Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Erika Kapp"'
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100211- (2024)
This study presents a series of coumarin nitric oxide donor hybrids that were synthesized, and characterized using FT-IR, H NMR, C NMR, and HR-MS techniques. Initial screening for anti-tubercular activity was conducted against Mycolicibacterium smegm
Externí odkaz:
https://doaj.org/article/d7410d0bff874538b61d6dc8f137ddd5
Autor:
Erika Kapp, Jacques Joubert, Samantha L. Sampson, Digby F. Warner, Ronnett Seldon, Audrey Jordaan, Margaretha de Vos, Rajan Sharma, Sarel F. Malan
Publikováno v:
Advances in Pharmacological and Pharmaceutical Sciences, Vol 2021 (2021)
Mycobacterium tuberculosis has developed extensive resistance to numerous antimycobacterial agents used in the treatment of tuberculosis. Insufficient intracellular accumulation of active moieties allows for selective survival of mycobacteria with dr
Externí odkaz:
https://doaj.org/article/88c1c1f46efe44879b93b4033a581dc2
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207605 (2018)
Mycobacterial efflux pumps play a major role in the emergence of antimycobacterial drug resistance. Of particular interest is the proteinaceous multi-drug efflux pump protein Rv1258c that encodes a tetracycline/aminoglycoside resistance (TAP-2)-like
Externí odkaz:
https://doaj.org/article/376cd44112cc4bb49fa7f02bcedbced8
Autor:
Erika Kapp, Hanri Visser, Samantha L. Sampson, Sarel F. Malan, Elizabeth M. Streicher, Germaine B. Foka, Digby F. Warner, Sylvester I. Omoruyi, Adaze B. Enogieru, Okobi E. Ekpo, Frank T. Zindo, Jacques Joubert
Publikováno v:
Molecules, Vol 22, Iss 10, p 1644 (2017)
A medium-throughput screen using Mycobacterium tuberculosis H37Rv was employed to screen an in-house library of structurally diverse compounds for antimycobacterial activity. In this initial screen, eleven 7-substituted coumarin derivatives with conf
Externí odkaz:
https://doaj.org/article/40c80158149344729d27ffcd8ef7f00a
Autor:
Erika Kapp, Hanri Calitz, Elizabeth M. Streicher, Anzaan Dippenaar, Samuel Egieyeh, Audrey Jordaan, Digby F. Warner, Jacques Joubert, Sarel F. Malan, Samantha L. Sampson
Publikováno v:
Tuberculosis. 141:102350
Autor:
Rajan Sharma, Erika Kapp, Sarel F. Malan, Digby F. Warner, Ronnett Seldon, Margaretha de Vos, Samantha L. Sampson, Jacques Joubert, Audrey Jordaan
Publikováno v:
Advances in Pharmacological and Pharmaceutical Sciences, Vol 2021 (2021)
Advances in Pharmacological and Pharmaceutical Sciences
Advances in Pharmacological and Pharmaceutical Sciences
Mycobacterium tuberculosis has developed extensive resistance to numerous antimycobacterial agents used in the treatment of tuberculosis. Insufficient intracellular accumulation of active moieties allows for selective survival of mycobacteria with dr
Autor:
Jacques Joubert, Erika Kapp
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(9)
Butyrylcholinesterase (BuChE) is considered a promising drug target as it plays an important role in the progression of late stage Alzheimer’s disease (AD). Two compound libraries were selected and 64 124 amine containing moieties were screened usi
Autor:
Sarel F. Malan, Jacques Joubert, Adaze Bijou Enogieru, Sylvester I. Omoruyi, O E Ekpo, Ireen Denya, Frank T. Zindo, Erika Kapp
Publikováno v:
MedChemComm. 9:357-370
A series of indole derivatives was designed and synthesised to improve on activity and circumvent pharmacokinetic limitations experienced with the structurally related compound, ladostigil. The compounds consisted of a propargylamine moiety (a known
Autor:
Germaine B. Foka, Erika Kapp, Jacques Joubert, Benjamin P. Repsold, Sarel F. Malan, Douglas W. Oliver
Publikováno v:
European Journal of Medicinal Chemistry. 125:853-864
A series of 7-substituted coumarin derivatives were designed and synthesised to display ChE and MAO-B inhibitory activity. The compounds consisted out of a coumarin structure (MAO-B inhibitor) and benzyl-, piperidine-, N -benzylpiperidine- or p -brom
Autor:
Ashraf Grimwood, Geoffrey Fatti, Lizette Monteith, Najma Shaikh, Nicola L. Foster, Erika Kapp
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 71:e107-e113
BACKGROUND: The severe shortage of pharmacists is an important limitation to providing antiretroviral treatment (ART) in resource-limited countries. Two task-shifting pharmaceutical care models have been developed to address this in South Africa name