Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Erika K. Harding"'
Autor:
Charlie H. T. Kwok, Erika K. Harding, Nicole E. Burma, Tamara Markovic, Nicolas Massaly, Nynke J. van den Hoogen, Sierra Stokes-Heck, Eder Gambeta, Kristina Komarek, Hye Jean Yoon, Kathleen E. Navis, Brendan B. McAllister, Julia Canet-Pons, Churmy Fan, Rebecca Dalgarno, Evgueni Gorobets, James W. Papatzimas, Zizhen Zhang, Yuta Kohro, Connor L. Anderson, Roger J. Thompson, Darren J. Derksen, Jose A. Morón, Gerald W. Zamponi, Tuan Trang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive withdrawal symptoms that make it difficult to discontinu
Externí odkaz:
https://doaj.org/article/d65c6d8ddef244efbd66f10b378d8cc2
Autor:
Erika K. Harding, Zizhen Zhang, Julia Canet-Pons, Sierra Stokes-Heck, Tuan Trang, Gerald W. Zamponi
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109972- (2024)
Summary: The ventrolateral periaqueductal gray (vlPAG) functionally projects to diverse brain regions, including the locus coeruleus (LC). Excitatory projections from the vlPAG to the LC are well described, while few studies have indicated the possib
Externí odkaz:
https://doaj.org/article/34c3a51d2ab94763beb36392c4c4545c
Autor:
Laurent Ferron, Erika K. Harding, Maria A. Gandini, Craig Brideau, Peter K. Stys, Gerald W. Zamponi
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109973- (2024)
Summary: N- and P/Q-type voltage-gated Ca2+ channels are critical for synaptic transmission. While their expression is increased in the dorsal root ganglion (DRG) neuron cell bodies during neuropathic pain conditions, less is known about their synapt
Externí odkaz:
https://doaj.org/article/f7dd9b2885184647aa707d0d4f9e7033
Autor:
Erika K. Harding, Gerald W. Zamponi
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-13 (2022)
Abstract Chronic pain is a severely debilitating condition that reflects a long-term sensitization of signal transduction in the afferent pain pathway. Among the key players in this pathway are T-type calcium channels, in particular the Cav3.2 isofor
Externí odkaz:
https://doaj.org/article/92a94640a7fc401b90a1a6d9bf070f36
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2022)
Chronic pain is a complex sensory, cognitive, and emotional experience that imposes a great personal, psychological, and socioeconomic burden on patients. An estimated 1.5 billion people worldwide are afflicted with chronic pain, which is often diffi
Externí odkaz:
https://doaj.org/article/2eb3604bdc59452583f8bab09915ab8a
Publikováno v:
Frontiers in Neural Circuits, Vol 14 (2020)
Somatosensation encompasses a variety of essential modalities including touch, pressure, proprioception, temperature, pain, and itch. These peripheral sensations are crucial for all types of behaviors, ranging from social interaction to danger avoida
Externí odkaz:
https://doaj.org/article/3fc5379bebf549dd9693c5aeb843e861
Autor:
Erika K. Harding, Ivana A. Souza, Maria A. Gandini, Vinícius M. Gadotti, Md Yousof Ali, Sun Huang, Flavia T. T. Antunes, Tuan Trang, Gerald W. Zamponi
Publikováno v:
British Journal of Pharmacology. 180:1616-1633
Publikováno v:
Neuron. 110:4033-4035
Autor:
Terrance P. Snutch, Robert P. Bonin, Annemarie Dedek, Michael W. Salter, Erika K. Harding, Michael E. Hildebrand
Publikováno v:
British Journal of Pharmacology
Background and purpose T-type voltage-gated calcium channels are an emerging potential therapeutic target for neurological disorders including epilepsy and pain. Inhibition of T-type channels reduces the excitability of peripheral nociceptive sensory
Autor:
Erika K. Harding, Gerald W. Zamponi
Publikováno v:
Trends in pharmacological sciences. 43(10)
Chronic pain remains a major burden and is difficult to treat. N-type calcium channels may be a suitable therapeutic target for analgesics, and a new study from Colecraft and colleagues utilizes a clever new way to modulate their expression to achiev