Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Erika A. de Wynter"'
Autor:
Richard D. Unwin, Erika A. de Wynter
Publikováno v:
PROTEOMICS. 9:3630-3634
This report summarises the recent "Perspectives in Stem Cell Proteomics" meeting that was held at the Wellcome Trust Conference Centre, Hinxton, UK in March 2009. The aim of the meeting was to explore the current status of proteomics in stem cell bio
Autor:
C. Hart, Clare M. Heyworth, Yvonne J. Summers, Erika A. de Wynter, Nydia G Testa, James Chang
Publikováno v:
STEM CELLS. 22:704-715
AC133+ cells may provide an alternative to CD34+ cells as a target for cell expansion and gene therapy protocols. We examined the differences in proliferative potential between cord blood selected for AC133 or CD34 in serum-free, stroma cell-free cul
Autor:
Nydia G Testa, Erika A. de Wynter
Publikováno v:
Current Paediatrics. 12:310-315
The advances in methodology that facilitated analysis of defined populations of stem and progenitor cells and the detection of growth factors and their purification in recombinant form, have also allowed us to formulate sharp definitions of discrete
Autor:
Malcolm R. Alison, Horst Spielmann, S. Knaan-Shanzer, Erika A. de Wynter, Susanne Bremer, Peter J. Donovan, Laura Gribaldo, Roland Mertelsmann, Peter W. Andrews, Nydia G Testa, Dov Zipori, James T. Triffitt
Publikováno v:
Experimental Hematology. 30:628-633
Publikováno v:
STEM CELLS. 19:505-513
We examined the functional differences between G(0) and G(1) cord blood CD34+ cells for up to 24 weeks in serum-free suspension culture, containing Flt-3 ligand, thrombopoietin and stem cell factor. By week 24, there is more than a 1,000-fold differe
Autor:
Ewa Jaworska, Kouji Matushima, Naofumi Mukaida, Nydia G. Testa, Almeriane Weffort-Santos, Clare M. Heyworth, Erika A. de Wynter
Publikováno v:
Journal of Leukocyte Biology. 70:455-460
Simple methods that separate progenitor cells of different hemopoietic lineages would facilitate studies on lineage commitment and differentiation. We used an antibody specific for the chemokine receptor CCR1 to examine mononuclear cells isolated fro
Autor:
Nydia G Testa, James Chang, Christoph Kasper, Jan Dürig, Michael Cross, Clare M. Heyworth, Erika A. de Wynter
Publikováno v:
Blood. 92:3073-3081
Macrophage inflammatory protein-1 (MIP-1) can stimulate growth inhibitory and potent chemotactic functions in hematopoietic cells. To investigate whether the action of MIP-1 may be regulated at the cellular receptor level, we studied the exp
Autor:
Erika A. de Wynter, Nydia G Testa, John T. Gallagher, Martin J. Humphries, Karen P. Schofield
Publikováno v:
Blood. 91:3230-3238
Highly regulated interactions between adhesion receptors on progenitor cells and their extracellular matrix ligands are essential for the control of hematopoiesis in bone marrow stroma. We have examined the relationship between α4β1-integrin–medi
Autor:
Ruth Pettengell, Thomas Luft, Lesley Fitzsimmons, J. Howard Scarffe, Nydia G Testa, Erika A. de Wynter, L. H. Coutinho, Rosemary Young
Publikováno v:
British Journal of Haematology. 89:237-242
Twenty-seven patients with advanced adenocarcinoma were studied. Groups of three patients received interleukin-6 (IL-6) in doses ranging from 0.5 to 20 micrograms/kg by daily subcutaneous injection on days 1-7 and 22-49. Four patients received IL-6 2
Autor:
Michael F. McDermott, Tim D. Holmes, Liz Straszynski, Erika A. de Wynter, Peter Brett, Paul A. S. Ballard, Joseph A. Trapani, Erica B. Wilson, Josephine L. Meade, Graham P. Cook
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 183(2)
NK cells induce apoptosis in target cells via the perforin-mediated delivery of granzyme molecules. Cytotoxic human NK cells can be generated by IL-15-mediated differentiation of CD34+ cells in vitro and these cultures have been used extensively to a