Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.

Autor: Andreas Billich, Thomas Baumruker, Christian Beerli, Marc Bigaud, Christian Bruns, Thomas Calzascia, Andrea Isken, Bernd Kinzel, Erika Loetscher, Barbara Metzler, Matthias Mueller, Barbara Nuesslein-Hildesheim, Bernadette Kleylein-Sohn

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59630 (2013)

BACKGROUND: Sphingosine-1-phosphate (S1P) regulates the egress of T cells from lymphoid organs; levels of S1P in the tissues are controlled by S1P lyase (Sgpl1). Hence, Sgpl1 offers a target to block T cell-dependent inflammatory processes. However,

Externí odkaz: https://doaj.org/article/07686167d0cf451ba24a1d1bcb253d4f

Functional expression of the serotonin 5-HT7receptor in human glioblastoma cell lines

Autor: Dominik Feuerbach, I. Bobirnac, Erika Loetscher, Michel Bernhard, Cécile Mahé, Corinna Keser, Philippe Schoeffter, Kumlesh K. Dev

Publikováno v: British Journal of Pharmacology. 143:404-410

Serotonin 5-HT(7) receptors are present in astrocytes. Understanding their role in this type of cell would greatly benefit from the identification of astroglial cell lines expressing this receptor type. The aim of the present study was to assess the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d62fd606195c98540a0e6e7275e10bf1
https://doi.org/10.1038/sj.bjp.0705936

Functional α2C-adrenoceptors in human neuroblastoma SH-SY5Y cells

Autor: Erika Loetscher, I. Bobirnac, Philippe Schoeffter, Lucien Gazi, Stephanie Parsley

Publikováno v: European Journal of Pharmacology. 372:109-115

The alpha2-adrenoceptor mediating inhibition of forskolin-stimulated cyclic AMP accumulation in human neuroblastoma SH-SY5Y cells was further characterized. The alpha2-adrenoceptor agonists, UK 14,304 (5-bromo-6-(2-imidazolin-2-ylamino)quinoxaline),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e447c2c95ccffc2369e681f497c8c90
https://doi.org/10.1016/s0014-2999(99)00190-9

Additional support for schizophrenia linkage on chromosomes 6 and 8: A multicenter study

Autor: Dieter B. Wildenauer, Sibylle G. Schwab, Margot Albus, Joachim Hallmayer, Bernard Lerer, Wolfgang Maier, Douglas Blackwood, Walter Muir, David St Clair, Stewart Morris, Hans W. Moises, Liu Yang, Helgi Kristbjarnarson, Tomas Helgason, Claudia Wiese, David A. Collier, Peter Holmans, Jo Daniels, Mark Rees, Philip Asherson, Queta Roberts, Alastair Cardno, Maria J. Arranz, Homero Vallada, David Ball, Hiroshi Kunugi, Robin M. Murray, John F. Powell, Sin Nanko, Pak Sham, Mike Gill, Peter McGuffin, Michael J. Owen, Ann E. Pulver, Stylianos E. Antonarakis, Robert Babb, Jean-Louis Blouin, Nicola DeMarchi, Beth Dombroski, David Housman, Maria Karayiorgou, Jurg Ott, Laura Kasch, Haig Kazazian, Virginia K. Lasseter, Erika Loetscher, Hermann Luebbert, Gerald Nestadt, Carl Ton, Paula S. Wolyniec, Claudine Laurent, Michel de Chaldee, Florence Thibaut, Maurice Jay, Daniele Samolyk, Michel Petit, Dominique Campion, Jacques Mallet, Richard E. Straub, Charles J. MacLean, Stephen M. Easter, F. Anthony O'Neill, Dermot Walsh, Kenneth S. Kendler, Pablo V. Gejman, Qiuhe Cao, Elliot Gershon, Judith Badner, Ethiopia Beshah, Jing Zhang, Brien P. Riley, Swarnageetha Rajagopalan, Mpala Mogudi-Carter, Trefor Jenkins, Robert Williamson, Lynn E. DeLisi, Chad Garner, Mary Kelly, Carrie LeDuc, Lon Cardon, Jay Lichter, Tim Harris, Josephine Loftus, Gail Shields, Margarite Comasi, Antonio Vita, Angela Smith, Jay Dann, Geoff Joslyn, Hugh Gurling, Gursharan Kalsi, Jon Brynjolfsson, David Curtis, Thordur Sigmundsson, Robert Butler, Tim Read, Patrice Murphy, Andrew Chih-Hui Chen, Hannes Petursson, Bill Byerley, Mark Hoff, John Holik, Hilary Coon, Douglas F. Levinson, Derek J. Nancarrow, Raymond R. Crowe, Nancy Andreasen, Jeremy M. Silverman, Richard C. Mohs, Larry J. Siever, Jean Endicott, Lawrence Sharpe, Marilyn K. Walters, David P. Lennon, Nicholas K. Hayward, Lodewijk A. Sandkuijl, Bryan J. Mowry, Harald N. Aschauer, Kurt Meszaros, Elisabeth Lenzinger, Karoline Fuchs, Angela M. Heiden, Leonid Kruglyak, Mark J. Daly, Tara C. Matise

Publikováno v: American Journal of Medical Genetics. 67:580-594

In response to reported schizophrenia linkage findings on chromosomes 3, 6 and 8, fourteen research groups genotyped 14 microsatellite markers in an unbiased, collaborative (New) sample of 403-567 informative pedigrees per marker, and in the Original

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eed6167e4522c861b0fa99357177409
https://doi.org/10.1002/(sici)1096-8628(19961122)67:6<580::aid-ajmg11>3.0.co

Comparative pharmacology of the human NMDA-receptor subtypes R1-2A, R1-2B, R1-2C and R1-2D using an inducible expression system

Autor: Stephanie Neurdin, Dominik Feuerbach, Manuel Koller, Erika Loetscher

Publikováno v: European journal of pharmacology. 637(1-3)

Pharmacological characterization of N-methyl-D-aspartate (NMDA) receptors has been hampered by the difficulty to outwit cytotoxicity after functional expression in recombinant systems. In this study a muristerone-inducible expression system for the N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b036975f04dc56cfac95b9ee76d48910
https://pubmed.ncbi.nlm.nih.gov/20394742