Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Eriko, Matsuoka"'
Autor:
Naoya Asada, Tatsuhiko Ueno, Shiho Yamamoto, Ken-ichi Kusakabe, Diederik Moechars, Naoki Kanegawa, Harrie J.M. Gijsen, Frederik J. R. Rombouts, Mana Ito, Eriko Matsuoka, Hisanori Ito
Publikováno v:
Journal of Medicinal Chemistry. 64:14165-14174
β-Site amyloid precursor protein-cleaving enzyme 1 (BACE1) is considered to be a promising target for treating Alzheimer's disease. However, all clinical BACE1 inhibitors have failed due to lack of efficacy, and some have even led to cognitive worse
Autor:
Eriko Matsuoka, Hitomi Yamamoto
Publikováno v:
Transactions of Japan Society of Kansei Engineering. 19:281-289
Autor:
Yasuyoshi Iso, Shigeru Ando, Harrie J.M. Gijsen, Yasuto Kido, Shinji Suzuki, Herman Borghys, Kenji Morimoto, Vijay Urmaliya, Deborah Dhuyvetter, Takahiko Yamamoto, Ard Teisman, Gaku Sakaguchi, Naoki Kanegawa, Nigel Austin, Eriko Matsuoka, An Van Den Bergh, Hisanori Ito, Takuya Oguma, Francois Paul Bischoff, Tamio Fukushima, Peter Verboven, Tomoyuki Kawachi, Kenji Nakahara, Yoshinori Yamano, Kosuke Anan, Ken-ichi Kusakabe
Publikováno v:
ChemMedChem. 14:1894-1910
The β-site amyloid precursor protein cleaving enzyme 1 (BACE1, also known as β-secretase) is a promising target for the treatment of Alzheimer's disease. A pKa lowering approach over the initial leads was adopted to mitigate hERG inhibition and P-g
Autor:
Yoshiyuki, Taoda, Toshiyuki, Akiyama, Kenji, Tomita, Misato, Fujiwara-Kitamura, Yoshinori, Tamura, Takashi, Kawasuji, Eriko, Matsuoka, Erika, Akihisa, Takahiro, Seki, Tomokazu, Yoshinaga
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 64:128664
We have been conducting exploratory research to develop human immunodeficiency virus type-1 (HIV-1) integrase-LEDGF/p75 allosteric inhibitors (INLAIs). Here, we report on a newly designed compound with a tricyclic scaffold that shows promise as an in
Autor:
Kazuki Fujimoto, Shigeru Ando, Yutaka Tonomura, Shuhei Yoshida, Harrie J.M. Gijsen, Shiho Yamamoto, Diederik Moechars, Naoki Kanegawa, Frederik J. R. Rombouts, Hisanori Ito, Kouki Fuchino, Shinji Suzuki, Takahiko Yamamoto, Eriko Matsuoka, Genta Tadano, Naoya Asada, Ken-ichi Kusakabe
Publikováno v:
Journal of medicinal chemistry. 64(6)
BACE1 is an attractive target for disease-modifying treatment of Alzheimer's disease. BACE2, having high homology around the catalytic site, poses a critical challenge to identifying selective BACE1 inhibitors. Recent evidence indicated that BACE2 ha
Autor:
Tamura Yoshinori, Kenji Tomita, Tomokazu Yoshinaga, Shuhei Arita, Shuichi Sugiyama, Takahiro Seki, Tsutomu Iwaki, Eriko Matsuoka, Takashi Kawasuji
Publikováno v:
Bioorganicmedicinal chemistry. 28(17)
We report herein the discovery of novel integrase-LEDGF/p75 allosteric inhibitors (INLAIs) based on a benzene scaffold 3. This scaffold can extend substituents from the C1 position unlike the common pyridine scaffolds 2. Structure-activity relationsh
Autor:
Tatsuhiko Ueno, Eriko Matsuoka, Naoya Asada, Shiho Yamamoto, Naoki Kanegawa, Mana Ito, Hisanori Ito, Diederik Moechars, Rombouts, Frederik J. R., Gijsen, Harrie J. M., Ken-ichi Kusakabe
Publikováno v:
Journal of Medicinal Chemistry; 10/14/2021, Vol. 64 Issue 19, p14165-14174, 10p
Autor:
Yasuyoshi Iso, Naoki Kanegawa, Vijay Urmaliya, Kazuki Fujimoto, Kazuo Komano, Ard Teisman, An Van Den Bergh, Herman Borghys, Hisanori Ito, Shuhei Yoshida, Shigeru Ando, Yasuto Kido, Nigel E. Austin, Naoya Asada, Shinji Suzuki, Kenji Nakahara, Ken-ichi Kusakabe, Eriko Matsuoka, Harrie J.M. Gijsen, Gaku Sakaguchi, Genta Tadano, Yoshinori Yamano, Tamio Fukushima, Takahiko Yamamoto, Deborah Dhuyvetter, Kouki Fuchino
Publikováno v:
Journal of medicinal chemistry. 62(20)
Genetic evidence points to deposition of amyloid-β (Aβ) as a causal factor for Alzheimer's disease. Aβ generation is initiated when β-secretase (BACE1) cleaves the amyloid precursor protein. Starting with an oxazine lead 1, we describe the discov
Autor:
Kenji Nakahara, Harrie J.M. Gijsen, Naoki Kanegawa, Genta Tadano, Naoya Asada, Hisanori Ito, Takahiko Yamamoto, Diederik Moechars, Ken-ichi Kusakabe, Eriko Matsuoka, Kouki Fuchino, Kazuki Fujimoto
Publikováno v:
Journal of medicinal chemistry. 62(10)
BACE1 inhibitors hold potential as agents in disease-modifying treatment for Alzheimer's disease. BACE2 cleaves the melanocyte protein PMEL in pigment cells of the skin and eye, generating melanin pigments. This role of BACE2 implies that nonselectiv
Autor:
Takahiro Seki, Toshiyuki Akiyama, Yoshiyuki Taoda, Eriko Matsuoka, Tsutomu Iwaki, Takashi Kawasuji, Tomokazu Yoshinaga, Shuichi Sugiyama, Erika Akihisa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 33:127742
We have discovered HIV-1 novel integrase-LEDGF/p75 allosteric inhibitors (INLAIs) based on a pyridine scaffold forming an intramolecular hydrogen bond. Scaffolds containing a pyridine moiety have been studied extensively and we have already reported