Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Erika M. Cook"'
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Akademický článek
CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering
Autor: Simone C. Oostindie, Hilma J. van der Horst, Margaret A. Lindorfer, Erika M. Cook, Jillian C. Tupitza, Clive S. Zent, Richard Burack, Karl R. VanDerMeid, Kristin Strumane, Martine E. D. Chamuleau, Tuna Mutis, Rob N. de Jong, Janine Schuurman, Esther C. W. Breij, Frank J. Beurskens, Paul W. H. I. Parren, Ronald P. Taylor
Publikováno v: Haematologica, Vol 104, Iss 9 (2019)
CD20 monoclonal antibody therapies have significantly improved the outlook for patients with B-cell malignancies. However, many patients acquire resistance, demonstrating the need for new and improved drugs. We previously demonstrated that the natura
Externí odkaz: https://doaj.org/article/8951ab20ead14f0a871191432d4962ce
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2
CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering
Autor: Margaret A. Lindorfer, Martine E.D. Chamuleau, Richard Burack, Paul W. H. I. Parren, Clive S. Zent, Ronald P. Taylor, Karl R. VanDerMeid, Tuna Mutis, Rob N. de Jong, Jillian C. Tupitza, Hilma J. van der Horst, Janine Schuurman, Erika M. Cook, Kristin Strumane, Frank J. Beurskens, Esther C.W. Breij, Simone C. Oostindie
Publikováno v: Haematologica
Haematologica, 104(9), 1841-1852. Ferrata Storti Foundation
Haematologica, 104(9), 1841-1852. FERRATA STORTI FOUNDATION
Oostindie, S C, Van Der Horst, H J, Lindorfer, M A, Cook, E M, Tupitza, J C, Zent, C S, Burack, R, VanDerMeid, K R, Strumane, K, Chamuleau, M E D, Mutis, T, De Jong, R N, Schuurman, J, Breij, E C W, Beurskens, F J, Parren, P W H I & Taylor, R P 2019, ' CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering ', Haematologica, vol. 104, no. 9, pp. 1841-1852 . https://doi.org/10.3324/haematol.2018.207266
CD20 monoclonal antibody therapies have significantly improved the outlook for patients with B-cell malignancies. However, many patients acquire resistance, demonstrating the need for new and improved drugs. We previously demonstrated that the natura
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43035da1f43e3f084bfdb3c5b9d915b0
https://hdl.handle.net/1887/121519
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3
Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions
Autor: Paul W. H. I. Parren, Ronald P. Taylor, Janine Schuurman, Erika M. Cook, Margaret A. Lindorfer, Clive S. Zent, Richard Burack, Hilma J. van der Horst, Frank J. Beurskens, Simone C. Oostindie
Publikováno v: The Journal of Immunology. 197:1762-1775
Recently, we demonstrated that IgG Abs can organize into ordered hexamers after binding their cognate Ags expressed on cell surfaces. This process is dependent on Fc:Fc interactions, which promote C1q binding, the first step in classical pathway comp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4aea215c39a8b6fb23938eae8437e8
https://doi.org/10.4049/jimmunol.1600648
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5
Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1
Autor: Adrian Wiestner, Xiuling Li, Haiyong Peng, Eman L. Dadashian, HaJeung Park, Junpeng Qi, Christoph Rader, Erika M. Cook
T cell-engaging bispecific antibodies (biAbs) present a promising strategy for cancer immunotherapy, and numerous bispecific formats have been developed for retargeting cytolytic T cells toward tumor cells. To explore the therapeutic utility of T cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee3a46623d68c5a9d4866806086d76c
https://europepmc.org/articles/PMC6004433/
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6
Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation
Autor: Burt G van der Boom, Patrick Van Berkel, Patrick J. Engelberts, Paul W. H. I. Parren, Ronald P. Taylor, Marleen Voorhorst, Margaret A. Lindorfer, Rob N. de Jong, Frank J. Beurskens, Ewald T. J. van den Bremer, Erika M. Cook
Publikováno v: mAbs
mAbs, 7(4), 672-680
van den Bremer, E T J, Beurskens, F J, Voorhorst, M, Engelberts, P J, de Jong, R N, van der Boom, B G, Cook, E M, Lindorfer, M A, Taylor, R P, van Berkel, P H C & Parren, P W H I 2015, ' Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation ', mAbs, vol. 7, no. 4, pp. 672-680 . https://doi.org/10.1080/19420862.2015.1046665
Human IgG is produced with C-terminal lysines that are cleaved off in circulation. The function of this modification was unknown and generally thought not to affect antibody function. We recently reported that efficient C1q binding and complement-dep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6e118b7ffe08a83e07dcf101455ebe
https://doi.org/10.1080/19420862.2015.1046665
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8
Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9
Autor: Masashi Mizuno, B. Paul Morgan, Frank J. Beurskens, Richard Burack, Paul W. H. I. Parren, Ronald P. Taylor, Erika M. Cook, Margaret A. Lindorfer, Karl R. VanDerMeid, Clive S. Zent, Janine Schuurman
Publikováno v: Clinical immunology (Orlando, Fla.). 181
We examined complement-dependent cytotoxicity (CDC) by hexamer formation-enhanced CD20 mAb Hx-7D8 of patient-derived chronic lymphocytic leukemia (CLL) cells that are relatively resistant to CDC. CDC was analyzed in normal human serum (NHS) and serum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e774fc00ddd51530766829b1cac917
https://pubmed.ncbi.nlm.nih.gov/28578024
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9
Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia
Autor: Edimara S. Reis, Margaret A. Lindorfer, Antonio M. Risitano, John D. Lambris, Ronald P. Taylor, Daniel Ricklin, Erika M. Cook
During malarial anemia, 20 uninfected red blood cells (RBCs) are destroyed for every RBC infected by Plasmodium falciparum (Pf). Increasing evidence indicates an important role for complement in destruction of uninfected RBCs. Products of RBC lysis i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f58e60bee88c7d1f1d4adc87d4825b
http://hdl.handle.net/11588/657182
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10
Validation of Clinical Prognostic Models and Integration of Genetic Biomarkers of Drug Resistance in CLL Patients Treated with Ibrutinib
Autor: Adrian Wiestner, James P. Dean, Wanlong Ma, Maher Albitar, L. Claire Tsao, Susan Soto, Inhye E. Ahn, Sarah E. M. Herman, Xin Tian, Erika M. Cook, Mei Cheng, David Ipe
Publikováno v: Blood. 132:186-186
Introduction: We previously reported a prognostic scoring system in CLL using pre-treatment factors in patients treated with ibrutinib [Ahn et al, 2016 ASH Annual Meeting]. Here we present long-term follow-up results and validation of the prognostic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8b570c765c613d610a4b10750eebc5f
https://doi.org/10.1182/blood-2018-99-110326
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