Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Erika B Villanueva"'
Autor:
Amber L. Southwell, Sonia Franciosi, Erika B. Villanueva, Yuanyun Xie, Laurie A. Winter, Janaki Veeraraghavan, Alan Jonason, Boguslaw Felczak, Weining Zhang, Vlad Kovalik, Sabine Waltl, George Hall, Mahmoud A. Pouladi, Ernest S. Smith, William J. Bowers, Maurice Zauderer, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 76, Iss , Pp 46-56 (2015)
Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-modifying therapy currently available. In addition to characteristic motor deficits and atrophy of the caudate nucleus, signature hallmarks of HD include behavio
Externí odkaz:
https://doaj.org/article/99a93dc1282c4cf6b5dc56f2438c4a79
Autor:
Emilie Tresse, Joao N. Duarte, Gisela Jimenez-Duran, Shohreh Issazadeh-Navikas, Oliver Kretz, Desiree Loreth, Tobias Goldmann, Yawei Liu, Erika B Villanueva, Marco Prinz, Patrick Ejlerskov
Publikováno v:
Villanueva, E B, Tresse, E, Liu, Y, Duarte, J N, Jimenez-Duran, G, Ejlerskov, P, Kretz, O, Loreth, D, Goldmann, T, Prinz, M & Issazadeh-Navikas, S 2021, ' Neuronal TNFα, not α-syn, underlies PDD-like disease progression in IFNβ-KO mice ', Annals of Neurology, vol. 90, no. 5, pp. 789-807 . https://doi.org/10.1002/ana.26209
OBJECTIVE: Parkinson's disease (PD) manifests in motor dysfunction, non-motor symptoms, and eventual dementia (PDD). Neuropathological hallmarks include nigrostriatal neurodegeneration, Lewy body (LB) pathology, and neuroinflammation. Alpha-synuclein
Autor:
Sabine Waltl, Dagmar E. Ehrnhoefer, Boguslaw Felczak, Lorenzo Casal, Amber L. Southwell, Meenalochani Sivasubramanian, Lisa M. Anderson, Anita Fazeli, Xiaofan Qiu, Erika B. Villanueva, Yuanyun Xie, Michelle Tsang, Michael R. Hayden
Publikováno v:
Human Molecular Genetics. 27:239-253
Oxidative stress is a prominent feature of Huntington disease (HD), and we have shown previously that reduced levels of hace1 (HECT domain and Ankyrin repeat containing E3 ubiquitin protein ligase 1) in patient striatum may contribute to the pathogen
Autor:
Amber L. Southwell, Hailey Findlay-Black, Yuanyun Xie, Bethany Fitsimmons, Michael E. Østergaard, C. Frank Bennett, Niels H. Skotte, Louisa Dal Cengio, Punit P. Seth, Crystal N. Doty, Michael R. Hayden, Erika B. Villanueva, Douglas R. Langbehn, Lynn A. Raymond, Lisa M. Anderson, Holly B. Kordasiewicz, Eric E. Swayze, Matthew P. Parsons, Nicholas S. Caron
Publikováno v:
Science Translational Medicine. 10
Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin (HTT) protein, resulting in acquisition of toxic functions. Previous studies have shown that lowering mutant HTT has the potential to b
Autor:
Alberto Siddu, Abid Oueslati, Halyna Pankevych, Yuanyun Xie, Oskar W. Smrzka, Francesca Cicchetti, Amber L. Southwell, Louisa Dal Cengio, Michael R. Hayden, Michela Parth, Markus Burkert, Seungyun Ko, Nina Salhat, Linda Suzanne David, Erika B. Villanueva, Stefan Bartl
Publikováno v:
Experimental therapeutics – preclinical.
The toxic functions of the mutant Huntingtin protein (mutHTT) were studied extensively and in addition to neuronal based symptoms, also peripheral changes upon mutHTT expression were described. An important finding in Huntington’s disease (HD) rese
Autor:
Boguslaw Felczak, Sabine Waltl, George Hall, Erika B. Villanueva, Yuanyun Xie, Michael R. Hayden, Weining Zhang, Ernest S. Smith, Amber L. Southwell, Maurice Zauderer, Vlad Kovalik, Laurie A. Winter, Alan S. Jonason, Sonia Franciosi, William J. Bowers, Mahmoud A. Pouladi, Janaki Veeraraghavan
Publikováno v:
Neurobiology of Disease, Vol 76, Iss, Pp 46-56 (2015)
Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-modifying therapy currently available. In addition to characteristic motor deficits and atrophy of the caudate nucleus, signature hallmarks of HD include behavio
Autor:
Holly Kordasiewicz, Michael R. Hayden, Clarence Frank Bennett, Crystal N. Doty, Erika B. Villanueva, Punit P. Seth, Kuljeet Vaid, Susan M. Freier, Niels H. Skotte, Eugenia Petoukhov, Amber L. Southwell, Jeffrey B. Carroll, Michael E. Østergaard, Eric E. Swayze, Andrew T. Watt, Yuanyun Xie
Publikováno v:
Molecular Therapy. 22:2093-2106
Huntington disease (HD) is a dominant, genetic neurodegenerative disease characterized by progressive loss of voluntary motor control, psychiatric disturbance, and cognitive decline, for which there is currently no disease-modifying therapy. HD is ca
Autor:
Svetlana Simtchouk, Nichole E. Gill, Kirsten R. Wolthers, Erika B. Villanueva, Jonathan P. Little, Andis Klegeris, Douglas G. Walker, Stephanie M. Schindler
Publikováno v:
Molecular and Cellular Neuroscience. 60:88-96
Microglia represent mononuclear phagocytes in the brain and perform immune surveillance, recognizing a number of signaling molecules released from surrounding cells in both healthy and pathological situations. The microglia interact with several dama
Autor:
Michael R. Hayden, X. William Yang, Erika B. Villanueva, Niels H. Skotte, Crystal N. Doty, Amber L. Southwell, Jeffrey B. Carroll, Vlad Kovalik, Sonia Franciosi, Weining Zhang, Mahmoud A. Pouladi, Jennifer A. Collins, Simon C. Warby, Yuanyun Xie
Publikováno v:
Human Molecular Genetics. 22:18-34
Silencing the mutant huntingtin gene (muHTT) is a direct and simple therapeutic strategy for the treatment of Huntington disease (HD) in principle. However, targeting the HD mutation presents challenges because it is an expansion of a common genetic
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 11:582-590
The cannabinoid system is represented by two principal receptor subtypes, termed CB1 and CB2, along with several endogenous ligands. In the central nervous system it is involved in several processes. CB1 receptors are mainly expressed by neurons and