Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Eriko Mano"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The intrinsic complexity of many mesoscale (10–100 nm) cellular machineries makes it challenging to elucidate their topological arrangement and transition dynamics. Here, we exploit DNA origami nanospring as a model system to demonstrate t
Externí odkaz:
https://doaj.org/article/3cb489dd24834dac981de3d6e889841e
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104292- (2022)
Summary: The DNA origami technique is used to construct custom-shaped nanostructures that can be used as components of two-dimensional crystalline structures with user-defined structural patterns. Here, we designed an Mg2+-responsive hexagonal 3D DNA
Externí odkaz:
https://doaj.org/article/54d0fe29a9944e0c97721e9916e51378
Autor:
Tracy T. Chuong, Toshihiko Ogura, Norihito Hiyoshi, Kazuma Takahashi, Sangho Lee, Keita Hiraga, Hiroki Iwase, Akira Yamaguchi, Kiyoto Kamagata, Eriko Mano, Satoshi Hamakawa, Hirotomo Nishihara, Takashi Kyotani, Galen D. Stucky, Tetsuji Itoh
Publikováno v:
ACS Applied Materials & Interfaces. 14:26507-26516
Cryogenic electron microscopy is one of the fastest and most robust methods for capturing high-resolution images of proteins, but stringent sample preparation, imaging conditions, and in situ radiation damage inflicted during data acquisition directl
Autor:
Ahmed Mostafa Abdelhady, Kazumitsu Onizuka, Kei Ishida, Sayaka Yajima, Eriko Mano, Fumi Nagatsugi
Publikováno v:
The Journal of Organic Chemistry. 87:2267-2276
Specific chemical reactions by enzymes acting on a nucleobase are realized by flipping the target base out of the helix. Similarly, artificial oligodeoxynucleotides (ODNs) can also induce the base flipping and a specific chemical reaction. We now rep
Autor:
Yuji Itoh, Sridhar Mandali, Cheng Tan, Reid C. Johnson, Yining Wu, Shoji Takada, Eriko Mano, Kiyoto Kamagata
Publikováno v:
Nucleic Acids Research
Nucleic acids research, vol 49, iss 15
Nucleic acids research, vol 49, iss 15
Architectural DNA-binding proteins (ADBPs) are abundant constituents of eukaryotic or bacterial chromosomes that bind DNA promiscuously and function in diverse DNA reactions. They generate large conformational changes in DNA upon binding yet can slid
Autor:
Satoshi Takahashi, Kana Ouchi, Yining Wu, Eriko Mano, Reid C. Johnson, Kiyoto Kamagata, Cheng Tan, Shoji Takada, Sridhar Mandali
Publikováno v:
Nucleic Acids Research
DNA binding proteins rapidly locate their specific DNA targets through a combination of 3D and 1D diffusion mechanisms, with the 1D search involving bidirectional sliding along DNA. However, even in nucleosome-free regions, chromosomes are highly dec
Publikováno v:
Organic Letters. 21:2833-2837
The base flip-inducing nucleic acids are expected to create a specific field for various chemical reactions. We now report a novel type of base-flip-inducing oligodeoxynucleotide and photo-cross-linking reaction. Two 3-arylethynyl-5-methyl-2-pyridone
Autor:
Agato Murata, Satoshi Takahashi, Eriko Mano, Kiyoto Kamagata, Chihiro Igarashi, Saori Kanbayashi, Yuji Itoh, Hiroto Takahashi
Publikováno v:
Biophysical Journal. 112:2301-2314
Tumor suppressor p53 slides along DNA and finds its target sequence in drastically different and changing cellular conditions. To elucidate how p53 maintains efficient target search at different concentrations of divalent cations such as Ca2+ and Mg2
Autor:
Hiroto Takahashi, Eriko Mano, Kiyoto Kamagata, Agato Murata, Yuji Itoh, Saori Kanbayashi, Takuro Wakamoto, Tomoshi Kameda, Ryo Kitahara
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Intrinsically disordered regions (IDRs) of proteins are involved in many diseases. The rational drug design against disease-mediating proteins is often based on the 3D structure; however, the flexible structure of IDRs hinders the use of such structu
Publikováno v:
Journal of molecular biology, vol 430, iss 5
J Mol Biol
J Mol Biol
Architectural DNA-binding proteins function to regulate diverse DNA reactions and have the defining property of significantly changing DNA conformation. Although the 1D movement along DNA by other types of DNA-binding proteins has been visualized, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2229455005f25014629ebea78400bc54
https://escholarship.org/uc/item/2sf502x6
https://escholarship.org/uc/item/2sf502x6