Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Erik Wagner"'
Autor:
Erik Wagner, Wolfram Brenig
We study the spectrum of a bilayer of Kitaev magnets on the honeycomb lattice, coupled by Heisenberg exchange in the quantum-dimer phase at strong interlayer coupling. Using the perturbative Continuous Unitary transformation (pCUT) we perform series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8181240e918cf9cfd3a39d9a82067d0f
http://arxiv.org/abs/2103.13402
http://arxiv.org/abs/2103.13402
Autor:
Elizabeth A. Ottinger, Mark Payne, Amy Wang, Bonnie Rup, Eric Gonzalez, Xin Xu, David Bettoun, Erik Wagner, Nicholas Mess
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a52d7b1c4a5c4fbd20a5c6d28fc92e6
https://doi.org/10.1016/j.dmpk.2020.04.056
https://doi.org/10.1016/j.dmpk.2020.04.056
Autor:
Wolfram Brenig, Darshan G. Joshi, Matthias Vojta, Kai Phillip Schmidt, Urban F. P. Seifert, Erik Wagner, Julian Gritsch
Kitaev's honeycomb-lattice spin-$1/2$ model has become a paradigmatic example for $\mathbb{Z}_2$ quantum spin liquids, both gapped and gapless. Here we study the fate of these spin-liquid phases in differently stacked bilayer versions of the Kitaev m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f4c61d61cf86788a4e1a1c13b9e91b
http://arxiv.org/abs/1806.01852
http://arxiv.org/abs/1806.01852
Autor:
Steve Jacobsen, Peter H. Reinhart, Albert J. Robichaud, William Ronald Solvibile, Michael S. Malamas, Jim Turner, Koi Michele Morris, Andrea Olland, Ping Zhou, Kristi Fan, Jim Erdei, Menelas N. Pangalos, David Riddell, Dominick Anthony Quagliato, Erik Wagner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6597-6605
The identification of small molecule aminohydantoins as potent and selective human β-secretase inhibitors is reported. These analogs exhibit good brain permeability (40-70%), low nanomolar potency for BACE1, and demonstrate >100-fold selectivity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17719aeaede49b88c03aa1d414605290
https://doi.org/10.1016/j.bmcl.2010.09.029
https://doi.org/10.1016/j.bmcl.2010.09.029
Autor:
Erik Wagner, Jonathan A. Bard, Kristine Svenson, Guixan Jin, Rajiv Chopra, Mei-Chu Lo, Minakshi Jani, Eric S. Manas, Pawel Nowak, Derek C. Cole, John W. Ellingboe, Baihua Hu, Robichaud Albert Jean, Kristi Fan, Michael S. Malamas, Rani Narasimhan, Jim Turner, Ann Aulabaugh, Ping Zhou, Rebecca Cowling, Steve Jacobsen, Peter H. Reinhart, Joseph Raymond Stock, Joan Subrath
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:632-635
8,8-Diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine (1) was identified through HTS, as a weak (micromolar) inhibitor of BACE1. X-Ray crystallographic studies indicate the 2-aminoimidazole ring forms key H-bonding interactions with Asp32 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f64763182d742185f38a6b59ffe4de0
https://doi.org/10.1016/j.bmcl.2009.11.052
https://doi.org/10.1016/j.bmcl.2009.11.052
Autor:
Jonathan A. Bard, Michael S. Malamas, Kristi Fan, Andrea Olland, Albert J. Robichaud, Erik Wagner, Yun Hu, Yu Hui, Iwan Gunawan, Jim Turner, Matthew R. Johnson, Jim Erdei, Keith D. Barnes
Publikováno v:
Journal of Medicinal Chemistry. 52:6314-6323
The identification of small molecule aminoimidazoles as potent and selective human beta-secretase inhibitors is reported. These analogues demonstrate low nannomolar potency for BACE1 in a FRET assay, exhibit comparable activity in a cell-based (ELISA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aded807991850e84a3d1ebc0b011df4
https://doi.org/10.1021/jm9006752
https://doi.org/10.1021/jm9006752
Autor:
Erik Wagner, Kevin Atchison, Julius Jefferson, Yolanda Kirksey, J. Steve Jacobsen, Helen K. Warwick, Peter J. Atkinson, Adrienne Parratt, David Riddell, Margaret M. Zaleska, Zhuting Li, Lin Xu, Peter H. Reinhart, Hua Zhou, Menelas N. Pangalos, J. Xu, Suzan Aschmies, Yun Hu
Publikováno v:
The Journal of Neuroscience. 28:11445-11453
