Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Erika M J, Siren"'
Publikováno v:
Cells, Vol 11, Iss 23, p 3854 (2022)
3-D cell cultures are being increasingly used as in vitro models are capable of better mimicry of in vivo tissues, particularly in drug screenings where mass transfer limitations can affect the cancer biology and response to drugs. Three-dimensional
Externí odkaz:
https://doaj.org/article/077b4d05e2c54c4e8f24e8c9eebc9c90
Autor:
Caigan Du, Haiming D. Luo, Megan K. Levings, Christine M. Wardell, Kevin Rey, Jayachandran N. Kizhakkedathu, Lyann Sim, Jonathan C. Choy, Qiunong Guan, Stephen G. Withers, Zheng J. Zhang, Franklin Tam, Mahdis Monajemi, Haisle Moon, Majid Mojibian, Ashani Montgomery, Erika M. J. Siren, Winnie Enns, Jiao Jing Wang
Publikováno v:
Nature Biomedical Engineering. 5:1202-1216
Systemic immunosuppression for the mitigation of immune rejection after organ transplantation causes adverse side effects and constrains the long-term benefits of the transplanted graft. Here we show that protecting the endothelial glycocalyx in vasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2175031ed608ed2b3119774c537262b
https://doi.org/10.1038/s41551-021-00777-y
https://doi.org/10.1038/s41551-021-00777-y
Autor:
Jayachandran N. Kizhakkedathu, Sargun Bajaj, Masoud Daneshi, D. Mark Martinez, Erika M. J. Siren, Edward M. Conway, Karen C. Cheung, Haiming D. Luo, Jordan MacKenzie
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(6)
The endothelial glycocalyx is a dynamic structure integral to blood vessel hemodynamics and capable of tightly regulating a range of biological processes (ie, innate immunity, inflammation, and coagulation) through dynamic changes in its composition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fcc1612d094929de82bb3dcdc5b844
https://pubmed.ncbi.nlm.nih.gov/33977574
https://pubmed.ncbi.nlm.nih.gov/33977574
Autor:
Deepak Bhere, Oren Levy, Nabeel Nissar, Erika M. J. Siren, Yuka Milton, Martina Heinelt, Mohanad Fallatah, Khalid Shah, Michael De Biasio, Abdulaziz Almalik, Brock Reeve, Jeffrey M. Karp, Ali H. Alhasan, Rui Kuai, Reza Abdi, Meshael Alturki
Publikováno v:
Science Advances
To realize the potential of MSCs, bioengineering is needed to boost potency and control heterogeneity.
More than 1050 clinical trials are registered at FDA.gov that explore multipotent mesenchymal stromal cells (MSCs) for nearly every clinical a
More than 1050 clinical trials are registered at FDA.gov that explore multipotent mesenchymal stromal cells (MSCs) for nearly every clinical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952dd1c97a2ff70ac47ccae7a7059a90
http://europepmc.org/articles/PMC7439491
http://europepmc.org/articles/PMC7439491
Autor:
Erika M J, Siren, Haiming D, Luo, Franklin, Tam, Ashani, Montgomery, Winnie, Enns, Haisle, Moon, Lyann, Sim, Kevin, Rey, Qiunong, Guan, Jiao-Jing, Wang, Christine M, Wardell, Mahdis, Monajemi, Majid, Mojibian, Megan K, Levings, Zheng J, Zhang, Caigan, Du, Stephen G, Withers, Jonathan C, Choy, Jayachandran N, Kizhakkedathu
Publikováno v:
Nature biomedical engineering. 5(10)
Systemic immunosuppression for the mitigation of immune rejection after organ transplantation causes adverse side effects and constrains the long-term benefits of the transplanted graft. Here we show that protecting the endothelial glycocalyx in vasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb072dc105ab07b80f5440822410952d
https://pubmed.ncbi.nlm.nih.gov/34373602
https://pubmed.ncbi.nlm.nih.gov/34373602
Fibre-reinforced biocompatible hydrogel to replace single-use plastic tubing in the clinical setting
Autor:
Erika M. J. Siren, Masoud Daneshi, Anthony Wachs, R. Melnick, T. Treskatis, Jordan MacKenzie, D.M. Martinez, Jayachandran N. Kizhakkedathu
Publikováno v:
Chemical Engineering Journal. 428:131786
In this work we examine a manufacturing process to produce hydrogel tubing for extracorporeal applications. In the first study we examine the methodology to scale-up extrusion printers to inertial flow conditions. We advance bounds to maintain hydrod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d859f1430179be69150a5635369a06af
https://doi.org/10.1016/j.cej.2021.131786
https://doi.org/10.1016/j.cej.2021.131786
Autor:
Donald E. Brooks, Jayachandran N. Kizhakkedathu, Erika M. J. Siren, Rafi Chapanian, Iren Constantinescu
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
Here we present a simple technique for re-directing reactions on the cell surface to the outermost region of the glycocalyx. Macromolecular crowding with inert polymers was utilized to reversibly alter the accessibility of glycocalyx proteoglycans to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36909371ba5adcfc4ea33952c809f674
http://link.springer.com/article/10.1038/s41598-018-25870-2
http://link.springer.com/article/10.1038/s41598-018-25870-2
Publikováno v:
ACS Biomaterials Science & Engineering. 4:3658-3677
The introduction of cell-based therapies has provided new and unique strategies to treat many diseases and disorders including the recent approval of CAR-T cell therapy for the leukemia. Cell surface engineering is a methodology in which the cell sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340b6fde0d8ca39d4bd2757178cc61a5
https://doi.org/10.1021/acsbiomaterials.7b00514
https://doi.org/10.1021/acsbiomaterials.7b00514
Autor:
Chunyi Zhao, Jeanne C. Y. Chan, Karen Y. T. Chan, Erika M. J. Siren, Christian J. Kastrup, Jeffrey Boschman
Publikováno v:
Biomacromolecules. 17:2248-2252
The adhesion of blood clots to blood vessels, such as through the adhesion of fibrin, is essential in hemostasis. While numerous strategies for initiating clot formation and preventing clot lysis are being developed to create improved hemostatic agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8d2d356978bf577985eb8d97b90f10
https://doi.org/10.1021/acs.biomac.6b00481
https://doi.org/10.1021/acs.biomac.6b00481
Autor:
Kai Yu, Robert E. W. Hancock, Erika M. J. Siren, Manu Thomas Kalathottukaren, Evan F. Haney, Yan Mei, Joey C. Y. Lo, Jayachandran N. Kizhakkedathu, Dirk Lange
Publikováno v:
ACS Applied Materials & Interfaces. 7:28591-28605
Bacterial infection associated with indwelling medical devices and implants is a major clinical issue, and the prevention or treatment of such infections is challenging. Antimicrobial coatings offer a significant step toward addressing this important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f315830808a19cd09f43ce0ba861b591
https://doi.org/10.1021/acsami.5b10074
https://doi.org/10.1021/acsami.5b10074