Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response

Autor: Graeme R. Grimes, Erika Abbondati, Martin A M Reijns, Ailsa Revuelta, Adeline Fluteau, Robert E. Hill, Žygimantė Tarnauskaitė, Paul S. Devenney, Rachel E. Rigby, Karen J. Mackenzie, Fiona Kilanowski, Andrew P. Jackson, Björn Rabe, Laura A. Lettice, Flora L. Dix, Kaalak Reddy, Paula Carroll

Publikováno v: Mackenzie, K J, Carroll, P, Lettice, L, Tarnauskaite, Z, Reddy, K, Dix, F, Revuelta, A, Abbondati, E, Rigby, R E, Rabe, B, Kilanowski, F, Grimes, G R, Fluteau, A, Devenney, P S, Hill, R E, Reijns, M A M & Jackson, A P 2016, ' Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response ', EMBO Journal, vol. 35, no. 8, pp. 831-844 . https://doi.org/10.15252/embj.201593339

Aicardi–Goutières syndrome (AGS) provides a monogenic model of nucleic acid‐mediated inflammation relevant to the pathogenesis of systemic autoimmunity. Mutations that impair ribonuclease (RNase) H2 enzyme function are the most frequent cause of

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https://www.pure.ed.ac.uk/ws/files/24272499/Ribonclease_H2_mutationas_induce_a_cGAS_STING_dependent_innate_immune_response.pdf