The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study.

Autor: Eriksen, Rebeca, White, Margaret C, Dawed, Adem Y, Perez, Isabel Garcia, Posma, Joram M, Haid, Mark, Sharma, Sapna, Prehn, Cornelia, Thomas, E Louise, Koivula, Robert W, Bizzotto, Roberto, Mari, Andrea, Giordano, Giuseppe N, Pavo, Imre, Schwenk, Jochen M, Masi, Federico De, Tsirigos, Konstantinos D, Brunak, Søren, Viñuela, Ana, Mahajan, Anubha

Publikováno v: Journal of Clinical Endocrinology & Metabolism; Sep2024, Vol. 109 Issue 9, pe1697-e1707, 11p

Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Autor: Allesøe, Rosa Lundbye, Lundgaard, Agnete Troen, Hernández Medina, Ricardo, Aguayo-Orozco, Alejandro, Johansen, Joachim, Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, Lili, Biel, Jorge Hernansanz, Brasas, Valentas, Webel, Henry, Benros, Michael Eriksen, Pedersen, Anders Gorm, Chmura, Piotr Jaroslaw, Jacobsen, Ulrik Plesner, Mari, Andrea, Koivula, Robert, Mahajan, Anubha, Vinuela, Ana, Tajes, Juan Fernandez, Sharma, Sapna, Haid, Mark, Hong, Mun-Gwan, Musholt, Petra B., de Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, Gwen, Bell, Jimmy, Thomas, E. Louise, Frost, Gary, Thomsen, Henrik, Hansen, Elizaveta, Hansen, Tue Haldor, Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T., ‘t Hart, Leen M., Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, Jane, Hattersley, Andrew, McDonald, Timothy, Ridderstråle, Martin, Walker, Mark, Forgie, Ian, Giordano, Giuseppe N., Pavo, Imre, Ruetten, Hartmut, Pedersen, Oluf, Hansen, Torben, Dermitzakis, Emmanouil, Franks, Paul W., Schwenk, Jochen M., Adamski, Jerzy, McCarthy, Mark I., Pearson, Ewan, Banasik, Karina, Rasmussen, Simon, Brunak, S. ren, Froguel, Philippe, Thomas, Cecilia Engel, Haussler, Ragna, Beulens, Joline, Rutters, Femke, Nijpels, Giel, van Oort, Sabine, Groeneveld, Lenka, Elders, Petra, Giorgino, Toni, Rodriquez, Marianne, Nice, Rachel, Perry, Mandy, Bianzano, Susanna, Graefe-Mody, Ulrike, Hennige, Anita, Grempler, Rolf, Baum, Patrick, Stærfeldt, Hans-Henrik, Shah, Nisha, Teare, Harriet, Ehrhardt, Beate, Tillner, Joachim, Dings, Christiane, Lehr, Thorsten, Scherer, Nina, Sihinevich, Iryna, Cabrelli, Louise, Loftus, Heather, Bizzotto, Roberto, Tura, Andrea, Dekkers, Koen, van Leeuwen, Nienke, Groop, Leif, Slieker, Roderick, Ramisch, Anna, Jennison, Christopher, McVittie, Ian, Frau, Francesca, Steckel-Hamann, Birgit, Adragni, Kofi, Thomas, Melissa, Pasdar, Naeimeh Atabaki, Fitipaldi, Hugo, Kurbasic, Azra, Mutie, Pascal, Pomares-Millan, Hugo, Bonnefond, Amelie, Canouil, Mickael, Caiazzo, Robert, Verkindt, Helene, Holl, Reinhard, Kuulasmaa, Teemu, Deshmukh, Harshal, Cederberg, Henna, Laakso, Markku, Vangipurapu, Jagadish, Dale, Matilda, Thorand, Barbara, Nicolay, Claudia, Fritsche, Andreas, Hill, Anita, Hudson, Michelle, Thorne, Claire, Allin, Kristine, Arumugam, Manimozhiyan, Jonsson, Anna, Engelbrechtsen, Line, Forman, Annemette, Dutta, Avirup, Sondertoft, Nadja, Fan, Yong, Gough, Stephen, Robertson, Neil, McRobert, Nicky, Wesolowska-Andersen, Agata, Brown, Andrew, Davtian, David, Dawed, Adem, Donnelly, Louise, Palmer, Colin, White, Margaret, Ferrer, Jorge, Whitcher, Brandon, Artati, Anna, Prehn, Cornelia, Adam, Jonathan, Grallert, Harald, Gupta, Ramneek, Sackett, Peter Wad, Nilsson, Birgitte, Tsirigos, Konstantinos, Eriksen, Rebeca, Jablonka, Bernd, Uhlen, Mathias, Gassenhuber, Johann, Baltauss, Tania, de Preville, Nathalie, Klintenberg, Maria, Abdalla, Moustafa