Inheritance of the apoE4 allele (epsilon4) increases the risk of developing Alzheimer's disease; however, the mechanisms underlying this association remain elusive. Recent data suggest that inheritance of epsilon4 may lead to reduced apoE protein lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b63cdd1d3624dc219320bd1dd8ccc06
https://doi.org/10.1523/jneurosci.1972-08.2008
https://doi.org/10.1523/jneurosci.1972-08.2008
Autor:
Lee D. Jennings, Derek C. Cole, Joseph R. Stock, Mohani N. Sukhdeo, John W. Ellingboe, Rebecca Cowling, Guixian Jin, Eric S. Manas, Kristi Y. Fan, Michael S. Malamas, Boyd L. Harrison, Steve Jacobsen, Rajiv Chopra, Peter A. Lohse, William J. Moore, Mary-Margaret O’Donnell, Yun Hu, Albert J. Robichaud, M. James Turner, Erik Wagner, Jonathan Bard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:767-771
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fa246612a7bf5b71fce9eca165375d2
https://doi.org/10.1016/j.bmcl.2007.11.043
https://doi.org/10.1016/j.bmcl.2007.11.043
Autor:
Jonathan A. Bard, Michael S. Malamas, E.S. Manas, Guixan Jin, Rebecca Cowling, Albert J. Robichaud, William Ronald Solvibile, Yun Hu, Jim Turner, Erik Wagner, William Floyd Fobare, Rajiv Chopra
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5353-5356
A series of thiophene-substituted acylguanidines were designed from a pyrrole substituted acylguanidine HTS lead. This template allowed a greater flexibility, through differential Suzuki couplings, to explore the binding site of BACE1 and to enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4b3dd8fc11b23029f7bcb83b6b9caa
https://doi.org/10.1016/j.bmcl.2007.08.010
https://doi.org/10.1016/j.bmcl.2007.08.010
Autor:
Richard G. Fessler, Julia S. Kuliwaba, Dong-Kyu Chin, Bing Wang, Choll W. Kim, Andre Van Ooij, Kern Singh, Jason O. Toy, Paul C. Ivancic, Bryan W. Cunningham, Kirkham Wood, Michael P. McClincy, Leonard I. Voronov, Barry W. L. Tan, Jean-Charles Le Huec, Roberto Diaz, Haibo Fan, Gwendolyn A. Sowa, Guoan Li, Peng Huang, Tim Brown, Adam M. Pearson, Rob D. Dickerman, Ilona M. Punt, Erin M. Shucosky, Todd J. Albert, Chan-Shik Shim, Karen M. Shibata, Thierry Dufour, Jean Huppert, Dilip K. Sengupta, Paul C. McAfee, Moe R. Lim, Karin Büttner-Janz, Constantine K. Demetropoulos, Larry T. Khoo, Daniel H. Kim, Naresh Kumar, James F. Zucherman, Hervé Chataigner, Lisa Ferreara, Archibald von Strempel, Kirill F. Ilalov, Faiz U. Ahmad, Nam Vo, Jérôme Allain, Gilles G. DuBois, Darren R. Lebl, Michael Wang, Hee-Kit Wong, Hansen A. Yuan, Erik Wagner, Hee Kit-Wong, Shaobai Wang, Michael B. Mayor, Steven J. Fineberg, Alejandro Marquez-Lara, Christoph R. Schätz, Liana Chotikul, Donna D. Ohnmeiss, Alexander R. Vaccaro, Domagoj Coric, Robert M. Havey, Fred H. Geisler, Adewale O. Adeniran, James D. Kang, Elizabeth Yu, Luiz Pimenta, Sang-Ho Lee, Alex Ha, Avinash G. Patwardhan, Jordan McAfee, Jean-Paul Steib, Alok D. Sharan, Do Heum Yoon, Qi-Bin Bao, Casey K. Lee, Rudolf Bertagnoli, Matthew Oglesby, Huang Peng, Young-Soo Kim, Stephane Aunoble, Abhay Nene, Miguel Pelton, Ali Kiapour, Paul D. Kim, William E. Neway, Marc Ameil, Troy Morrison, William F. Lavelle, Federico P. Girardi, Antonio Faundez, Anand K. Agarwal, Jack E. Zigler, Vikas Kaul, Frank P. Cammisa, Jesse L. Even, Joon Y. Lee, Frank M. Phillips, Sreeharsha V. Nandyala, Brian J. C. Freeman, Scott Webb, Jonathan A. Gimbel, Vijay K. Goel, James Joseph Yue, Uday Pawar, Charles R. Gordon, Carl Lauryssen, Richard D. Guyer, JayDeep Ghosh, Jonathan D. Krystal, Conor Regan, Vivek Palepu, Aakash Agarwal, Matthew N. Songer, Jacques Beaurain, Chadi Tannoury, Joël Delécrin, Ata M. Kiapour
Publikováno v:
Dynamic Reconstruction of the Spine
Book Review by Pierre Kehr • Bone graft substitutes: Mesenchymal stem cells remain an area of interest, though the amount of cells needed to elicit a bonehealing response as well as what triggers need to be expressed by the cells is unknown. • Di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4c7084a3f3e0a53600aa736b60bebef
https://doi.org/10.1055/b-003-108511
https://doi.org/10.1055/b-003-108511