Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Erika A. Bach"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 8, Pp 2609-2622 (2019)
Cell competition is the elimination of one viable population of cells (the losers) by a neighboring fitter population (the winners) and was discovered by studies in the Drosophila melanogaster wing imaginal disc. Supercompetition is a process in whic
Externí odkaz:
https://doaj.org/article/fe9e216c15ac4027b5f1aa9b84b99ccb
Autor:
Salvador C. Herrera, Erika A. Bach
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5519 (2021)
The Jun N-terminal kinase (JNK) pathway is an evolutionary conserved kinase cascade best known for its roles during stress-induced apoptosis and tumor progression. Recent findings, however, have identified new roles for this pleiotropic pathway in st
Externí odkaz:
https://doaj.org/article/42ce08a0452d488fab4f9a86d12e5270
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2427-2438 (2017)
A gain-of-function mutation in the tyrosine kinase JAK2 (JAK2V617F) causes human myeloproliferative neoplasms (MPNs). These patients present with high numbers of myeloid lineage cells and have numerous complications. Since current MPN therapies are n
Externí odkaz:
https://doaj.org/article/3e8b49aadd684781beed978efafe2100
Autor:
Alessandro A. Bailetti, Lenny J. Negrón-Piñeiro, Vishal Dhruva, Sneh Harsh, Sean Lu, Aisha Bosula, Erika A. Bach
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 5 (2019)
Myeloproliferative neoplasms (MPNs) are clonal hematopoietic disorders that cause excessive production of myeloid cells. Most MPN patients have a point mutation in JAK2 (JAK2V617F), which encodes a dominant-active kinase that constitutively triggers
Externí odkaz:
https://doaj.org/article/6431b3b620cb4444a4b18048454a0da6
Autor:
Gyeong-Hun Baeg, Dennis G. Hall, Agnieszka Ulaczyk-Lesanko, Somasundaram Jayabose, Claudio Sandoval, Haeryun Lee, Erika A. Bach, Qianxu Guo, Chang-Hong Yin, Byung Hak Kim
Supplementary Fig. S1 from A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935f6e4244df9b63086bad4bc7679eb1
https://doi.org/10.1158/1535-7163.22484498.v1
https://doi.org/10.1158/1535-7163.22484498.v1
Autor:
Gyeong-Hun Baeg, Dennis G. Hall, Agnieszka Ulaczyk-Lesanko, Somasundaram Jayabose, Claudio Sandoval, Haeryun Lee, Erika A. Bach, Qianxu Guo, Chang-Hong Yin, Byung Hak Kim
Inappropriate activation of JAK/STAT signaling occurs with high frequency in human cancers and is associated with cancer cell survival and proliferation. Therefore, the development of pharmacologic STAT signaling inhibitors has therapeutic potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6688fe0700d1e5981d8168d55b9367f2
https://doi.org/10.1158/1535-7163.c.6531431
https://doi.org/10.1158/1535-7163.c.6531431