Publikováno v: Allesøe, R L, Lundgaard, A T, Hernández Medina, R, Aguayo-Orozco, A, Johansen, J, Nissen, J N, Brorsson, C, Mazzoni, G, Niu, L, Biel, J H, Brasas, V, Webel, H, Benros, M E, Pedersen, A G, Chmura, P J, Jacobsen, U P, Mari, A, Koivula, R, Mahajan, A, Vinuela, A, Tajes, J F, Sharma, S, Haid, M, Hong, M-G, Musholt, P B, de Masi, F, Vogt, J, Pedersen, H K, Gudmundsdottir, V, Jones, A, Kennedy, G, Bell, J, Thomas, E L, Frost, G, Thomsen, H, Hansen, E, Hansen, T H, Vestergaard, H, Muilwijk, M, Blom, M T, ‘t Hart, L M, Pattou, F, Raverdy, V, Brage, S, Kokkola, T, Heggie, A, McEvoy, D, Mourby, M, Kaye, J, Hattersley, A, McDonald, T, Ridderstråle, M, Walker, M, Forgie, I, Giordano, G N, Pavo, I, Ruetten, H, Pedersen, O, Hansen, T, Dermitzakis, E, Franks, P W, Schwenk, J M, Adamski, J, McCarthy, M I, Pearson, E, Banasik, K, Rasmussen, S, Brunak, S R, Froguel, P, Thomas, C E, Haussler, R, Beulens, J, Rutters, F, Nijpels, G, van Oort, S, Groeneveld, L, Elders, P, Giorgino, T, Rodriquez, M, Nice, R, Perry, M, Bianzano, S, Graefe-Mody, U, Hennige, A, Grempler, R, Baum, P, Stærfeldt, H-H, Shah, N, Teare, H, Ehrhardt, B, Tillner, J, Dings, C, Lehr, T, Scherer, N, Sihinevich, I, Cabrelli, L, Loftus, H, Bizzotto, R, Tura, A, Dekkers, K, van Leeuwen, N, Groop, L, Slieker, R, Ramisch, A, Jennison, C, McVittie, I, Frau, F, Steckel-Hamann, B, Adragni, K, Thomas, M, Pasdar, N A, Fitipaldi, H, Kurbasic, A, Mutie, P, Pomares-Millan, H, Bonnefond, A, Canouil, M, Caiazzo, R, Verkindt, H, Holl, R, Kuulasmaa, T, Deshmukh, H, Cederberg, H, Laakso, M, Vangipurapu, J, Dale, M, Thorand, B, Nicolay, C, Fritsche, A, Hill, A, Hudson, M, Thorne, C, Allin, K, Arumugam, M, Jonsson, A, Engelbrechtsen, L, Forman, A, Dutta, A, Sondertoft, N, Fan, Y, Gough, S, Robertson, N, McRobert, N, Wesolowska-Andersen, A, Brown, A, Davtian, D, Dawed, A, Donnelly, L, Palmer, C, White, M, Ferrer, J, Whitcher, B, Artati, A, Prehn, C, Adam, J, Grallert, H, Gupta, R, Sackett, P W, Nilsson, B, Tsirigos, K, Eriksen, R, Jablonka, B, Uhlen, M, Gassenhuber, J, IMI DIRECT Consortium, Baltauss, T, de Preville, N, Klintenberg, M & Abdalla, M 2023, ' Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models ', Nature Biotechnology, vol. 41, no. 3, pp. 399-408 . https://doi.org/10.1038/s41587-022-01520-x
Nature Biotechnology, 41(3), 399-408. Nature Publishing Group
Allesøe, R L, Lundgaard, A T, Hernández Medina, R, Aguayo-Orozco, A, Johansen, J, Nissen, J N, Brorsson, C, Mazzoni, G, Niu, L, Biel, J H, Brasas, V, Webel, H, Benros, M E, Pedersen, A G, Chmura, P J, Jacobsen, U P, Mari, A, Koivula, R, Mahajan, A, Vinuela, A, Tajes, J F, Sharma, S, Haid, M, Hong, M G, Musholt, P B, De Masi, F, Vogt, J, Pedersen, H K, Gudmundsdottir, V, Jones, A, Kennedy, G, Bell, J, Thomas, E L, Frost, G, Thomsen, H, Hansen, E, Hansen, T H, Vestergaard, H, Muilwijk, M, Blom, M T, ‘t Hart, L M, Hansen, T, Schwenk, J M, Adamski, J, McCarthy, M I, Pearson, E, Banasik, K, Rasmussen, S, Brunak, S & Franks, P W 2023, ' Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models ', Nature Biotechnology, vol. 41, no. 3, pp. 399-408 . https://doi.org/10.1038/s41587-022-01520-x
Nature Biotechnology, 41, 399-408. NATURE PORTFOLIO
Nature biotechnology, 41(3), 399-408. Nature Publishing Group

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes int

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