Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Erika A Bach"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 4 (2021)
AbstractOne of the best examples of sexual dimorphism is the development and function of the gonads, ovaries and testes, which produce sex-specific gametes, oocytes, and spermatids, respectively. The development of these specialized germ cells requir
Externí odkaz:
https://doaj.org/article/2eb6cef54782482a8b484edb2b033394
Autor:
Salvador C Herrera, Erika A Bach
Publikováno v:
eLife, Vol 7 (2018)
Exhaustion of stem cells is a hallmark of aging. In the Drosophila testis, dedifferentiated germline stem cells (GSCs) derived from spermatogonia increase during lifespan, leading to the model that dedifferentiation counteracts the decline of GSCs in
Externí odkaz:
https://doaj.org/article/0af6061eaa3a44f899f3550d6d7fb516
Publikováno v:
PLoS Genetics, Vol 14, Iss 2, p e1007203 (2018)
Reproduction in sexually dimorphic animals relies on successful gamete production, executed by the germline and aided by somatic support cells. Somatic sex identity in Drosophila is instructed by sex-specific isoforms of the DMRT1 ortholog Doublesex
Externí odkaz:
https://doaj.org/article/1a62b6363e8b4722845390ab3f57bf66
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005815 (2016)
The Drosophila testis is a well-established system for studying stem cell self-renewal and competition. In this tissue, the niche supports two stem cell populations, germ line stem cells (GSCs), which give rise to sperm, and somatic stem cells called
Externí odkaz:
https://doaj.org/article/10fdb1f4192e48dba7a65eef64cc12f8
Autor:
Rachel A. Hodge, Erika A. Bach
Publikováno v:
Life, Vol 14, Iss 10, p 1251 (2024)
In this review, we introduce the concept of cell competition, which occurs between heterogeneous neighboring cell populations. Cells with higher relative fitness become “winners” that outcompete cells of lower relative fitness (“losers”). We
Externí odkaz:
https://doaj.org/article/6d5a4ea67aba494a95f021ad0681a03a
Autor:
Gyeong-Hun Baeg, Dennis G. Hall, Agnieszka Ulaczyk-Lesanko, Somasundaram Jayabose, Claudio Sandoval, Haeryun Lee, Erika A. Bach, Qianxu Guo, Chang-Hong Yin, Byung Hak Kim
Supplementary Fig. S1 from A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935f6e4244df9b63086bad4bc7679eb1
https://doi.org/10.1158/1535-7163.22484498.v1
https://doi.org/10.1158/1535-7163.22484498.v1
Autor:
Gyeong-Hun Baeg, Dennis G. Hall, Agnieszka Ulaczyk-Lesanko, Somasundaram Jayabose, Claudio Sandoval, Haeryun Lee, Erika A. Bach, Qianxu Guo, Chang-Hong Yin, Byung Hak Kim
Inappropriate activation of JAK/STAT signaling occurs with high frequency in human cancers and is associated with cancer cell survival and proliferation. Therefore, the development of pharmacologic STAT signaling inhibitors has therapeutic potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6688fe0700d1e5981d8168d55b9367f2
https://doi.org/10.1158/1535-7163.c.6531431
https://doi.org/10.1158/1535-7163.c.6531431