Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Erika Freemantle"'
Autor:
Camila Pará, Poulomee Bose, Luigi Bruno, Erika Freemantle, Mahsa Taherzadeh, Xuefang Pan, Chanshuai Han, Peter S. McPherson, Jean-Claude Lacaille, Éric Bonneil, Pierre Thibault, Claire O’Leary, Brian Bigger, Carlos Ramon Morales, Graziella Di Cristo, Alexey V. Pshezhetsky
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
The majority of patients affected with lysosomal storage disorders (LSD) exhibit neurological symptoms. For mucopolysaccharidosis type IIIC (MPSIIIC), the major burdens are progressive and severe neuropsychiatric problems and dementia, primarily thou
Externí odkaz:
https://doaj.org/article/410c3252a7a24808ba1808d744c3aabd
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42696 (2012)
Fatty acids (FA) play an integral role in brain function and alterations have been implicated in a variety of complex neurological disorders. Several recent genomic studies have highlighted genetic variability in the fatty acid desaturase (FADS1/2/3)
Externí odkaz:
https://doaj.org/article/22614c63f68f46d98410ce584ad29164
Autor:
Carlos R. Morales, Jean-Claude Lacaille, Erika Freemantle, Chanshuai Han, Camila Pará, Graziella Di Cristo, Claire O'Leary, Pierre Thibault, Mahsa Taherzadeh, Brian W. Bigger, Poulomee Bose, Xuefang Pan, Peter S. McPherson, Luigi Bruno, Eric Bonneil, Alexey V. Pshezhetsky
Publikováno v:
JCI Insight
The majority of patients affected with lysosomal storage disorders (LSD) exhibit neurological symptoms. For mucopolysaccharidosis type IIIC (MPSIIIC), the major burdens are progressive and severe neuropsychiatric problems and dementia, primarily thou
Autor:
Shane Wiebe, Karim Nader, Argel Aguilar-Valles, Vinh Tai Truong, Ilse Gantois, Seyed Mehdi Jafarnejad, Jean-Claude Lacaille, Clément Chapat, Nahum Sonenberg, Vijendra Sharma, Jelena Popic, Erika Freemantle, Christos G. Gkogkas, Isabelle A. Groves, Anmol Nagpal, Tine Pooters, Agnieszka Skalecka, Karine Gamache, Arkady Khoutorsky, Ruifeng Cao, Elizabeth A. McCullagh
Publikováno v:
Gantois, I, Khoutorsky, A, Popic, J, Aguilar-Valles, A, Freemantle, E, Cao, R, Sharma, V, Pooters, T, Nagpal, A, Skalecka, A, Truong, V T, Wiebe, S, Groves, I A, Jafarnejad, S M, Chapat, C, McCullagh, E A, Gamache, K, Nader, K, Lacaille, J-C, Gkogkas, C G & Sonenberg, N 2017, ' Metformin ameliorates core deficits in a mouse model of fragile X syndrome ', Nature Medicine, vol. 23, pp. 674-677 . https://doi.org/10.1038/nm.4335
Fragile X syndrome (FXS) is the leading monogenic cause of autism spectrum disorders (ASD). Trinucleotide repeat expansions in FMR1 abolish FMRP expression, leading to hyperactivation of ERK and mTOR signaling upstream of mRNA translation. Here we sh
Autor:
Kim Eerola, Francesca Marchisella, Benjamin D. Peterson, Patrik Hollos, Natalia Kulesskaya, Eleanor T. Coffey, Sylvia Ortega-Martínez, Hasan Mohammad, Emilia Komulainen, H van Praag, Erika Freemantle, E Savontous, Heikki Rauvala, Veronica Fagerholm
Publikováno v:
Molecular Psychiatry
Promoting adult hippocampal neurogenesis is expected to induce neuroplastic changes that improve mood and alleviate anxiety. However, the underlying mechanisms remain largely unknown and the hypothesis itself is controversial. Here we show that mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543e8e31fc641774e7bf661ea32219fc
http://hdl.handle.net/10138/233496
http://hdl.handle.net/10138/233496
Autor:
Tommy Alain, Tyson E. Graber, Jean-Claude Lacaille, Mina N. Anadolu, Erika Freemantle, Robyn L. MacAdam, Sarah Hébert-Seropian, Wayne S. Sossin, Huy-Dung Hoang, Unkyung Shin
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(38)
Neuronal mRNAs can be packaged in reversibly stalled polysome granules before their transport to distant synaptic locales. Stimulation of synaptic metabotropic glutamate receptors (mGluRs) reactivates translation of these particular mRNAs to produce
Autor:
Corina Nagy, Erika Freemantle, Gustavo Turecki, Guy A. Rouleau, Martin Alda, Cristiana Cruceanu
Publikováno v:
International Journal of Neuropsychopharmacology. 16:289-299
The synapsin family of neuronal phosphoproteins is composed of three genes (SYN1, SYN2 and SYN3) with alternative splicing resulting in a number of variants with various levels of homology. These genes have been postulated to play significant roles i
Autor:
Milène Vandal, Fabien Pifferi, Jennifer Tremblay-Mercier, Stephen C. Cunnane, Mélanie Fortier, Michel E. Bégin, Mélanie Plourde, Erika Freemantle
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids
Prostaglandins, Leukotrienes and Essential Fatty Acids, Elsevier, 2007, 77 (5-6), pp.301-308. ⟨10.1016/j.plefa.2007.10.024⟩
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2007, 77 (5-6), pp.301-308. ⟨10.1016/j.plefa.2007.10.024⟩
Prostaglandins, Leukotrienes and Essential Fatty Acids, Elsevier, 2007, 77 (5-6), pp.301-308. ⟨10.1016/j.plefa.2007.10.024⟩
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2007, 77 (5-6), pp.301-308. ⟨10.1016/j.plefa.2007.10.024⟩
Lower consumption of docosahexaenoic acid (DHA) is commonly but not always associated with higher risk of cognitive decline and diagnosis of Alzheimer's disease (AD). We review here the available data relating DHA to AD, with emphasis on DHA content
Autor:
Milène Vandal, Michel E. Bégin, Jennifer Tremblay-Mercier, Erika Freemantle, Mélanie Plourde, Stephen C. Cunnane
Publikováno v:
Oléagineux, Corps gras, Lipides, Vol 14, Iss 3-4, Pp 177-181 (2007)
Prospective cohort studies and animal models support the concept that low docosahexaenoic acid intake is implicated in the etiology or progression of Alzheimer’s disease. However, other studies crucial to this relationship are less encouraging. To
Publikováno v:
Neuropsychopharmacology. 38:239-241
The synapsins are a family of neuronal phosphoproteins consisting of SYN1 at chrXp11.3, SYN2 at chr3p25, and SYN3 at chr22q12.3 with alternative splicing leading to as many as 10 isoforms. They are involved in synaptic transmission and plasticity, as