Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Erika T. Hayes"'
Autor:
Julio Gomez-Rodriguez, Françoise Meylan, Robin Handon, Erika T. Hayes, Stacie M. Anderson, Martha R. Kirby, Richard M. Siegel, Pamela L. Schwartzberg
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
The Tec family tyrosine kinase, Itk, is a component of the T-cell receptor essential for optimal Th2 responses in vivo. Here the authors show in human cells and mouse models that Itk is also needed for the production of IL-9, an important contributor
Externí odkaz:
https://doaj.org/article/30020e049b654fe9a3907548fe25c55f
Publikováno v:
J Immunol
IL-2 is a critical regulator of immune homeostasis through its impact on both regulatory T (Treg) and effector T cells. However, the precise role of IL-2 in the maintenance and function of Treg cells in the adult peripheral immune system remains uncl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d8c15a81c5fa4aac37fb361114574c
https://doi.org/10.4049/jimmunol.1901520
https://doi.org/10.4049/jimmunol.1901520
Publikováno v:
The Journal of Experimental Medicine
The authors demonstrate that loss of ICOS-dependent PI3-kinase signaling supports visceral adipose tissue (VAT) TR abundance and function, and correlates with reduced adipose inflammation and improved insulin sensitivity after a high-fat diet. This h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfe4c2b8d0009059ee244dfbe0ac4b0
https://doi.org/10.1084/jem.20201142
https://doi.org/10.1084/jem.20201142
Interleukin-2 (IL-2) is a critical regulator of immune homeostasis through its impact on both regulatory T (Treg) and effector T (Teff) cells. However, the precise role of IL-2 in the maintenance and function of Treg cells in the adult peripheral imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79522334109bbb0d1c119da1a4f10d01
Autor:
Françoise Meylan, Julio Gomez-Rodriguez, Pamela L. Schwartzberg, Martha Kirby, Erika T. Hayes, Robin Handon, Richard M. Siegel, Stacie M. Anderson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Nature Communications
Nature Communications
Th9 cells produce interleukin (IL)-9, a cytokine implicated in allergic asthma and autoimmunity. Here we show that Itk, a mediator of T cell receptor signalling required for Th2 immune responses and the development of asthma, is a positive regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea5978743756c4ae2451e11e8f23703
https://doaj.org/article/30020e049b654fe9a3907548fe25c55f
https://doaj.org/article/30020e049b654fe9a3907548fe25c55f
Autor:
Erika T. Hayes, Odile Gabay, Françoise Meylan, Richard M. Siegel, Arianne C. Richard, John R. Ferdinand
Publikováno v:
Journal of Leukocyte Biology. 98:333-345
Originally described in 2002 as a T cell-costimulatory cytokine, the tumor necrosis factor family member TNF-like factor 1A (TL1A), encoded by the TNFSF15 gene, has since been found to affect multiple cell lineages through its receptor, death recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1c30224b5fbc351686c99065663ff8
https://doi.org/10.1189/jlb.3ri0315-095r
https://doi.org/10.1189/jlb.3ri0315-095r
Autor:
Anthony C. Cruz, Aymen Al-Shamkhani, Erika T. Hayes, Martin Pelletier, Matthew C. Walsh, Ritobrata Goswami, Arianne C. Richard, Odile Gabay, Eric T. Hawley, Richard M. Siegel, Françoise Meylan, Xiang-Ping Yang, Julio Gomez-Rodriguez, Igal Gery, Yongwon Choi, John R. Ferdinand, John J. O'Shea, Mark H. Kaplan, Pallavi Penumetcha, Cuiyan Tan, Andrea Keane-Myers
Publikováno v:
The Journal of Immunology. 194:3567-3582
The TNF family cytokine TL1A (Tnfsf15) costimulates T cells and type 2 innate lymphocytes (ILC2) through its receptor DR3 (Tnfrsf25). DR3-deficient mice have reduced T cell accumulation at the site of inflammation and reduced ILC2-dependent immune re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::169071ff46c68472d934ffd63d4aefc4
https://doi.org/10.4049/jimmunol.1401220
https://doi.org/10.4049/jimmunol.1401220
The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells
Autor:
Martin Pelletier, Richard M. Siegel, William E. Paul, Arianne C. Richard, Eric T. Hawley, Jillian L. Barlow, Thomas A. Wynn, Françoise Meylan, Erika T. Hayes, Giuseppe Sciumè, Luke Barron, Pallavi Penumetcha, Julio Gomez-Rodriguez, Xi Chen, Andrew N. J. McKenzie
Publikováno v:
Mucosal immunology
The tumor necrosis factor (TNF)-family cytokine TL1A (TNFSF15) costimulates T cells and promotes diverse T cell-dependent models of autoimmune disease through its receptor DR3. TL1A polymorphisms also confer susceptibility to inflammatory bowel disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1269852f02b2394dc9063f0260c3ccc
https://doi.org/10.1038/mi.2013.114
https://doi.org/10.1038/mi.2013.114
Autor:
Nathan Richoz, Hong-Wei Sun, Richard M. Siegel, Françoise Meylan, Kan Jiang, Chen Yao, Arian Laurence, Erika T. Hayes, Han-Yu Shih, Joshua D. Milner, Taylor K. Farley, Franziska Petermann, John J. O'Shea, Fred P. Davis, Yuan Zhang, Daniella M. Schwartz, Yohei Mikami, Yuka Kanno
Publikováno v:
Immunity. 50:106-120.e10
Summary CD4+ T helper (Th) differentiation is regulated by diverse inputs, including the vitamin A metabolite retinoic acid (RA). RA acts through its receptor RARα to repress transcription of inflammatory cytokines, but is also essential for Th-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a43d346f717d58411a9b82918e4580
https://doi.org/10.1016/j.immuni.2018.12.014
https://doi.org/10.1016/j.immuni.2018.12.014
Autor:
Arianne C. Richard, Cuiyan Tan, Eric T. Hawley, Julio Gomez-Rodriguez, Ritobrata Goswami, Xiang-Ping Yang, Anthony C. Cruz, Pallavi Penumetcha, Erika T. Hayes, Martin Pelletier, Odile Gabay, Matthew Walsh, John R. Ferdinand, Andrea Keane-Myers, Yongwon Choi, John J. O’Shea, Aymen Al-Shamkhani, Mark H. Kaplan, Igal Gery, Richard M. Siegel, FranÇoise Meylan
The TNF family cytokine TL1A (Tnfsf15) costimulates T cells and type 2 innate lymphocytes (ILC2) through its receptor DR3 (Tnfrsf25). DR3-deficient mice have reduced T cell accumulation at the site of inflammation and reduced ILC2-dependent immune re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90acb889779328305b49908c6d8baa2
https://europepmc.org/articles/PMC5584389/
https://europepmc.org/articles/PMC5584389/