Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Erika L. Manyak"'
Autor:
Kristy Kuplast-Barr, Melissa L. Johnson, Manish R. Patel, Timothy A. Yap, Gerald S. Falchook, Patricia LoRusso, Ryan Abo, Chang Liu, Erika L. Manyak, Lisa Cleary, Viviana Bozon, Sudha Parasuraman, Heike Keilhack, Kristen McEachern
Publikováno v:
Cancer Research. 82:1836-1836
Background: PARP7 is a mono-ART that is upregulated in response to cellular stress (e.g., viral infection, cigarette smoke), and suppresses the Type I interferon (IFN) response following cytosolic nucleic acid sensing. RBN-2397 is a first-in-class PA
Autor:
Li Sha, Kerry E. Murphy-Benenato, Frank Wu, Thomas F. Durand-Reville, Haris Jahic, Hajnalka E. Davis, Ning Gao, Mark Sylvester, Shannon X. Zhao, Olga Quiroga, Erika L. Manyak, Michael T. Rooney, John P. Mueller, Brian Dangel, Andrew D. Ferguson, Mark Zambrowski
A main challenge in the development of new agents for the treatment of Pseudomonas aeruginosa infections is the identification of chemotypes that efficiently penetrate the cell envelope and are not susceptible to established resistance mechanisms. Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250216b54c9993a14170a724d0151038
https://europepmc.org/articles/PMC4434466/
https://europepmc.org/articles/PMC4434466/
Autor:
David E. Ehmann, Mark Zambrowski, Adam B. Shapiro, Pratik R. Bhagunde, Beesan Tan, Kerry E. Murphy-Benenato, Li Sha, Olga Quiroga, Vincent Galullo, Hajnalka E. Davis, M. R. Manjunatha, Holia Hatoum-Mokdad, Mark Sylvester, Aryun Kim, Haris Jahic, Shannon X. Zhao, Ye Wu, April Chen, Andy S. Tsai, Jennifer J. Harris, Sara A. Patey, Michael T. Rooney, Erika L. Manyak, Thomas F. Durand-Reville, Maria Uria-Nickelsen, John P. Mueller
Publikováno v:
Journal of medicinal chemistry. 58(5)
To identify new agents for the treatment of multi-drug-resistant Pseudomonas aeruginosa, we focused on siderophore-conjugated monocarbams. This class of monocyclic β-lactams are stable to metallo-β-lactamases and have excellent P. aeruginosa activi