Výsledky vyhledávání - "Erika Ziegler"

New Drug-Like Hydroxyphenylnaphthol Steroidomimetics As Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Estrogen-Dependent Diseases

Autor: Patricia Kruchten, Martin Frotscher, Claudia Henn, Sandrine Marchais-Oberwinkler, Marie Wetzel, Rolf W. Hartmann, Ruth Werth, Erika Ziegler

Publikováno v: Journal of Medicinal Chemistry. 54:534-547

Inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a novel and attractive approach to reduce the local levels of the active estrogen 17β-estradiol in patients with estrogen-dependent diseases like breast cancer or endometriosis. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a975ff6200cd5ef1d48847341a99f95b
https://doi.org/10.1021/jm1009082

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Development of biological assays for the identification of selective inhibitors of estradiol formation from estrone in rat liver preparations

Autor: Emmanuel Bey, Rolf W. Hartmann, Ruth Werth, Erika Ziegler, Martin Frotscher, Alexander Oster, Sandrine Marchais-Oberwinkler, Patricia Kruchten

Publikováno v: Comptes Rendus Chimie. 12:1110-1116

Estradiol (E2) is the most important estrogen in humans. Besides its physiological effects it is involved in the initiation and progression of estrogen dependent diseases like breast cancer and endometriosis. Common endocrine therapies have a strong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed0426a5ec033314572ebfd01138d3a1
https://doi.org/10.1016/j.crci.2009.05.005

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Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics

Autor: Josef Messinger, Alexander Neugebauer, Patricia Kruchten, Hubert Thole, Ursula Müller-Vieira, Sandrine Marchais-Oberwinkler, Martin Frotscher, Erika Ziegler, Umadevi Bhoga, Emmanuel Bey, Rolf W. Hartmann

Publikováno v: Journal of medicinal chemistry. 51(15)

17beta-Estradiol (E2) is implicated in the genesis and the development of estrogen-dependent diseases. Its concentration is mainly regulated by 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1), which catalyzes the reduction of the weak estrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a65a728b144e66937fe171808b444c1
https://pubmed.ncbi.nlm.nih.gov/18630892

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Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors

Autor: Ruth Werth, Sandrine Marchais-Oberwinkler, Erika Ziegler, Hubert Thole, Patricia Kruchten, Rolf W. Hartmann, Josef Messinger, Martin Frotscher

Publikováno v: Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2009, 301 (1-2), pp.205. ⟨10.1016/j.mce.2008.09.024⟩

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the transformation of estrone (E1) into the most potent estrogen, estradiol (E2), which stimulates cell proliferation and decreases apoptosis. 17β-HSD1 is often strongly overexpressed in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f252e7cba081988287564214fd21af
https://pubmed.ncbi.nlm.nih.gov/18950679

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Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases

Autor: Alexander Neugebauer, Sandrine Marchais-Oberwinkler, Ludivine Fetzer, Erika Ziegler, Josef Messinger, Martin Frotscher, Christiane Scherer, Ursula Müller-Vieira, Patricia Kruchten, Hubert Thole, Rolf W. Hartmann

Publikováno v: Journal of medicinal chemistry. 51(7)

Human 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) catalyzes the reduction of the weak estrogen estrone (E1) to the highly potent estradiol (E2). This reaction takes place in the target cell where the estrogenic effect is exerted via the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13645cdf19b73e8231f6d6f6788b11f1
https://pubmed.ncbi.nlm.nih.gov/18324762

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Akademický článek

New Drug-Like Hydroxyphenylnaphthol Steroidomimetics As Potent and Selective 17Î²-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Estrogen-Dependent Diseases.

Autor: Sandrine Marchais-Oberwinkler, Marie Wetzel, Erika Ziegler, Patricia Kruchten, Ruth Werth, Claudia Henn, Rolf W. Hartmann, Martin Frotscher

Publikováno v: Journal of Medicinal Chemistry; Jan2011, Vol. 54 Issue 2, p534-547, 14p

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Akademický článek

Substituted 6-Phenyl-2-naphthols. Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Design, Synthesis, Biological Evaluation, and Pharmacokinetics.

Autor: Sandrine Marchais-Oberwinkler, Patricia Kruchten, Martin Frotscher, Erika Ziegler, Alexander Neugebauer, Umadevi Bhoga, Emmanuel Bey, Ursula Müller-Vieira, Josef Messinger, Hubert Thole, Rolf W. Hartmann

Publikováno v: Journal of Medicinal Chemistry; Jul2008, Vol. 51 Issue 15, p4685-4698, 14p

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Akademický článek

Design, Synthesis, and Biological Evaluation of (Hydroxyphenyl)naphthalene and -quinoline Derivatives: Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) for the Treatment of...

Autor: Martin Frotscher, Erika Ziegler, Sandrine Marchais-Oberwinkler, Patricia Kruchten, Alexander Neugebauer, Ludivine Fetzer, Christiane Scherer, Ursula Müller-Vieira, Josef Messinger, Hubert Thole, Rolf W. Hartmann

Publikováno v: Journal of Medicinal Chemistry; Mar2008, Vol. 51 Issue 7, p2158-2169, 12p

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