Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Erika S Buechelmaier"'
Autor:
Manisha Jalan, Aman Sharma, Xin Pei, Nils Weinhold, Erika S. Buechelmaier, Yingjie Zhu, Sana Ahmed-Seghir, Abhirami Ratnakumar, Melody Di Bona, Niamh McDermott, Joan Gomez-Aguilar, Kyrie S. Anderson, Charlotte K. Y. Ng, Pier Selenica, Samuel F. Bakhoum, Jorge S. Reis-Filho, Nadeem Riaz, Simon N. Powell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Collisions of the transcription and replication machineries on the same DNA strand can pose a significant threat to genomic stability. These collisions occur in part due to the formation of RNA-DNA hybrids termed R-loops, in which a newly tr
Externí odkaz:
https://doaj.org/article/7cd61270c6534754a1bbd7203bce046c
Autor:
Aleksandra Vancevska, David Rueda, Simon N. Powell, Erika S. Buechelmaier, Matthew D. Newton, Ondrej Belan, Artur Kaczmarczyk, Simon J. Boulton, Roopesh Anand
DNA double strand breaks (DSBs) are deleterious lesions, and their incorrect repair can drive cancer development1. HELQ is a superfamily 2 helicase with 3’ to 5’ polarity, whose disruption in mice confers germ cells loss, infertility and increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99c6ea43e93065f18c0792c23777d0eb
https://doi.org/10.21203/rs.3.rs-583248/v1
https://doi.org/10.21203/rs.3.rs-583248/v1
Autor:
Jonathan E. Leeman, Manisha Jalan, Rama Rao Damerla, Edin Hamzic, Suleman S. Hussain, Daniel S. Higginson, Kyrie S. Anderson, Christopher Sifuentes, Pavithran T. Ravindran, Yi Li, Grace M. Moore, Neeman Mohibullah, Maximilian J Bazil, Rekha Soni, Rahul Majumdar, Simon N. Powell, Himanshi Narang, Erika S Buechelmaier, Andrea Farina, Agnes Viale, Xiaoqing Rong-Mullins
Publikováno v:
Nucleic Acids Research
Double strand break (DSB) repair primarily occurs through 3 pathways: non-homologous end-joining (NHEJ), alternative end-joining (Alt-EJ), and homologous recombination (HR). Typical methods to measure pathway usage include integrated cassette reporte
Autor:
Christopher Sifuentes, Andrea Farina, Grace M. Moore, Erika S. Buechelmaier, Jonathan E. Leeman, Rama Rao Damerla, Neeman Mohibullah, Kyrie S. Anderson, Rahul Majumdar, Daniel S. Higginson, Himanshi Narang, Agnes Viale, Pavithran T. Ravindran, Simon N. Powell, Rekha Soni, Manisha Jalan, Suleman S. Hussain, Yi Li, Edin Hamzic, Xiaoqing Rong-Mullins
Publikováno v:
SSRN Electronic Journal.
Double strand break (DSB) repair mainly occurs through 3 pathways: non-homologous end-joining (NHEJ), alternative end-joining (Alt-EJ), and homologous recombination (HR). We present an assay system that enables simultaneous measurement of all three p
Publikováno v:
Cancer cell. 35(3)
Tumors resistant to PARP inhibitors frequently show signs of replication stress, with hyper-activated PARP. In this issue of Cancer Cell, Pillay et al. demonstrate that inhibiting PAR-chain turnover results in cell-cycle arrest, which is cytotoxic wh
Publikováno v:
Molecular and Cellular Biology. 33:387-395
The Rad51 paralogs are required for homologous recombination (HR) and the maintenance of genomic stability. The molecular mechanisms by which the five vertebrate Rad51 paralogs regulate HR and genomic integrity remain unclear. The Rad51 paralogs asso