Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Eriko Okochi-Takada"'
Autor:
Eriko Okochi-Takada, Naoko Hattori, Akihiro Ito, Tohru Niwa, Mika Wakabayashi, Kana Kimura, Minoru Yoshida, Toshikazu Ushijima
Publikováno v:
Epigenetics, Vol 13, Iss 2, Pp 147-155 (2018)
Epigenetic alterations underlie various human disorders, including cancer, and this has resulted in the development of drugs targeting epigenetic alterations. Although DNA demethylating agents are one of the major epigenetic drugs, only two compounds
Externí odkaz:
https://doaj.org/article/be49087c12054f6d80d7887a316c5872
Autor:
B Keogh, M Najdovska, Masanobu Oshima, H Tye, Brendan J. Jenkins, Liang Yu, Alison C. West, S. J. Lin, William McCormack, Niantao Deng, Eriko Okochi-Takada, Jesse J. Balic, P McGuirk, Ke Tang, Toshikazu Ushijima, Prithi S. Bhathal, Puay Hoon Tan, M Reilly
Publikováno v:
Oncogene. 36:5134-5144
Toll-like receptors (TLRs) are key regulators of innate immune responses, and their dysregulation is observed in numerous inflammation-associated malignancies, including gastric cancer (GC). However, the identity of specific TLRs and their molecular
Autor:
Kenji Tamura, Yuki Kojima, Akihiro Hirakawa, Satoshi Yamashita, Toshikazu Ushijima, Akihiko Shimomura, Hitoshi Tsuda, Takayuki Kinoshita, Kan Yonemori, Yasuhiro Fujiwara, Eriko Okochi-Takada, Asuka Kawachi
Publikováno v:
Breast cancer research and treatment. 181(2)
A PARP inhibitor is effective in breast cancer patients with BRCA1/2 germline mutations, and in cell lines with BRCA1 promoter methylation. However, its efficacy in breast cancer patients with BRCA1 promoter methylation is still unknown. Biopsy sampl
Autor:
Kana Kimura, Naoko Hattori, Minoru Yoshida, Toshikazu Ushijima, Eriko Okochi-Takada, Tohru Niwa, Mika Wakabayashi, Akihiro Ito
Epigenetic alterations underlie various human disorders, including cancer, and this has resulted in the development of drugs targeting epigenetic alterations. Although DNA demethylating agents are one of the major epigenetic drugs, only two compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62d47dbb8b288be12e7de56b6c89748
https://europepmc.org/articles/PMC5873356/
https://europepmc.org/articles/PMC5873356/
Autor:
Satoshi Yamashita, Yutaka Saito, Ryoji Kushima, Eriko Okochi-Takada, Shigeki Sekine, Kiyoshi Asada, Hitoshi Katai, Hirokazu Taniguchi, Masayoshi Yamada, Takeshi Nakajima, Takeo Fukagawa, Ichiro Oda, Toshikazu Ushijima
Publikováno v:
Gastric Cancer. 17:750-756
Hereditary diffuse gastric cancer (HDGC), characterized by susceptibility to gastric signet ring cell carcinomas (SRCCs) and caused by CDH1 germline mutations, is rare in the Japanese. We present here a Japanese family with HDGC identified by compara
Autor:
Eriko Okochi-Takada, Tetsuya Tsukamoto, Naoko Hattori, S Ito, Kazuaki Miyamoto, Takayuki Ando, Toshikazu Ushijima, Yoshimasa Nobeyama, Yoshitaka Yamamura, Mika Wakabayashi
Publikováno v:
Oncogene. 33:2273-2278
Tumor suppressors with extracellular function are likely to have advantages as targets for cancer therapy, but few are known. Here, we focused on angiopoietin-like 4 (ANGPTL4), which is a secreted glycoprotein involved in lipoprotein metabolism and a
Autor:
Mika Wakabayashi, Takayuki Kinoshita, Toshikazu Ushijima, Mizuho Kikuyama, Sadako Akashi-Tanaka, Eriko Okochi-Takada, Hideyuki Takeshima, Yasuyuki Seto, Toshihisa Ogawa
Publikováno v:
Cancer Letters. 322:204-212
Identification of tumor-suppressor genes (TSGs) silenced by aberrant methylation of promoter CpG islands (CGIs) is important, but hampered by a large number of genes methylated as passengers of carcinogenesis. To overcome this issue, we here took adv
Autor:
Mika Wakabayashi, Toshikazu Ushijima, Satoshi Yamashita, Mizuho Kikuyama, Eriko Okochi-Takada, Naoko Hattori
Publikováno v:
Cancer Science. 102:1337-1343
Aberrant DNA methylation is deeply involved in the development and progression of human breast cancers, but its inducers and molecular mechanisms are still unclear. To reveal such inducers and clarify the molecular mechanisms, animal models are indis
Autor:
Eriko Okochi-Takada, Sadako Akashi-Tanaka, Kazuaki Miyamoto, Toshikazu Ushijima, Kotoe Terada, Hitoshi Tsuda, Michio Kaminishi, Kiyoshi Asada, Kiyomi Taniyama
Publikováno v:
Carcinogenesis. 30:466-471
The presence of frequent methylation of CpG islands (CGIs), designated as the CpG island methylator phenotype in some cancers, is associated with distinct clinicopathological characteristics, including gene amplification, in individual tumor types. A
Autor:
Hidemi Nakagawa, Junichi Furuta, Yukihiro Nakanishi, Akifumi Yamamoto, Kanako Kikuchi, Toshikazu Ushijima, Yoshimasa Nobeyama, Yohei Miyagi, Eriko Okochi-Takada
Publikováno v:
International Journal of Cancer. 121:301-307
To identify tumor-suppressor genes inactivated by aberrant methylation of promoter CpG islands (CGIs) in human malignant melanomas, genes upregulated by treatment of cells with a demethylating agent, 5-aza-2'-deoxycytidine (5-aza-dC), were searched f