Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Eriko Koyama"'
1
Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans
Autor: Kunio Kakegawa, Osamu Izawa, Michio Ui, Eriko Koyama, Akiharu Fujino, Yuji Ohori, Norifumi Sakai, Ken Kitazawa
Publikováno v: Food and Chemical Toxicology. 41:875-883
Stevia mixture, sweeteners extracted from the leaves of Stevia rebaudiana Bertoni, consists mainly of the glycosides of the diterpene derivative steviol. The aims of this study were to investigate the absorption (in rats) and the hepatic metabolism (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa2986682474188c9214c883c4efbb6
https://doi.org/10.1016/s0278-6915(03)00039-5
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2
The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N- demethylation and 2-hydroxylation
Autor: M Hayashi, Eriko Koyama, A Saitoh, M Tani, Takashi Ishizaki, Kan Chiba
Publikováno v: British Journal of Clinical Pharmacology. 37:237-242
1. The metabolism of imipramine (N-demethylation and 2-hydroxylation) was studied in relation to the activity of S-mephenytoin 4'-hydroxylase in human liver microsomes. 2. Eadie-Hofstee plots for the formation of despiramine and 2-hydroxyimipramine w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6373061a02001c1c667e4b7306ede981
https://doi.org/10.1111/j.1365-2125.1994.tb04269.x
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3
Identification of the Human P450 Isoforms Involved in the Stereoselective Metabolism of Mianserin Enantiomers
Autor: Eriko Koyama, Masanao Tani, Noriaki Shimada, Kan Chiba, Takashi Ishizaki
Publikováno v: Drug Metabolism and Pharmacokinetics. 9:148-151
To identify cytochrome P450 isoform(s) involved in 8-hydroxylation, N-demethylation and N-oxidation of mianserin (US) enantiomers in humans, we studied the metabolism of S(+) and R(-)-MS using human liver microsomes and 6 different recombinant human
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2724eb2ce16b1b65b9dc532a6ba80736
https://doi.org/10.2133/dmpk.9.supplement_148
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4
Simultaneous High-Performance Liquid Chromatography-Electrochemical Detection Determination of Imipramine, Desipramine, Their 2-Hydroxylated Metabolites, and Imipramine N-Oxide in Human Plasma and Urine
Autor: Eriko Koyama, Takashi Ishizaki, Yumiko Kikuchi, Kan Chiba, Hirotoshi Echizen
Publikováno v: Therapeutic Drug Monitoring. 15:224-235
This assay method allows a simultaneous determination of imipramine, desipramine, their 2-hydroxylated metabolites, and imipramine-N-oxide in 0.5 ml of plasma or 0.1 ml of urine within 35 min by an ion-paired, reversed phase (C18) high-performance li
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a25248c002ca60806010b39e3fe91e7
https://doi.org/10.1097/00007691-199306000-00009
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5
Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy
Autor: Takahiro Kubota, Shigeru Morinobu, Takashi Ishizaki, Shiro Totsuka, Shinobu Kawakatsu, Takeshi Tanaka, Kan Chiba, Eriko Koyama
Publikováno v: Psychiatry and clinical neurosciences. 51(4)
The relationship between the genetic polymorphism of S-mephenytoin 4'-hydroxylation catalyzed by CYP2C19 and the N-demethylation of imipramine was examined in 10 Japanese depressed patients. Five patients, who were poor metabolizers of S-mephenytoin,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61531c88a015a94c00ee89535ccf6a88
https://pubmed.ncbi.nlm.nih.gov/9316174
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6
Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation
Autor: Kyoko Manabe, Takaaki Toyoki, Takashi Ishizaki, Yoshiro Tomono, Chiyuki Yamato, Masahiro Hayashi, Kan Chiba, Sanae Yasuda, Yukio Horai, Eriko Koyama
Publikováno v: Clinical pharmacology and therapeutics. 58(2)
Objective To compare the interaction potential of E3810, [(±)-sodium 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]-1H-benzimidazole] a new proton pump inhibitor, and omeprazole with diazepam in relation to S-mephenytoin 4′-hydroxyl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3605dbc171f524033c5bda29821cf6
https://pubmed.ncbi.nlm.nih.gov/7648765
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7
A random walk method for percutaneous drug absorption pharmacokinetics: application to repeated administration of a therapeutic timolol patch
Autor: Eriko Koyama, Kiyoshi Kubota, Kohtaro Yasuda
Publikováno v: Journal of pharmaceutical sciences. 80(8)
A random walk method for predicting percutaneous drug absorption pharmacokinetics was proposed. The profiles predicted by this method were compatible with those predicted by the analytical method. The random walk method is particularly useful for pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687ddf321b8170f8d80578cd448e952a
https://pubmed.ncbi.nlm.nih.gov/1791535
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