Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Erika Casari"'
Autor:
Michela Galli, Chiara Frigerio, Chiara Vittoria Colombo, Erika Casari, Maria Pia Longhese, Michela Clerici
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110410- (2024)
Summary: Tel1/ataxia telangiectasia mutated (ATM) kinase plays multiple functions in response to DNA damage, promoting checkpoint-mediated cell-cycle arrest and repair of broken DNA. In addition, Saccharomyces cerevisiae Tel1 stabilizes replication f
Externí odkaz:
https://doaj.org/article/fb1b6b462b644715b8a993a807cb0185
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110373- (2024)
Summary: Homologous recombination is initiated by the nucleolytic degradation (resection) of DNA double-strand breaks (DSBs). DSB resection is a two-step process. In the short-range step, the MRX (Mre11-Rad50-Xrs2) complex, together with Sae2, incise
Externí odkaz:
https://doaj.org/article/005a8cfcaad84c2196cb2a5f63050469
Autor:
Erika Casari, Paolo Pizzul, Carlo Rinaldi, Marco Gnugnoli, Michela Clerici, Maria Pia Longhese
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113360- (2023)
Summary: DNA damage elicits a checkpoint response depending on the Mec1/ATR kinase, which detects the presence of single-stranded DNA and activates the effector kinase Rad53/CHK2. In Saccharomyces cerevisiae, one of the signaling circuits leading to
Externí odkaz:
https://doaj.org/article/e5a235e7d82741c1906f75bd2f41209b
Autor:
Erika Casari, Elisa Gobbini, Marco Gnugnoli, Marco Mangiagalli, Michela Clerici, Maria Pia Longhese
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The histone folding protein Dpb4 forms histone-like dimers within the ISW2 complex and the Pol ε complex in S. cerevisiae. Here the authors reveal insights into two distinct functions that Dpb4 exerts at DSBs depending on its interactors.
Externí odkaz:
https://doaj.org/article/308e440c9f65443c829e70f044d62f42
Autor:
Paolo Pizzul, Erika Casari, Marco Gnugnoli, Carlo Rinaldi, Flavio Corallo, Maria Pia Longhese
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Studies performed in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe have led the way in defining the DNA damage checkpoint and in identifying most of the proteins involved in this regulatory network, which turned out to have struct
Externí odkaz:
https://doaj.org/article/5f64489a026446b5874afaa79be51d82
Autor:
Erika Casari, Marco Gnugnoli, Carlo Rinaldi, Paolo Pizzul, Chiara Vittoria Colombo, Diego Bonetti, Maria Pia Longhese
Publikováno v:
Cells, Vol 11, Iss 20, p 3224 (2022)
Early work by Muller and McClintock discovered that the physical ends of linear chromosomes, named telomeres, possess an inherent ability to escape unwarranted fusions. Since then, extensive research has shown that this special feature relies on spec
Externí odkaz:
https://doaj.org/article/79fd461168b14762b39a5c02ee1060b7
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009807 (2021)
Repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) requires that the 5'-terminated DNA strands are resected to generate single-stranded DNA overhangs. This process is initiated by a short-range resection catalyzed by the MRX (
Externí odkaz:
https://doaj.org/article/bf785901828e4d50aea3d20a881a9212
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108287- (2020)
Summary: Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs). DSB resection is a two-step process in which an initial short-range step is catalyzed by the Mre11-Rad50-Xrs2 (MRX) complex and
Externí odkaz:
https://doaj.org/article/8788204961c1485f8f14ff233146332e
Autor:
Erika Casari, Carlo Rinaldi, Antonio Marsella, Marco Gnugnoli, Chiara Vittoria Colombo, Diego Bonetti, Maria Pia Longhese
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
DNA double-strand breaks (DSBs) are highly cytotoxic lesions that must be repaired to ensure genomic stability and avoid cell death. The cellular response to DSBs is initiated by the evolutionarily conserved Mre11-Rad50-Xrs2/NBS1 (MRX/MRN) complex th
Externí odkaz:
https://doaj.org/article/02857ddb75954b589733cfeba7178062
Autor:
Carlo Rinaldi, Paolo Pizzul, Erika Casari, Marco Mangiagalli, Renata Tisi, Maria Pia Longhese
DNA double-strand breaks (DSBs) can be repaired by either homologous recombination (HR) or non-homologous end-joining (NHEJ). NHEJ is induced by the binding to DSBs of the Ku70–Ku80 heterodimer, which acts as a hub for the recruitment of downstream
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca28852cf333276a0bab7c708962f388
https://hdl.handle.net/10281/403662
https://hdl.handle.net/10281/403662
