Distinct proteomic profiles in prefrontal subareas of elderly major depressive disorder and bipolar disorder patients

Autor: Yang-Jian Qi, Yun-Rong Lu, Li-Gen Shi, Jeroen A. A. Demmers, Karel Bezstarosti, Erikjan Rijkers, Rawien Balesar, Dick Swaab, Ai-Min Bao

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract We investigated for the first time the proteomic profiles both in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) of major depressive disorder (MDD) and bipolar disorder (BD) patients. Cryostat sections of DLPF

Externí odkaz: https://doaj.org/article/35fd82e7a6684604b3dbe5d2b5cd1c76

Comparison of the PU.1 transcriptional regulome and interactome in human and mouse inflammatory dendritic cells

Autor: Vishal Salunkhe, Sjaak Philipsen, Rutger W W Brouwer, Timo K. van den Berg, Nynke Gillemans, Jeroen Demmers, Lianne van de Laar, Erikjan Rijkers, Wilfred F. J. van IJcken, Noemí Caballero-Sánchez, Iris M. De Cuyper, Pieter De Bleser, Maaike R. Scheenstra, Laura Gutierrez, Andrea Acebes-Huerta, Patricia Martínez-Botía, Benjamin Nota, Andrea M. Woltman, Taco W. Kuijpers

Publikováno v: RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Journal of leukocyte biology, 110(4), 735-751. FASEB
Journal of Leukocyte Biology, 1-17. John Wiley & Sons Inc.
STARTPAGE=1;ENDPAGE=17;ISSN=0741-5400;TITLE=Journal of Leukocyte Biology

Dendritic cells (DCs) are key immune modulators and are able to mount immune responses or tolerance. DC differentiation and activation imply a plethora of molecular and cellular responses, including transcriptional changes. PU.1 is a highly expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948526b0e9c69ecf828402662f0b66b5
http://hdl.handle.net/10651/57182

Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function

Autor: Erikjan Rijkers, Laura Gutierrez, Hans Janssen, Harmen J.G. van de Werken, Marjolein Meinders, Rutger W W Brouwer, Guntram Suske, Timo K. van den Berg, Sjaak Philipsen, Wilfred F. J. van IJcken, Mark Hoogenboezem, Imme Krüger, Jeroen Demmers, Divine I. Kulu

Publikováno v: Meinders, M, Kulu, D I, van de Werken, H J G, Hoogenboezem, M, Janssen, H, Brouwer, R W W, van Ijcken, W F J, Rijkers, E-J, Demmers, J A A, Krüger, I, van den Berg, T K, Suske, G, Gutiérrez, L & Philipsen, S 2015, ' Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function ', Blood, vol. 125, no. 12, pp. 1957-67 . https://doi.org/10.1182/blood-2014-08-593343
Blood, 125(12), 1957-67. American Society of Hematology
Blood, 125(12), 1957-1967. American Society of Hematology

Sp1 and Sp3 belong to the specificity proteins (Sp)/Krüppel-like transcription factor family. They are closely related, ubiquitously expressed, and recognize G-rich DNA motifs. They are thought to regulate generic processes such as cell-cycle and gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c85d0eab4bc6061f2c10f309f303862
https://doi.org/10.1182/blood-2014-08-593343

Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes

Autor: Jeroen Demmers, Shoumo Bhattacharya, Maaike J. Moen, Frank Grosveld, Sjaak Philipsen, Dick H. W. Dekkers, Wilfred F. J. van IJcken, Dorota Szumska, Robbert J. Rottier, Jan Christian Bryne, Erikjan Rijkers, Boris Lenhard, Larysa H. Pevny, Raymond A. Poot, Christel E M Kockx, Cristina Gontan, Jun Hou, Erik Engelen, Umut Akinci

Publikováno v: Nature Genetics, 43(6), 607-U153. Nature Publishing Group

The HMG-box transcription factor Sox2 plays a role throughout neurogenesis and also acts at other stages of development, as illustrated by the multiple organs affected in the anophthalmia syndrome caused by SOX2 mutations. Here we combined proteomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442e0f0621ef8b12d780b8575e00e140
https://doi.org/10.1038/ng.825

The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation

Autor: Christine Steinhoff, Mary Stevens, Erikjan Rijkers, Christel E M Kockx, Jan Christian Bryne, Jun Hou, Frank Grosveld, Boris Lenhard, Robert-Jan Palstra, Supat Thongjuea, Wilfred F. J. van IJcken, Ralph Stadhouders, Ernie de Boer, Eric Soler, Charlotte Andrieu-Soler

Publikováno v: Genes & Development, 24(6), 277-289. Cold Spring Harbor Laboratory Press
Genes & Development
Genes and Development, 24(6). Cold Spring Harbor Laboratory Press

One of the complexes formed by the hematopoietic transcription factor Gata1 is a complex with the Ldb1 (LIM domain-binding protein 1) and Tal1 proteins. It is known to be important for the development and differentiation of the erythroid cell lineage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebb0841211fbac140d33f02453990f5
https://pure.eur.nl/en/publications/0b350a53-cb25-4f03-b33d-1ed43a4cfbdd