A novel sampling design to explore gene-longevity associations: the ECHA study

Autor: James W. Vaupel, Emidio Feraco, Dina Bellizzi, Andrea Novelletto, Jean-Marie Robine, Giuseppina Rose, Giovanna De Benedictis, Luca Cavallone, Erika Marzi, Amandine Cournil, Jutta Gampe, Claudio Franceschi, Axel Skytthe, Bernard Jeune, Francesco De Rango, Giuseppe Passarino, Vincenzo Mari, Serena Dato

Publikováno v: De Rango, F, Dato, S, Bellizzi, D, Rose, G, Marzi, E, Cavallone, L, Franceschi, C, Skytthe, A, Jeune, B, Cournil, A, Robine, J M, Gampe, J, Vaupel, J W, Mari, V, Feraco, E, Passarino, G, Novelletto, A & De Benedictis, G 2008, ' A novel sampling design to explore gene-longevity associations : the ECHA study ', European Journal of Human Genetics, vol. 16, no. 2, pp. 236-242 . https://doi.org/10.1038/sj.ejhg.5201950

Udgivelsesdato: 2008-Feb To investigate the genetic contribution to familial similarity in longevity, we set up a novel experimental design where cousin-pairs born from siblings who were concordant or discordant for the longevity trait were analyzed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75577d560c6c13a6433758838793ce3f
https://doi.org/10.1038/sj.ejhg.5201950

The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians

Autor: Giuseppina, Carrieri, Erika, Marzi, Fabiola, Olivieri, Francesca, Marchegiani, Luca, Cavallone, Maurizio, Cardelli, Simona, Giovagnetti, Rosalia, Stecconi, Cinzia, Molendini, Chiara, Trapassi, Giovanna, De Benedictis, Dimitri, Kletsas, Claudio, Franceschi

Publikováno v: Aging cell. 3(6)

Sequence variations in a variety of pro- or anti-inflammatory cytokine genes have been found to influence successful aging and longevity. Because of the role played by the transforming growth factor beta1 (TGF-beta1) cytokine in inflammation and regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6c86a1b3b850a8a95e2e927e0f58a1f
https://pubmed.ncbi.nlm.nih.gov/15569360

Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients

Autor: Massimiliano, Bonafé, Claudio, Ceccarelli, Fulvia, Farabegoli, Donatella, Santini, Mario, Taffurelli, Cristiana, Barbi, Erika, Marzi, Chiara, Trapassi, Gianluca, Storci, Fabiola, Olivieri, Claudio, Franceschi

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 9(13)

The arginine to proline substitution at codon 72 represents a common aminoacidic polymorphism of the p53 protein. Recent data suggest that p53 codon 72 may modulate the response to cancer therapy. The aim of this study was to test the hypothesis that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::816d4cb4c80b3746f2e910d00b11ec33
https://pubmed.ncbi.nlm.nih.gov/14581358