Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Erika L, Pearce"'
Autor:
Matteo Villa, David E. Sanin, Petya Apostolova, Mauro Corrado, Agnieszka M. Kabat, Carmine Cristinzio, Annamaria Regina, Gustavo E. Carrizo, Nisha Rana, Michal A. Stanczak, Francesc Baixauli, Katarzyna M. Grzes, Jovana Cupovic, Francesca Solagna, Alexandra Hackl, Anna-Maria Globig, Fabian Hässler, Daniel J. Puleston, Beth Kelly, Nina Cabezas-Wallscheid, Peter Hasselblatt, Bertram Bengsch, Robert Zeiser, Sagar, Joerg M. Buescher, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immune cells must adapt to different environments during the course of an immune response. Here we study the adaptation of CD8+ T cells to the intestinal microenvironment and how this process shapes the establishment of the CD8+ T cell pool.
Externí odkaz:
https://doaj.org/article/94dc27161c6a48b2b42944d1f1be38af
Autor:
Angela Castoldi, David E. Sanin, Nikki van Teijlingen Bakker, Cristhiane F. Aguiar, Lauar de Brito Monteiro, Nisha Rana, Katarzyna M. Grzes, Agnieszka M. Kabat, Jonathan Curtis, Alanna M. Cameron, George Caputa, Tiago Antônio de Souza, Fabrício O. Souto, Joerg M. Buescher, Joy Edwards-Hicks, Erika L. Pearce, Edward J. Pearce, Niels Olsen Saraiva Camara
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107719- (2023)
Summary: Little is known about the effects of high-fat diet (HFD)-induced obesity on resident colonic lamina propria (LP) macrophages (LPMs) function and metabolism. Here, we report that obesity and diabetes resulted in increased macrophage infiltrat
Externí odkaz:
https://doaj.org/article/70708d6c2e6b42e9aa409bf406d9bad6
Autor:
Trishan Vaikunthanathan, Emmanuelle Landmann, Diana Marin Correa, Marco Romano, Silvia Cellone Trevelin, Qi Peng, Elena Crespo, Mauro Corrado, Juan-José Lozano, Erika L. Pearce, Elena Perpinan, Anna Zoccarato, Leonard Siew, Joy Edwards-Hicks, Reenam Khan, Nguyet-Thin Luu, Mark R. Thursz, Philip N. Newsome, Marc Martinez-Llordella, Naina Shah, Robert I. Lechler, Ajay M. Shah, Alberto Sanchez-Fueyo, Giovanna Lombardi, Niloufar Safinia
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104778- (2023)
Summary: Background: Dysregulated inflammatory responses and oxidative stress are key pathogenic drivers of chronic inflammatory diseases such as liver cirrhosis (LC). Regulatory T cells (Tregs) are essential to prevent excessive immune activation an
Externí odkaz:
https://doaj.org/article/2057022316c44f44b2bce7e9345fbc6f
Autor:
Joy Edwards-Hicks, Huizhong Su, Maurizio Mangolini, Kubra K. Yoneten, Jimi Wills, Giovanny Rodriguez-Blanco, Christine Young, Kevin Cho, Heather Barker, Morwenna Muir, Ania Naila Guerrieri, Xue-Feng Li, Rachel White, Piotr Manasterski, Elena Mandrou, Karen Wills, Jingyu Chen, Emily Abraham, Kianoosh Sateri, Bin-Zhi Qian, Peter Bankhead, Mark Arends, Noor Gammoh, Alex von Kriegsheim, Gary J. Patti, Andrew H. Sims, Juan Carlos Acosta, Valerie Brunton, Kamil R. Kranc, Maria Christophorou, Erika L. Pearce, Ingo Ringshausen, Andrew J. Finch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
MYC activation can sensitise cells to apoptosis upon glutamine withdrawal. Here the authors show that MYC activation enhances global transcription and translation that creates a metabolic demand, while glutamine limitation causes a metabolic demand a
Externí odkaz:
https://doaj.org/article/f58e694b2f6c429fb6bed6c1ae69a6f7
Autor:
Michal A. Stanczak, David E. Sanin, Petya Apostolova, Gabriele Nerz, Dimitrios Lampaki, Maike Hofmann, Daniel Steinmann, Marvin Krohn-Grimberghe, Robert Thimme, Gerhard Mittler, Cornelius F. Waller, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Our understanding of the immune response to SARS-CoV-2 infection is still incomplete. Here, the authors find that IL-33, produced during immune recall potentially by CD14+ monocytes, correlates with CD4+ T cell activation, anti-SARS-CoV-2 antibody ti
Externí odkaz:
https://doaj.org/article/89933778592e495dada140299ff2f8c5
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract MZB1 is an endoplasmic reticulum (ER)-resident protein that plays an important role in the humoral immune response by enhancing the interaction of the μ immunoglobulin (Ig) heavy chain with the chaperone GRP94 and by augmenting the secretio
Externí odkaz:
https://doaj.org/article/972697e64b8a4a0083614fad217f537c
Autor:
Angela Castoldi, Lauar B. Monteiro, Nikki van Teijlingen Bakker, David E. Sanin, Nisha Rana, Mauro Corrado, Alanna M. Cameron, Fabian Hässler, Mai Matsushita, George Caputa, Ramon I. Klein Geltink, Jörg Büscher, Joy Edwards-Hicks, Erika L. Pearce, Edward J. Pearce
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
As macrophages switch to a proinflammatory gylcolytic state they start to generate triglyceride-rich lipid droplets, but what function these droplets have in this context is not clear. Here the authors show that this triglyceride synthesis is requisi
Externí odkaz:
https://doaj.org/article/e66368483cc344ee9854c2ede5bf41d5
Autor:
Mauro Corrado, Erika L. Pearce
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
Vaccination affords protection from disease by activating pathogen-specific immune cells and facilitating the development of persistent immunologic memory toward the vaccine-specific pathogen. Current vaccine regimens are often based on the efficienc
Externí odkaz:
https://doaj.org/article/9ca1f4d148a145d0a583624e06f4ba70
Publikováno v:
Immunity. 56:723-741
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd574f67541d54e7a06167e9e58cac02
https://doi.org/10.1016/j.immuni.2023.03.007
https://doi.org/10.1016/j.immuni.2023.03.007
Autor:
Stefanie Scherer, Susanne G. Oberle, Kristiyan Kanev, Ann-Katrin Gerullis, Ming Wu, Gustavo P. de Almeida, Daniel J. Puleston, Francesc Baixauli, Lilian Aly, Alessandro Greco, Tamar Nizharadze, Nils B. Becker, Madlaina v. Hoesslin, Lara V. Donhauser, Jacqueline Berner, Talyn Chu, Hayley A. McNamara, Zeynep Esencan, Patrick Roelli, Christine Wurmser, Ingo Kleiter, Maria J. G. T. Vehreschild, Christoph A. Mayer, Percy Knolle, Martin Klingenspor, Valeria Fumagalli, Matteo Iannacone, Martin Prlic, Thomas Korn, Erika L. Pearce, Thomas Höfer, Anna M. Schulz, Dietmar Zehn
Publikováno v:
Nature Immunology
Blocking pyrimidine de novo synthesis by inhibiting dihydroorotate dehydrogenase is used to treat autoimmunity and prevent expansion of rapidly dividing cell populations including activated T cells. Here we show memory T cell precursors are resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085f2909a004801c889c7b71682d6c58
https://doi.org/10.1038/s41590-023-01436-x
https://doi.org/10.1038/s41590-023-01436-x