanded to include two different classes of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf7fc6fec4df3a985d9e0326ce96d57
https://doi.org/10.1021/bc0499634

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Plasma pharmacokinetics and tissue distribution of the breast cancer resistance protein (BCRP/ABCG2) inhibitor fumitremorgin C in SCID mice bearing T8 tumors

Autor: J. T. Mondick, Tushar S. Garimella, Julie L. Eiseman, Kenneth S. Bauer, Takeo Nakanishi, Erin Joseph, Douglas D. Ross, Susan E. Bates

Publikováno v: Cancer Chemotherapy and Pharmacology. 55:101-109

Multidrug resistance (MDR) remains a major obstacle in the treatment of human cancers. The recently discovered breast cancer resistance protein (BCRP/ABCG2) has been found to be an important mediator of chemotherapeutic MDR. Fumitremorgin C (FTC) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2c9b072a5f540e342ea5ea315cfb71
https://doi.org/10.1007/s00280-004-0866-2

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Distribution of 1-(2-Deoxy-2-fluoro-β-d-arabinofuranosyl) Uracil in Mice Bearing Colorectal Cancer Xenografts

Autor: Merrill J. Egorin, Clive Brown-Proctor, Paul E. Kinahan, Chester A. Mathis, Jerry M. Collins, Deborah R. Hamburger, Julie L. Eiseman, Erin Joseph, Raymond W. Klecker, Lawrence W. Anderson, Su-Shu Pan

Publikováno v: Clinical Cancer Research. 10:6669-6676

Purpose: In colorectal, breast, and head and neck cancers, response to 5-fluorouracil is associated with low expression of thymidylate synthase. In contrast, tumors with high expression of thymidylate synthase may be more sensitive to prodrugs such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf03e2f44fc0a39ba607450c0904f2f4
https://doi.org/10.1158/1078-0432.ccr-03-0686

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