Adjunctive Immunotherapy With Polyclonal Ig-M Enriched Immunoglobulins for Septic Shock: From Bench to Bedside. The Rationale for a Personalized Treatment Protocol

Autor: Stefano Busani, Erika Roat, Martina Tosi, Emanuela Biagioni, Irene Coloretti, Marianna Meschiari, Roberta Gelmini, Lucio Brugioni, Sara De Biasi, Massimo Girardis

Publikováno v: Frontiers in Medicine, Vol 8 (2021)

Septic shock still has a high mortality rate which has not hinted at decreasing in recent years. Unfortunately, randomized trials failed mainly because the septic patient was considered as a homogeneous entity. All this creates a sort of therapeutic

Externí odkaz: https://doaj.org/article/ce56b847dafc4138808f3d31f39430ae

Adjunctive therapy with vitamin c and thiamine in patients treated with steroids for refractory septic shock: A propensity matched before-after, case-control study

Autor: Emanuela Biagioni, Massimo Girardis, Claudia Venturelli, Erika Roat, Elena Munari, Sophie Venturelli, Roberta Gelmini, Lucio Brugioni, Martina Tosi, Irene Coloretti

Publikováno v: Journal of Critical Care. 59:37-41

Purpose Triple therapy with steroids, vitamin C and thiamine has been recently proposed as a safe and beneficial in patients with sepsis. In 2017, we added the use of intravenous vitamin C and thiamine in septic shock patients receiving low dose hydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dda2dfc76ad503d7f4808e0c0065d2
https://doi.org/10.1016/j.jcrc.2020.04.014

Combination of low doses of Enzastaurin and Lenalidomide has synergistic activity in B-non-Hodgkin lymphoma cell lines

Autor: Maria Cosenza, Erika Roat, Alessia Bari, Monica Civallero, Stefano Sacchi, Luigi Marcheselli, Giulia Grisendi

Publikováno v: Annals of Hematology. 91:1613-1622

Less toxic and more active treatments are needed for indolent lymphomas as there is no curative treatment, and patients eventually die due to complications related to their disease. The purpose of the present study was to assess the antitumour activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319a01cf7fa8994a011961465bac690b
https://doi.org/10.1007/s00277-012-1490-6

Functional characterization of the promoter of the human Lon protease gene

Autor: Sara De Biasi, Milena Nasi, Erika Roat, Lara Gibellini, Marcello Pinti, José-Enrique O'Connor, Andrea Cossarizza

Publikováno v: MITOCHONDRION
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

Lon, a nuclear-encoded mitochondrial enzyme, degrades oxidized proteins of the mitochondrial (mt) matrix, and participates in the replication of mtDNA. Lon is upregulated in the presence of substances such as stavudine (d4T), D-deoxyribose (dRib), th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42a2a9a4a22bafe2cb5b4f1f99b2309
https://doi.org/10.1016/j.mito.2010.09.010

The Role of Mitochondria in HIV Infection and Its Treatment

Autor: Lara Gibellini, Andrea Cossarizza, Erika Roat, Milena Nasi, Linda Bertoncelli, Sara De Biasi, Marcello Pinti

Publikováno v: Journal of Experimental & Clinical Medicine. 2:145-155

Mitochondria play a dual role in the life of the cell, being capable of producing either energy (in the form of ATP) or potentially dangerous reactive oxygen species (ROS), and they also contain molecules that, when released into the cytoplasm, cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d474082cfb52a4f6dcb91e51339fabb
https://doi.org/10.1016/s1878-3317(10)60024-1