Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Erika P Hamilton"'
Autor:
Arvind Dasari, Erika P. Hamilton, Gerald S. Falchook, Judy S. Wang, Daneng Li, Max W. Sung, Caly Chien, Shivani Nanda, Christopher Tucci, Marjo Hahka-Kemppinen, Andrew Scott Paulson
Publikováno v:
Investigational New Drugs.
Surufatinib, is a potent inhibitor of vascular endothelial growth factor receptors 1–3; fibroblast growth factor receptor-1; colony-stimulating factor 1 receptor. This Phase 1/1b escalation/expansion study in US patients with solid tumors evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddcb9a02f4a998a162d10207c8e45627
https://doi.org/10.1007/s10637-023-01359-2
https://doi.org/10.1007/s10637-023-01359-2
Autor:
Karen A. Cadoo, David R. Spigel, Suzanne F. Jones, Juliann Chmielecki, Zhongwu Lai, Ganesh M. Mugundu, Sanjeev Kumar, Esteban Rodrigo Imedio, Janiel M. Cragun, Tiffany A. Troso-Sandoval, Jill J.J. Geenen, Daniel L. Spitz, Steven C. Plaxe, Gottfried E. Konecny, Sharad A. Ghamande, Amit M. Oza, Lee-may Chen, Erika P. Hamilton, Setsuko K. Chambers, Kathleen N. Moore
Supplementary tables S1-S3 and Supplementary figures S1-Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55af112ceb8321e8d2dd7167f8a42155
https://doi.org/10.1158/1078-0432.22484450.v1
https://doi.org/10.1158/1078-0432.22484450.v1
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Pharmacokinetic results at Day 29, by cohort (median [range])
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761803ef4b2434e7ff2418ba535f26e5
https://doi.org/10.1158/1078-0432.22469712
https://doi.org/10.1158/1078-0432.22469712
Autor:
Karen A. Cadoo, David R. Spigel, Suzanne F. Jones, Juliann Chmielecki, Zhongwu Lai, Ganesh M. Mugundu, Sanjeev Kumar, Esteban Rodrigo Imedio, Janiel M. Cragun, Tiffany A. Troso-Sandoval, Jill J.J. Geenen, Daniel L. Spitz, Steven C. Plaxe, Gottfried E. Konecny, Sharad A. Ghamande, Amit M. Oza, Lee-may Chen, Erika P. Hamilton, Setsuko K. Chambers, Kathleen N. Moore
Purpose:This study assessed the efficacy, safety, and pharmacokinetics of adavosertib in combination with four chemotherapy agents commonly used in patients with primary platinum-resistant ovarian cancer.Patients and Methods:Women with histologically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329c4cb04a3b96cf79664f7505b8f71f
https://doi.org/10.1158/1078-0432.c.6530816
https://doi.org/10.1158/1078-0432.c.6530816
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
LYC-55716 toxicology thermometer plot indicating a pharmacologically active exposure of 18.6μg·h/mL, based on the upregulation of target genes in mouse thymus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e54a85ba157ea25ab3981c8cf5782f9
https://doi.org/10.1158/1078-0432.22469721.v1
https://doi.org/10.1158/1078-0432.22469721.v1
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Baseline RORgt (RORC2) expression is variable from patient to patient.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a017a95fe20e70d01be7ff951de0f44d
https://doi.org/10.1158/1078-0432.22469715.v1
https://doi.org/10.1158/1078-0432.22469715.v1
Autor:
Seock-Ah Im, Hazel M. Weir, Gaia Schiavon, Shethah R. Morgan, Justin P.O. Lindemann, Teresa Klinowska, Matthias Hoch, Komal Jhaveri, Richard D. Baird, Anne C. Armstrong, Manish R. Patel, Erika P. Hamilton
PK parameters for M5 following a single dose (Day 1) and multiple doses (Day 15)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ced7bf7f2902d4c8a44515006033e93
https://doi.org/10.1158/1078-0432.22464378
https://doi.org/10.1158/1078-0432.22464378
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Purpose:Transcription factor retinoic acid receptor–related orphan receptor γ (RORγ) regulates type 17 effector T-cell differentiation and function and is key to immune cell regulation. Synthetic RORγ agonists modulate immune cell gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b94f77cf3892037b3e87257e1cdc429
https://doi.org/10.1158/1078-0432.c.6527316.v1
https://doi.org/10.1158/1078-0432.c.6527316.v1
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Post-treatment changes in IL-17A and pharmacokinetic profiles for Cohort 4a (600 mg QD) and Cohort 4b (300 mg BID). D, day; PD, pharmacodynamics; PK, pharmacokinetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f39aaacac1168b73f2c09557c63cdd5
https://doi.org/10.1158/1078-0432.22469718.v1
https://doi.org/10.1158/1078-0432.22469718.v1
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Fold induction over Day 1 pre-dose.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018d87e7dfac7d80c8c4c814cce840ab
https://doi.org/10.1158/1078-0432.22469709.v1
https://doi.org/10.1158/1078-0432.22469709.v1