Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Erika G. Pinto"'
Autor:
Lindsay B. Tulloch, Sandra Carvalho, Marta Lima, Richard J. Wall, Michele Tinti, Erika G. Pinto, Lorna MacLean, Susan Wyllie
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTVisceral leishmaniasis (VL) is a parasitic disease endemic across multiple regions of the world and is fatal if untreated. New therapeutic options with diverse mechanisms of actions (MoAs) are required to consolidate progress toward control o
Externí odkaz:
https://doaj.org/article/7bb16e5a50ee43d6b0b2d50b417e7077
Autor:
Erika G. Pinto, Andre G. Tempone
Publikováno v:
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-6 (2018)
Abstract Background Considering the high toxicity and limited therapies available for treating visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to deliver new therapies to the market. Methods In this study, we desc
Externí odkaz:
https://doaj.org/article/32767e074eff4aea82778ec695989957
Autor:
Roberta T. dos Santos, Liliane L. Hiramoto, João Henrique G. Lago, Patrícia Sartorelli, André G. Tempone, Erika G. Pinto
Publikováno v:
Química Nova, Vol 35, Iss 11, Pp 2229-2332 (2012)
MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β
Externí odkaz:
https://doaj.org/article/205ea66551b245ce98d47acff3d8b735
Autor:
Geanne A Alves Conserva, Luis M Quirós-Guerrero, Thais A Costa-Silva, Laurence Marcourt, Erika G Pinto, Andre G Tempone, João Paulo S Fernandes, Jean-Luc Wolfender, Emerson F Queiroz, João Henrique G Lago
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247334 (2021)
EtOH extracts from the leaves and twigs of Nectandra oppositifolia Nees & Mart. shown activity against amastigote forms of Trypanosoma cruzi. These extracts were subjected to successive liquid-liquid partitioning to afford bioactive CH2Cl2 fractions.
Externí odkaz:
https://doaj.org/article/28fee4cc4c4f4c10a111249964cad818
Autor:
Kate McGonagle, Gary J. Tarver, Juan Cantizani, Ignacio Cotillo, Peter G. Dodd, Liam Ferguson, Ian H. Gilbert, Maria Marco, Tim Miles, Claire Naylor, Maria Osuna-Cabello, Christy Paterson, Kevin D. Read, Erika G. Pinto, Jennifer Riley, Paul Scullion, Yoko Shishikura, Frederick Simeons, Laste Stojanovski, Nina Svensen, John Thomas, Paul G. Wyatt, Pilar Manzano, Manu De Rycker, Michael G. Thomas
Publikováno v:
European Journal of Medicinal Chemistry. 238:114421
Approximately 6-7 million people around the world are estimated to be infected with Trypanosoma cruzi, the causative agent of Chagas disease. The current treatments are inadequate and therefore new medical interventions are urgently needed. In this p
Publikováno v:
Chemico-Biological Interactions
Leishmaniasis is a parasitic neglected tropical disease and result in a broad spectrum of clinical manifestations, ranging from a single ulceration to a progressive and fatal visceral disease. Comprising a limited and highly toxic therapeutic arsenal
Autor:
Maiara M. Romanelli, Eduardo Caio Torres-Santos, Andrés Jimenez Galisteo, Juliana Mariotti Guerra, Thais A. Costa-Silva, Erika G. Pinto, Daiane D. Ferreira, Leandro R.S. Barbosa, Edézio Ferreira Cunha-Júnior, Andre G. Tempone
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology
Liposomes containing phosphatidylserine (PS) has been used for the delivery of drugs into the intramacrophage milieu. Leishmania (L.) infantum parasites live inside macrophages and cause a fatal and neglected viscerotropic disease, with a toxic treat
Autor:
Andre G. Tempone, Erika G. Pinto
Publikováno v:
The Journal of Venomous Animals and Toxins Including Tropical Diseases
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-6 (2018)
Journal of Venomous Animals and Toxins including Tropical Diseases v.24 2018
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-6 (2018)
Journal of Venomous Animals and Toxins including Tropical Diseases v.24 2018
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Background: Considering the high toxicity and limited therapies available for treating visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to deliver new therapies to the market. Methods: In this study, we described f
Autor:
Thais A. Costa-Silva, Luis M. Quirós-Guerrero, Erika G. Pinto, Jean-Luc Wolfender, Geanne A. Alves Conserva, Emerson Ferreira Queiroz, Andre G. Tempone, João Henrique G. Lago, Laurence Marcourt, João Paulo S. Fernandes
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247334 (2021)
PLoS ONE
PLoS ONE
EtOH extracts from the leaves and twigs of Nectandra oppositifolia Nees & Mart. shown activity against amastigote forms of Trypanosoma cruzi. These extracts were subjected to successive liquid-liquid partitioning to afford bioactive CH2Cl2 fractions.
Autor:
Erika G. Pinto, João Henrique G. Lago, Kaidu H. Barrosa, Euder Glendes Andrade Martins, Andre G. Tempone
Publikováno v:
Planta Medica. 80:1310-1314
Bioactivity-guided fractionation of the MeOH extract from the leaves of Alchornea glandulosa afforded a new guanidine alkaloid named alchornedine, as well as two other inactive derivatives (pteroginine and pteroginidine). The structure of alchornedin