Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Erika L D Mitchell"'
Case of extra pulmonary, pleuro-pulmonary blastoma in a child: Pathological and cytogenetic findings
Publikováno v:
Medical and Pediatric Oncology. 29:61-64
We report the cytogenetic findings in a case of Pleuro-Pulmonary Blastoma of Childhood Type II. This is a rare intrathoracic tumour that can occur in the lungs with up to 25% of cases being extra pulmonary.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::162be8d90ca85132106cda47f5c39ad4
https://doi.org/10.1002/(sici)1096-911x(199707)29:1<61::aid-mpo11>3.0.co
https://doi.org/10.1002/(sici)1096-911x(199707)29:1<61::aid-mpo11>3.0.co
Autor:
Gavin R M White, Daniel S. Liscia, Graham Casey, Maria Stack, Tiziania Venesio, David Jones, David Crichton, Erika L D Mitchell, Jenny Varley, Mauro Santibanez-Koref, Jim Heighway
Publikováno v:
Human Molecular Genetics. 4:2047-2055
The chromosome region 17p13.3 is thought to encode a tumour suppressor gene involved in sporadic breast cancer and other malignancies. Physical ordering of markers has been carried out by a series of multicolour fluorescent in situ hybridisation (FIS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b66c5f4dd1961c4271beed48cba7d8f
https://doi.org/10.1093/hmg/4.11.2047
https://doi.org/10.1093/hmg/4.11.2047
Autor:
David Jones, Jennifer Varley, Louise A James, Nigel Hoggard, Bill Brintnell, Erika L D Mitchell, Yvonne Hey, J Weissenbach
Publikováno v:
Genomics. 30:233-243
We have mapped a region of high loss of heterozygosity in breast cancer to a 2-cM interval between the loci D1S430 and D1S465 on chromosome 1p31.1. This region shows allelic imbalance in around 60% of breast tumors. As part of a strategy to clone the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165a746de0ec94cecd7c5ff59c7dbd2e
https://doi.org/10.1006/geno.1995.9882
https://doi.org/10.1006/geno.1995.9882
Publikováno v:
Gene. 151:309-314
The helix-loop-helix (HLH) family of transcription factors plays a central role in the regulation of cell growth, differentiation and tumourigenesis. Members of the Id (inhibitor of DNA binding) class of these nuclear proteins are able to heterodimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4dc17d19f1066757519f2a110d7ce5
https://doi.org/10.1016/0378-1119(94)90676-9
https://doi.org/10.1016/0378-1119(94)90676-9
Publikováno v:
Genes, Chromosomes and Cancer. 4:89-91
We report here the presence of ring chromosomes in a retroperitoneal lipoma from a 12-year-old male. Ring chromosomes are strongly associated with the pathological subtype "atypical lipoma" in adults. In contrast, however, the tumour described here p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4394396a4ddb8f6920f80f4d753504
https://doi.org/10.1002/gcc.2870040114
https://doi.org/10.1002/gcc.2870040114
Autor:
Jennifer Varley, John M Boyle, Stephen A Roberts, E C Burt, Martin J Greaves, Erika L D Mitchell, K. Tricker, Jillian M Birch, David Scott
Publikováno v:
British Journal of Cancer
Previous work has indicated a role for p53 in cell cycle control, genomic stability and cellular responses to DNA-damaging agents. However, few data are available for human fibroblasts heterozygous for defined germline mutations in TP53. We report st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74bc456c3223f8237c122d27e2e6358f
https://pubmed.ncbi.nlm.nih.gov/9649131
https://pubmed.ncbi.nlm.nih.gov/9649131
Publikováno v:
Oncogene. 14(9)
Comparative genomic hybridisation has been used to map copy number changes in nine cases of ductal carcinoma in situ of the breast obtained from wax-embedded archive material. A wide variety of abnormalities were detected including gain of regions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e94f09f32ab8b45a24edb5233570905
https://pubmed.ncbi.nlm.nih.gov/9070654
https://pubmed.ncbi.nlm.nih.gov/9070654
Publikováno v:
Pediatric hematology and oncology. 13(5)
We report here the cytogenetic analysis of a neuroblastoma from a 6-month-old male. Both conventional GTG banded analysis and fluorescence in situ hybridization were performed. The tumour was found to have a der(17)t(1;17)(p34;q21).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0111a394c263fbd231a4391f0c92b3
https://pubmed.ncbi.nlm.nih.gov/10897818
https://pubmed.ncbi.nlm.nih.gov/10897818
Publikováno v:
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 3(4)
The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6313e880e1daa210d3f8e689078452
https://pubmed.ncbi.nlm.nih.gov/7606365
https://pubmed.ncbi.nlm.nih.gov/7606365
Autor:
David Jones, Gavin R M White, Jim Heighway, Mauro F. Santibfifiez Koref, Erika L. D. Mitchell
Publikováno v:
Human Genetics. 93
An NlaIV polymorphism in the 5' untranslated region of the MDM2 gene is described. MDM2 was sublocalised by fluorescence in situ hybridisation with a yeast artificial chromosome probe to 12q14.3-12q15. We demonstrate the use of the polymorphism to as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb41ad1e6fa02753f61750871be960f
https://doi.org/10.1007/bf00202837
https://doi.org/10.1007/bf00202837