Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Erik Zupa"'
Autor:
Erik Zupa, Martin Würtz, Annett Neuner, Thomas Hoffmann, Mandy Rettel, Anna Böhler, Bram J. A. Vermeulen, Sebastian Eustermann, Elmar Schiebel, Stefan Pfeffer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The formation of branched microtubule networks in mitotic spindles depends on the augmin complex. Zupa, Würtz et al. elucidate the molecular architecture and conformational plasticity of the augmin complex using integrative structural biology, provi
Externí odkaz:
https://doaj.org/article/e19cf2fde40d4b8da95d71372a89e235
Autor:
Martin Würtz, Erik Zupa, Enrico S. Atorino, Annett Neuner, Anna Böhler, Ariani S. Rahadian, Bram J. A. Vermeulen, Giulia Tonon, Sebastian Eustermann, Elmar Schiebel, Stefan Pfeffer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The human microtubule nucleator γ-TuRC is composed of more than thirty subunits, including actin. Here the authors reveal the structural mechanism of modular γ-TuRC assembly and show a functional role of actin in microtubule nucleation.
Externí odkaz:
https://doaj.org/article/1aa7f3db771a4f54a4b01bc808055e8e
Autor:
Erik Zupa, Anjun Zheng, Annett Neuner, Martin Würtz, Peng Liu, Anna Böhler, Elmar Schiebel, Stefan Pfeffer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The nucleation of microtubules from αβ-tubulin subunits is mediated by γtubulin complexes, which vary in composition across organisms. Here, authors present the cryo-EM structure of the heterotetrameric γ-tubulin small complex (γ-TuSC) from C. a
Externí odkaz:
https://doaj.org/article/c3b177b1e448457da20ea32c914c464f
Autor:
Martin Würtz, Anna Böhler, Annett Neuner, Erik Zupa, Lukas Rohland, Peng Liu, Bram J. A. Vermeulen, Stefan Pfeffer, Sebastian Eustermann, Elmar Schiebel
Publikováno v:
Open Biology, Vol 11, Iss 2 (2021)
Cryo-electron microscopy recently resolved the structure of the vertebrate γ-tubulin ring complex (γ-TuRC) purified from Xenopus laevis egg extract and human cells to near-atomic resolution. These studies clarified the arrangement and stoichiometry
Externí odkaz:
https://doaj.org/article/65cd1acffb524313ace0d2d4370359f0
Publikováno v:
Current Opinion in Structural Biology. 66:15-21
The nucleation of microtubules from αβ-tubulin dimers is an essential cellular process dependent on γ-tubulin complexes. Mechanistic understanding of the nucleation reaction was hampered by the lack of γ-tubulin complex structures at sufficiently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb1f9f1f7b7ad14e8d078570e6c7fce
https://doi.org/10.1016/j.sbi.2020.08.008
https://doi.org/10.1016/j.sbi.2020.08.008
Publikováno v:
Current Opinion in Cell Biology. 68:124-131
Microtubules are essential cytoskeletal elements assembled from αβ-tubulin dimers. In high eukaryotes, microtubule nucleation, the de novo assembly of a microtubule from its minus end, is initiated by the γ-tubulin ring complex (γ-TuRC). Despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b93141341fdc93db07a907012f2f05
https://doi.org/10.1016/j.ceb.2020.10.004
https://doi.org/10.1016/j.ceb.2020.10.004
Autor:
Stefan Pfeffer, Annett Neuner, Anjun Zheng, Erik Zupa, Martin Würtz, Elmar Schiebel, Peng Liu, Anna Böhler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
The nucleation of microtubules from αβ-tubulin subunits is mediated by γ-tubulin complexes, which vary in composition across organisms. Aiming to understand how de novo microtubule formation is achieved and regulated by a minimal microtubule nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7f303fe129621c1c261c9313299e88
https://doaj.org/article/c3b177b1e448457da20ea32c914c464f
https://doaj.org/article/c3b177b1e448457da20ea32c914c464f
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biologyREFERENCES. 43(8)
Microtubules are protein cylinders with functions in cell motility, signal sensing, cell organization, intracellular transport, and chromosome segregation. One of the key properties of microtubules is their dynamic architecture, allowing them to grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a742b71311501cd49c0c6aefbf6ba1
https://pubmed.ncbi.nlm.nih.gov/34160844
https://pubmed.ncbi.nlm.nih.gov/34160844
Autor:
Martin Würtz, Stefan Pfeffer, Erik Zupa, Annett Neuner, Elmar Schiebel, Sebastian Eustermann, Bram J. A. Vermeulen, Peng Liu, Anna Böhler, Lukas Rohland
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a72f33811f184df83b28b9073468749d
https://doi.org/10.1098/rsob.200325/v2/response1
https://doi.org/10.1098/rsob.200325/v2/response1
Autor:
Thomas Ruppert, Justus Loerke, Stefan Pfeffer, Erik Zupa, Christoph Peter, Annett Neuner, Peng Liu, Oliver J. Gruss, Anna Böhler, Christian M. T. Spahn, Dirk Flemming, Elmar Schiebel, Till Rudack
Publikováno v:
Nature. 578(7795)
Microtubules are dynamic polymers of α- and β-tubulin and have crucial roles in cell signalling, cell migration, intracellular transport and chromosome segregation1. They assemble de novo from αβ-tubulin dimers in an essential process termed micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941dff3adbc1ed17c7debff47d2b9794
https://pubmed.ncbi.nlm.nih.gov/31856152
https://pubmed.ncbi.nlm.nih.gov/31856152