Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Erik Weis"'
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102467- (2021)
Summary: Late-stage functionalization (LSF) has over the past years emerged as a powerful approach in the drug discovery process. At its best, it allows for rapid access to new analogues from a single drug-like molecule, bypassing the need for de nov
Externí odkaz:
https://doaj.org/article/c92a73b86d4b4f5c91d97ac885ddb370
Publikováno v:
JACS Au. 2:906-916
Herein, we report an iridium-catalyzed directed C-H amination methodology developed using a high-throughput experimentation (HTE)-based strategy, applicable for the needs of automated modern drug discovery. The informer library approach for investiga
Publikováno v:
Chemistry – A European Journal. 27:18188-18200
Functionalization of C-H bonds, ubiquitous in drugs and drug-like molecules, represents an important synthetic strategy with a potential to streamline the drug discovery process. Late-stage aromatic C-N bond forming reactions are highly desirable, bu
Publikováno v:
The Power of High-Throughput Experimentation: Case Studies from Drug Discovery, Drug Development, and Catalyst Discovery (Volume 2) ISBN: 9780841297555
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d30a0b70619e99d9a6b59580cb62d4c4
https://doi.org/10.1021/bk-2022-1420.ch010
https://doi.org/10.1021/bk-2022-1420.ch010
Herein, we report an iridium-catalyzed directed C−H amination methodology developed using a high-throughput experimentation (HTE)-based strategy, applicable for the needs of automated modern drug discovery. The informer library approach for investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ef1c795d86d6bda67b10ed1a900befe
https://doi.org/10.26434/chemrxiv-2021-vp0kl
https://doi.org/10.26434/chemrxiv-2021-vp0kl
Autor:
Erik Weis, Anders Foller Füchtbauer, Pauline Pfeiffer, Mattias Bood, Jesper R. Nilsson, Anders Dahlén, Marcus Wilhelmsson, Moa Sandberg Wranne, Morten Grøtli
Publikováno v:
Nucleic Acids Research
Published by Oxford University Press on behalf of Nucleic Acids Research. Interbase FRET can reveal highly detailed information about distance, orientation and dynamics in nucleic acids, complementing the existing structure and dynamics techniques. W
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
An iridium‐catalyzed selective ortho‐monoiodination of benzoic acids with two equivalent C−H bonds is presented. A wide range of electron‐rich and electron‐poor substrates undergo the reaction under mild conditions, with >20:1 mono/di selec
Autor:
Marion H. Emmert, Matthieu Jouffroy, David C. Leitch, Alexander Buitrago Santanilla, Gemma Cook, Amanda Dombrowski, Nathan Gesmundo, Dipannita Kalyani, Mycah Uehling, Michael Wleklinski, Nicole C. Goodwin, Katherine Honicker, Jonathan Latham, Katherine M. P. Wheelhouse, Sabine Fenner, Matthew P. Whiting, Chunrui Sun, Ji Qi, Feng Peng, Niki R. Patel, Danielle Schultz, Orion Staples, Jacob S. Mohar, Daniel J. Mindiola, Victoria Dimakos, Stephen G. Newman, Stig D. Friis, Erik Weis, Magnus J. Johansson
'High-throughput experimentation (HTE) is an emerging and powerful approach to problems in organic chemistry and homogeneous catalysis. This book is targeted at both experts and those new to the field who are seeking general perspectives and design p
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102467-(2021)
iScience
iScience
Summary Late-stage functionalization (LSF) has over the past years emerged as a powerful approach in the drug discovery process. At its best, it allows for rapid access to new analogues from a single drug-like molecule, bypassing the need for de novo
Autor:
Stanislav Drápela, Karel Souček, Erik Weis, Kamil Paruch, PrashantKumar Khirsariya, Michal Poljak, Santosh Kumar Adla, Ondřej Hylse, Soňa Krajčovičová, Lukáš Maier, Lenka Černová
Publikováno v:
The Journal of Organic Chemistry. 82:3382-3402
Carbocyclic C-nucleosides are quite rare. Our route enables flexible preparation of three classes of these nucleoside analogs from common precursors-properly substituted cyclopentanones, which can be prepared racemic (in six steps) or optically pure