Výsledky vyhledávání - "Erika, Gurzeler"

Akademický článek

SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice

Autor: Erika Gurzeler, Anna-Kaisa Ruotsalainen, Anssi Laine, Teemu Valkama, Sanna Kettunen, Markku Laakso, Seppo Ylä-Herttuala

Publikováno v: PLoS ONE, Vol 16, Iss 11 (2021)

Background and aims Diabetes is a major risk factor of atherosclerosis and its complications. The loss-of-function mutation E1506K in the sulfonylurea receptor 1 (SUR1-E1506K) induces hyperinsulinemia in infancy, leading to impaired glucose tolerance

Externí odkaz: https://doaj.org/article/95ff50082cac4d4ab98c60aaa8e93e1f

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Akademický článek

Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice.

Autor: Mari Merentie, Riina Rissanen, Line Lottonen-Raikaslehto, Jenni Huusko, Erika Gurzeler, Mikko P Turunen, Lari Holappa, Petri Mäkinen, Seppo Ylä-Herttuala

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0190981 (2018)

Vascular endothelial growth factor-A (VEGF-A) is the master regulator of angiogenesis, vascular permeability and growth. However, its role in mature blood vessels is still not well understood. To better understand the role of VEGF-A in the adult vasc

Externí odkaz: https://doaj.org/article/53147f53257445b287a978129a263daf

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Akademický článek

Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart

Autor: Nikolay Naumenko, Jenni Huusko, Tomi Tuomainen, Jussi T. Koivumäki, Mari Merentie, Erika Gurzeler, Kari Alitalo, Riikka Kivelä, Seppo Ylä-Herttuala, Pasi Tavi

Publikováno v: Frontiers in Physiology, Vol 8 (2017)

Vascular endothelial growth factor B (VEGF-B) is a potent mediator of vascular, metabolic, growth, and stress responses in the heart, but the effects on cardiac muscle and cardiomyocyte function are not known. The purpose of this study was to assess

Externí odkaz: https://doaj.org/article/67b7ea8e91684a2a96e280d6e14ddf63

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Therapeutic effects of rosuvastatin in hypercholesterolemic prediabetic mice in the absence of low density lipoprotein receptor

Autor: Erika Gurzeler, Henri Niskanen, Jenni Huusko, Einari Aavik, Anssi Laine, Minna U. Kaikkonen, Seppo Ylä-Herttuala, Teemu Valkama

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:481-490

Statins are effective drugs used to prevent and treat cardiovascular diseases but their effects in the absence of low density lipoprotein receptor (LDLR) and on the risk of diabetes are not yet well characterized. The aim of this study was to clarify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f3caf2405c249a4751df7b1703c205
https://doi.org/10.1016/j.bbagen.2018.11.012

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In vivo inhibition of nuclear factor of activated T-cells leads to atherosclerotic plaque regression in IGF-II/LDLR–/–ApoB100/100 mice

Autor: Ann-Cathrine Jönsson-Rylander, Olga Kotova, Maria F. Gomez, Seppo Ylä-Herttuala, Anna-Maria Dutius Andersson, Lisa Berglund, Suvi E. Heinonen, Erika Gurzeler, Fabiana Blanco

Publikováno v: Diabetes & Vascular Disease Research

Aims: Despite vast clinical experience linking diabetes and atherosclerosis, the molecular mechanisms leading to accelerated vascular damage are still unclear. Here, we investigated the effects of nuclear factor of activated T-cells inhibition on pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8559fe87377fc2c71a0c940e2660d59f
http://europepmc.org/articles/PMC6039864

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Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice

Autor: Line Lottonen-Raikaslehto, Mikko P. Turunen, Lari Holappa, Petri I. Mäkinen, Jenni Huusko, Erika Gurzeler, Seppo Ylä-Herttuala, Riina Rissanen, Mari Merentie

Publikováno v: PLOS ONE
PLoS ONE
PLoS ONE, Vol 13, Iss 1, p e0190981 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e7a87b8d7563a1f2738dd7753ce19b

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Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice

Autor: Thomas L. Theelen, Mat J.A.P. Daemen, Jari P. Lappalainen, Erik A.L. Biessen, Jack P.M. Cleutjens, Marion J.J. Gijbels, Judith C. Sluimer, Erika Gurzeler, Kari Alitalo, Seppo Ylä-Herttuala

Publikováno v: Atherosclerosis
Atherosclerosis, 241(2), 297-304. Elsevier Ireland Ltd

Objective Angiopoietin-2 (Ang-2) blocking agents are currently undergoing clinical trials for use in cancer treatment. Ang-2 has also been associated with rupture-prone atherosclerotic plaques in humans, suggesting a role for Ang-2 in plaque stabilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44265dc3be51734e2ae52133e0ecec8f
https://doi.org/10.1016/j.atherosclerosis.2015.05.018

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High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy

Autor: Søren K. Moestrup, Galina Dragneva, Christian Brix Folsted Andersen, Jenni Huusko, Marike H. Dijkstra, Erika Gurzeler, Seppo Ylä-Herttuala, Annukka M. Kivelä, Anssi Laine

Publikováno v: Kivelä, A M, Huusko, J, Gurzeler, E, Laine, A, Dijkstra, M H, Dragneva, G, Andersen, C B F, Moestrup, S K & Ylä-Herttuala, S 2017, ' High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy ', Scientific Reports, vol. 7, no. 1, pp. 386 . https://doi.org/10.1038/s41598-017-00376-5
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)

Adenoviruses are very efficient vectors for delivering therapeutic genes in preclinical and clinical trials. However, randomized controlled human trials have often been lacking clear clinically relevant results. We hypothesized that high lipid levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e97b6fa4a7773262d4fe1d236740b8
https://erepo.uef.fi/handle/123456789/5011

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