Výsledky vyhledávání - "Erika Mancini"

Akademický článek

Patient-specific computational models predict prognosis in B cell lymphoma by quantifying pro-proliferative and anti-apoptotic signatures from genetic sequencing data

Autor: Richard Norris, John Jones, Erika Mancini, Timothy Chevassut, Fabio A. Simoes, Chris Pepper, Andrea Pepper, Simon Mitchell

Publikováno v: Blood Cancer Journal, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract Genetic heterogeneity and co-occurring driver mutations impact clinical outcomes in blood cancers, but predicting the emergent effect of co-occurring mutations that impact multiple complex and interacting signalling networks is challenging.

Externí odkaz: https://doaj.org/article/4991449ec30f4fbf973b0252325cc2f3

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PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions

Autor: Wilson, Rosemary H. C., Biasutto, Antonio J., Wang, Lihao, Fischer, Roman, Baple, Emma L., Crosby, Andrew H., Erika Mancini, Green, Catherine M.

Publikováno v: DNA Repair
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Highlights • We assess the cellular effects of the mutation that causes PARD (PCNAS228I). • Cells from affected individuals are sensitive to T2AA and T3. • PCNAS228I impairs interactions between PCNA and Cdt1, DNMT1, PolD3 and PolD4. • The PI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fd6d65ca7c9c6c0e000c60428cc95dd8
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