Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Eriko Isogai"'
Autor:
Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yoshimasa Aoto, Tsuyoshi Hachiya, Yasubumi Sakakibara, Yoshinori Katsuragi, Satoshi Hirose, Ryo Kominami, Ryo Goitsuka, Takuro Nakamura, Yuichi Wakabayashi
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102111 (2014)
Previous studies have shown that Meis1 plays an important role in blood development and vascular homeostasis, and can induce blood cancers, such as leukemia. However, its role in epithelia remains largely unknown. Here, we uncover two roles for Meis1
Externí odkaz:
https://doaj.org/article/1ee8ffa80179424789347212c892310d
Autor:
Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Ikuo Miura, Shigeharu Wakana, Ryo Kominami, Yuichi Wakabayashi
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97201 (2014)
Genome-wide association studies have revealed that many low-penetrance cancer susceptibility loci are located throughout the genome; however, a very limited number of genes have been identified so far. Using a forward genetics approach to map such lo
Externí odkaz:
https://doaj.org/article/ff5384b94a8949348963da849b1190d2
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19297 (2011)
Expression of Mash1 is dysregulated in human neuroblastoma. We have also reported that LMO3 (LIM-only protein 3) has an oncogenic potential in collaboration with neuronal transcription factor HEN2 in neuroblastoma. However, the precise molecular mech
Externí odkaz:
https://doaj.org/article/e19c513f158d4c4d83cfd118245ca30f
Publikováno v:
Biomedical Research. 43:91-97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc25bacff0d41894f9e4b137262033b1
https://doi.org/10.2220/biomedres.43.91
https://doi.org/10.2220/biomedres.43.91
Autor:
Naoko Kagawa, Eriko Isogai, Haruka Munakata, Megumi Saito, Yuichi Wakabayashi, Tatsuo Fukagawa, Kazuhiro Okumura
Publikováno v:
Cancer Science
CENP‐50/U is a component of the CENP‐O complex (CENP‐O/P/Q/R/U) and localizes to the centromere throughout the cell cycle. Aberrant expression of CENP‐50/U has been reported in many types of cancers. However, as Cenp‐50/U‐deficient mice d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffff765ae3d670242c4540450c72a12
https://doi.org/10.1111/cas.14533
https://doi.org/10.1111/cas.14533
Autor:
Eriko Isogai, Kazuhiro Okumura, Kimi Araki, Yasuhiro Yoshizawa, Yuichi Wakabayashi, Yuki Ito, Megumi Saito
Publikováno v:
Oncogene. 39:4756-4769
Pak1 (serine/threonine p21-activated kinases) was previously reported to have oncogenic activity in several cancers. However, its roles in the cancer microenvironment are poorly understood. We demonstrated that Pak1 expression in Langerhans cells (LC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6981aeab3d4e1571783191e04ba98c
https://doi.org/10.1038/s41388-020-1323-3
https://doi.org/10.1038/s41388-020-1323-3
Autor:
Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yurika Tokunaga, Yoshinori Hasegawa, Kimi Araki, Yuichi Wakabayashi
Publikováno v:
Journal of Investigative Dermatology. 142:2323-2333.e12
We identified a functional SNP in the 3' untranslated region of Pak1 that is responsible for the skin tumor modifier of MSM 1a locus. Candidate SNPs in the 3' untranslated region of Pak1 from resistance strain MSM/Ms were introduced into susceptible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367f7c1deb7271e03726f07e31451449
https://doi.org/10.1016/j.jid.2022.02.009
https://doi.org/10.1016/j.jid.2022.02.009
Autor:
Kazuhiro Okumura, Takehiko Kamijo, Koichi Matsuda, Ryo Kominami, Eriko Isogai, Kimi Araki, Megumi Saito, Yuichi Wakabayashi, Chizu Tanikawa
Publikováno v:
Journal of Investigative Dermatology. 139:1459-1469
Identification of the specific genetic variants responsible for the increased susceptibility to familial or sporadic cancers is important. Using a forward genetics approach to map such loci in a mouse skin cancer model, we previously identified a str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::468a6e45bbc8b3f913eadc0e269e4920
https://doi.org/10.1016/j.jid.2018.12.027
https://doi.org/10.1016/j.jid.2018.12.027
Publikováno v:
Cancers, Vol 13, Iss 1026, p 1026 (2021)
Cancers
Cancers
Simple Summary Since human studies on tumor susceptibility alleles require vast numbers of DNA samples from both cancer patients and well-matched controls, their investigation and identification in humans have been complemented using mouse models. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0730c58f0e5689c6d17b2bf990b19c2
https://pubmed.ncbi.nlm.nih.gov/33804471
https://pubmed.ncbi.nlm.nih.gov/33804471
Autor:
Midori Yamaguchi, Hiroshi Shitara, Kazuhiro Okumura, Ryo Kominami, Eriko Isogai, Yuichi Wakabayashi, Ikuo Miura, Megumi Saito, Andrew C. Karaplis, Choji Taya, Shigeharu Wakana, Haruka Munakata, Yasuhiro Yoshizawa
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Using a forward genetics approach to map loci in a mouse skin cancer model, we previously identified a genetic locus, Skin tumour modifier of MSM 1 (Stmm1) on chromosome 7, conferring strong tumour resistance. Sub-congenic mapping localized Parathyro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de8164d9b13ff5d9119cff5c36e62e0
http://link.springer.com/article/10.1038/s41598-017-11561-x
http://link.springer.com/article/10.1038/s41598-017-11561-x